Noninvasive Treatment of Central Post-Stroke Neuropathic Pain

Ya-Wen Tu, Wei-Ting Wu, Chih-Chung Liu, Ya-Chen Lee, Yih-Tsen Lai

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Central post-stroke pain (CPSP) is a neuropathic pain syndrome occurring after a cerebrovascular accident in 8 to 14 % of patients with stroke. This pain is largely refractory to medicinal and surgical treatments. Investigators have assayed numerous types of medicines and therapies for CPSP, but large controlled trials are lacking, and a treatment method is far from being standardized. OBJECTIVE: To review the current pharmacological treatments for CPSP and other noninvasive modality options, and to evaluate the strength of evidence on the efficacies of the treatment forms. METHODS: Search strategies with the keywords ”neuropathic pain,” ”stroke,” and ”central post-stroke pain” were used in combination with ”pharmacological treatment,” ”acupuncture,” ”neurostimulation,” ”physical therapy,” ”modality”and ”transcutaneous electrical nerve stimulation” as treatment options. The retrieved articles relating to CPSP were reviewed. RESULTS: The pathophysiology of CPSP is not well understood, but previous research has suggested central disinhibition, imbalance of stimuli, and central sensitization as underlying mechanisms. Amitriptyline and lamotrigine are recommended as first-line drugs, with mexiletine, fluvoxamine, and gabapentin as second-line drugs. There are numerous non-pharmacological therapies for CPSP, but more extensive research is required to determine their efficacies. CONCLUSIONS: CPSP patients present with diverse sensory symptoms. The pathophysiology of CPSP is still poorly understood; thus, further studies are needed to elucidate the underlying mechanisms and investigate newer therapeutic modalities.
Original languageEnglish
Pages (from-to)67-76
Number of pages10
Journal疼痛醫學雜誌
Volume21
Issue number2
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Neuralgia
Stroke
Pain
Therapeutics
Pharmacology
Acupuncture Therapy
Mexiletine
Central Nervous System Sensitization
Fluvoxamine
Transcutaneous Electric Nerve Stimulation
Amitriptyline
Research
Pharmaceutical Preparations
Research Personnel

Keywords

  • 中樞性神經性疼痛
  • 藥物治療
  • 非侵入性
  • post-stroke pain
  • neuropathic
  • non-invasive treatment

Cite this

Noninvasive Treatment of Central Post-Stroke Neuropathic Pain. / Tu, Ya-Wen; Wu, Wei-Ting; Liu, Chih-Chung; Lee, Ya-Chen; Lai, Yih-Tsen.

In: 疼痛醫學雜誌, Vol. 21, No. 2, 2011, p. 67-76.

Research output: Contribution to journalArticle

Tu, Ya-Wen ; Wu, Wei-Ting ; Liu, Chih-Chung ; Lee, Ya-Chen ; Lai, Yih-Tsen. / Noninvasive Treatment of Central Post-Stroke Neuropathic Pain. In: 疼痛醫學雜誌. 2011 ; Vol. 21, No. 2. pp. 67-76.
@article{22b647089bdb430090a7ef32df5d314d,
title = "Noninvasive Treatment of Central Post-Stroke Neuropathic Pain",
abstract = "BACKGROUND: Central post-stroke pain (CPSP) is a neuropathic pain syndrome occurring after a cerebrovascular accident in 8 to 14 {\%} of patients with stroke. This pain is largely refractory to medicinal and surgical treatments. Investigators have assayed numerous types of medicines and therapies for CPSP, but large controlled trials are lacking, and a treatment method is far from being standardized. OBJECTIVE: To review the current pharmacological treatments for CPSP and other noninvasive modality options, and to evaluate the strength of evidence on the efficacies of the treatment forms. METHODS: Search strategies with the keywords ”neuropathic pain,” ”stroke,” and ”central post-stroke pain” were used in combination with ”pharmacological treatment,” ”acupuncture,” ”neurostimulation,” ”physical therapy,” ”modality”and ”transcutaneous electrical nerve stimulation” as treatment options. The retrieved articles relating to CPSP were reviewed. RESULTS: The pathophysiology of CPSP is not well understood, but previous research has suggested central disinhibition, imbalance of stimuli, and central sensitization as underlying mechanisms. Amitriptyline and lamotrigine are recommended as first-line drugs, with mexiletine, fluvoxamine, and gabapentin as second-line drugs. There are numerous non-pharmacological therapies for CPSP, but more extensive research is required to determine their efficacies. CONCLUSIONS: CPSP patients present with diverse sensory symptoms. The pathophysiology of CPSP is still poorly understood; thus, further studies are needed to elucidate the underlying mechanisms and investigate newer therapeutic modalities.",
keywords = "中樞性神經性疼痛, 藥物治療, 非侵入性, post-stroke pain, neuropathic, non-invasive treatment",
author = "Ya-Wen Tu and Wei-Ting Wu and Chih-Chung Liu and Ya-Chen Lee and Yih-Tsen Lai",
year = "2011",
doi = "10.29792/TTJP.201109.0005",
language = "English",
volume = "21",
pages = "67--76",
journal = "疼痛醫學雜誌",
issn = "1021-7959",
publisher = "臺灣疼痛醫學會",
number = "2",

}

TY - JOUR

T1 - Noninvasive Treatment of Central Post-Stroke Neuropathic Pain

AU - Tu, Ya-Wen

AU - Wu, Wei-Ting

AU - Liu, Chih-Chung

AU - Lee, Ya-Chen

AU - Lai, Yih-Tsen

PY - 2011

Y1 - 2011

N2 - BACKGROUND: Central post-stroke pain (CPSP) is a neuropathic pain syndrome occurring after a cerebrovascular accident in 8 to 14 % of patients with stroke. This pain is largely refractory to medicinal and surgical treatments. Investigators have assayed numerous types of medicines and therapies for CPSP, but large controlled trials are lacking, and a treatment method is far from being standardized. OBJECTIVE: To review the current pharmacological treatments for CPSP and other noninvasive modality options, and to evaluate the strength of evidence on the efficacies of the treatment forms. METHODS: Search strategies with the keywords ”neuropathic pain,” ”stroke,” and ”central post-stroke pain” were used in combination with ”pharmacological treatment,” ”acupuncture,” ”neurostimulation,” ”physical therapy,” ”modality”and ”transcutaneous electrical nerve stimulation” as treatment options. The retrieved articles relating to CPSP were reviewed. RESULTS: The pathophysiology of CPSP is not well understood, but previous research has suggested central disinhibition, imbalance of stimuli, and central sensitization as underlying mechanisms. Amitriptyline and lamotrigine are recommended as first-line drugs, with mexiletine, fluvoxamine, and gabapentin as second-line drugs. There are numerous non-pharmacological therapies for CPSP, but more extensive research is required to determine their efficacies. CONCLUSIONS: CPSP patients present with diverse sensory symptoms. The pathophysiology of CPSP is still poorly understood; thus, further studies are needed to elucidate the underlying mechanisms and investigate newer therapeutic modalities.

AB - BACKGROUND: Central post-stroke pain (CPSP) is a neuropathic pain syndrome occurring after a cerebrovascular accident in 8 to 14 % of patients with stroke. This pain is largely refractory to medicinal and surgical treatments. Investigators have assayed numerous types of medicines and therapies for CPSP, but large controlled trials are lacking, and a treatment method is far from being standardized. OBJECTIVE: To review the current pharmacological treatments for CPSP and other noninvasive modality options, and to evaluate the strength of evidence on the efficacies of the treatment forms. METHODS: Search strategies with the keywords ”neuropathic pain,” ”stroke,” and ”central post-stroke pain” were used in combination with ”pharmacological treatment,” ”acupuncture,” ”neurostimulation,” ”physical therapy,” ”modality”and ”transcutaneous electrical nerve stimulation” as treatment options. The retrieved articles relating to CPSP were reviewed. RESULTS: The pathophysiology of CPSP is not well understood, but previous research has suggested central disinhibition, imbalance of stimuli, and central sensitization as underlying mechanisms. Amitriptyline and lamotrigine are recommended as first-line drugs, with mexiletine, fluvoxamine, and gabapentin as second-line drugs. There are numerous non-pharmacological therapies for CPSP, but more extensive research is required to determine their efficacies. CONCLUSIONS: CPSP patients present with diverse sensory symptoms. The pathophysiology of CPSP is still poorly understood; thus, further studies are needed to elucidate the underlying mechanisms and investigate newer therapeutic modalities.

KW - 中樞性神經性疼痛

KW - 藥物治療

KW - 非侵入性

KW - post-stroke pain

KW - neuropathic

KW - non-invasive treatment

U2 - 10.29792/TTJP.201109.0005

DO - 10.29792/TTJP.201109.0005

M3 - Article

VL - 21

SP - 67

EP - 76

JO - 疼痛醫學雜誌

JF - 疼痛醫學雜誌

SN - 1021-7959

IS - 2

ER -