Noninvasive single-beat determination of left ventricular end-systolic elastance in humans

Chen Huan Chen, Barry Fetics, Erez Nevo, Carlos E. Rochitte, Kuan Rau Chiou, Phillip Yu An Ding, Miho Kawaguchi, David A. Kass

Research output: Contribution to journalArticle

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Abstract

OBJECTIVES: The goal of this study was to develop and validate a method to estimate left ventricular end-systolic elastance (Ees) in humans from noninvasive single-beat parameters. BACKGROUND: Left ventricular end-systolic elastance is a major determinant of cardiac systolic function and ventricular-arterial interaction. However, its use in heart failure assessment and management is limited by lack of a simple means to measure it noninvasively. This study presents a new noninvasive method and validates it against invasively measured Ees. METHODS: Left ventricular end-systolic elastance was calculated by a modified single-beat method employing systolic (Ps) and diastolic (Pd) arm-cuff pressures, echo-Doppler stroke volume (SV), echo-derived ejection fraction and an estimated normalized ventricular elastance at arterial end-diastole (ENd): Ees(sb) = [Pd - (ENd(est) × P5 × 0.9)]/(ENd(est) × SV). The ENd was estimated from a group-averaged value adjusted for individual contractile/loading effects; Ees(sb) estimates were compared with invasively measured values in 43 patients with varying cardiovascular disorders, with additional data recorded after inotropic stimulation (n = 18, dobutamine 5 to 10 μg/kg per min). Investigators performing noninvasive analysis were blinded to the invasive results. RESULTS: Combined baseline and dobutamine-stimulated Ees ranged 0.4 to 8.4 mm Hg/ml and was well predicted by Ees(sb) over the full range: Ees = 0.86 × Ees(sb) + 0.40 (r = 0.91, SEE = 0.64, p < 0.00001, n = 72). Absolute change in Ees(sb) before and after dobutamine also correlated well with invasive measures: Ees(sb): ΔEes = 0.86 × ΔEes(sb) + 0.67 (r = 0.88, p < 0.00001). Repeated measures of Ees(sb) over two months in a separate group of patients (n = 7) yielded a coefficient of variation of 20.3 ± 6%. CONCLUSIONS: The Ees can be reliably estimated from simple noninvasive measurements. This approach should broaden the clinical applicability of this useful parameter for assessing systolic function, therapeutic response and ventricular-arterial interaction.

Original languageEnglish
Pages (from-to)2028-2034
Number of pages7
JournalJournal of the American College of Cardiology
Volume38
Issue number7
DOIs
Publication statusPublished - Dec 17 2001
Externally publishedYes

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Dobutamine
Stroke Volume
Diastole
Ventricular Function
Heart Failure
Research Personnel
Pressure
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Noninvasive single-beat determination of left ventricular end-systolic elastance in humans. / Chen, Chen Huan; Fetics, Barry; Nevo, Erez; Rochitte, Carlos E.; Chiou, Kuan Rau; Ding, Phillip Yu An; Kawaguchi, Miho; Kass, David A.

In: Journal of the American College of Cardiology, Vol. 38, No. 7, 17.12.2001, p. 2028-2034.

Research output: Contribution to journalArticle

Chen, Chen Huan ; Fetics, Barry ; Nevo, Erez ; Rochitte, Carlos E. ; Chiou, Kuan Rau ; Ding, Phillip Yu An ; Kawaguchi, Miho ; Kass, David A. / Noninvasive single-beat determination of left ventricular end-systolic elastance in humans. In: Journal of the American College of Cardiology. 2001 ; Vol. 38, No. 7. pp. 2028-2034.
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AU - Chen, Chen Huan

AU - Fetics, Barry

AU - Nevo, Erez

AU - Rochitte, Carlos E.

AU - Chiou, Kuan Rau

AU - Ding, Phillip Yu An

AU - Kawaguchi, Miho

AU - Kass, David A.

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N2 - OBJECTIVES: The goal of this study was to develop and validate a method to estimate left ventricular end-systolic elastance (Ees) in humans from noninvasive single-beat parameters. BACKGROUND: Left ventricular end-systolic elastance is a major determinant of cardiac systolic function and ventricular-arterial interaction. However, its use in heart failure assessment and management is limited by lack of a simple means to measure it noninvasively. This study presents a new noninvasive method and validates it against invasively measured Ees. METHODS: Left ventricular end-systolic elastance was calculated by a modified single-beat method employing systolic (Ps) and diastolic (Pd) arm-cuff pressures, echo-Doppler stroke volume (SV), echo-derived ejection fraction and an estimated normalized ventricular elastance at arterial end-diastole (ENd): Ees(sb) = [Pd - (ENd(est) × P5 × 0.9)]/(ENd(est) × SV). The ENd was estimated from a group-averaged value adjusted for individual contractile/loading effects; Ees(sb) estimates were compared with invasively measured values in 43 patients with varying cardiovascular disorders, with additional data recorded after inotropic stimulation (n = 18, dobutamine 5 to 10 μg/kg per min). Investigators performing noninvasive analysis were blinded to the invasive results. RESULTS: Combined baseline and dobutamine-stimulated Ees ranged 0.4 to 8.4 mm Hg/ml and was well predicted by Ees(sb) over the full range: Ees = 0.86 × Ees(sb) + 0.40 (r = 0.91, SEE = 0.64, p < 0.00001, n = 72). Absolute change in Ees(sb) before and after dobutamine also correlated well with invasive measures: Ees(sb): ΔEes = 0.86 × ΔEes(sb) + 0.67 (r = 0.88, p < 0.00001). Repeated measures of Ees(sb) over two months in a separate group of patients (n = 7) yielded a coefficient of variation of 20.3 ± 6%. CONCLUSIONS: The Ees can be reliably estimated from simple noninvasive measurements. This approach should broaden the clinical applicability of this useful parameter for assessing systolic function, therapeutic response and ventricular-arterial interaction.

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