Nonhistone proteins HMG1 and HMG2 change the DNA helical structure

Kashayar Javaherian, Leroy-Fong Liu, James C. Wang

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG1 and HMG2, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.

Original languageEnglish
Pages (from-to)1345-1346
Number of pages2
JournalScience
Volume199
Issue number4335
Publication statusPublished - 1978
Externally publishedYes

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HMGB2 Protein
HMGB1 Protein
Circular DNA
DNA
Thymus Gland
Chromatin
Proteins

ASJC Scopus subject areas

  • General

Cite this

Javaherian, K., Liu, L-F., & Wang, J. C. (1978). Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. Science, 199(4335), 1345-1346.

Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. / Javaherian, Kashayar; Liu, Leroy-Fong; Wang, James C.

In: Science, Vol. 199, No. 4335, 1978, p. 1345-1346.

Research output: Contribution to journalArticle

Javaherian, K, Liu, L-F & Wang, JC 1978, 'Nonhistone proteins HMG1 and HMG2 change the DNA helical structure', Science, vol. 199, no. 4335, pp. 1345-1346.
Javaherian, Kashayar ; Liu, Leroy-Fong ; Wang, James C. / Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. In: Science. 1978 ; Vol. 199, No. 4335. pp. 1345-1346.
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