Non-Watson-Crick G. C and A. T Base Pairs in a DNA-antibiotic complex

Gary J. Quigley, Giovanni Ughetto, Gijs A. Van Der Marel, Jacques H. Van Boom, Andrew H.J. Wang, Alexander Rich

Research output: Contribution to journalArticlepeer-review

123 Citations (Scopus)

Abstract

The structure of a DNA octamer d(GCGTACGC) cocrystallized with the bisintercalator antibiotic triostin A has been solved. The DNA forms an unwound right-handed double helix. Four base pairs are of the Watson-Crick type while four are Hoogsteen base pairs, including two A · T and two G · C base pairs. This is the first observation in an oligonucleotide of Hoogsteen G · C base pairs where the cystosine is protonated. It is likely that these also occur in solutions of DNA complexed to this antibiotic.

Original languageEnglish
Pages (from-to)1255-1258
Number of pages4
JournalScience
Volume232
Issue number4755
DOIs
Publication statusPublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • General

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