Noninvasive imaging of reporter gene expression and distribution in vivo

Kuo Hsiang Chuang, Tian L. Cheng

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Repeated noninvasive imaging of reporter gene expression is increasingly used for monitoring the expression and location of genes and cells in experimental animals and humans. Development of transgenic animals that express reporter genes in specific tissues/organs or the whole body possess the potential for understanding the course of disease or serve as a syngenic cell/tissue/organ donor to study transplant survival in recipients. In this review, we discuss the major reporter genes used in gene therapy, cell therapy and transgenic animals, including exogenous reporters (herpes simplex virus type 1 thymidine kinase, fluorescent proteins and luciferase) and endogenous reporters (dopamine 2 receptor, transferrin receptor, sodium iodide symporter, β-glucuronidase, and antibody reporter). The clinical potential of these reporter genes is also discussed with regard to their imaging specificity and immunogenicity in humans.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalFooyin Journal of Health Sciences
Volume2
Issue number1
DOIs
Publication statusPublished - Feb 2010
Externally publishedYes

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Keywords

  • Endogenous reporter
  • Exogenous reporter
  • Noninvasive imaging
  • Reporter gene

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biomedical Engineering
  • Medicine(all)
  • Drug Discovery

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