Non-surgical periodontal therapy with and without subgingival minocycline administration in patients with poorly controlled type II diabetes: A randomized controlled clinical trial

Shih Jung Lin, Yu Kang Tu, Shiow Chwen Tsai, Shih Ming Lai, Hsein Kun Lu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The aim of this study was to evaluate changes in clinical parameters and levels of inflammatory biomarkers in plasma in periodontal patients with poorly controlled type 2 diabetes mellitus (T2DM) after non-surgical periodontal therapy. Twenty-eight poorly controlled T2DM patients were randomly assigned to treatment with scaling and root planning (SRP) and SRP + subgingival minocycline administration. Clinical parameters, including the probing depth (PD), bleeding on probing (BOP), plaque score (PS), clinical attachment level (CAL), and plasma interleukin (IL)-6, soluble receptor of advanced glycation end products (sRAGE), chronic reactive protein (CRP), and hemoglobin A1c (HbA1c) were measured before and after a 6-month treatment period. Significant changes in PD, BOP, PS, and CAL were found in both groups. The latent growth curve model showed an overall reduction in the log HbA1c level in the SRP group (-0. 082, p = 0. 033). Small changes in the log sRAGE level and log CRP level in plasma were found in both groups. IL-6 in the plasma increased in the SRP group, but slightly decreased in the SRP+minocycline group (0. 469 pg/ml, p = 0. 172). Non-surgical periodontal therapy with or without subgingival minocycline application may achieve significant periodontal improvement and moderate improvement in HbA1c, but had no significant effect on plasma levels of IL-6, CRP, or sRAGE in patients with poorly controlled T2DM. For patients with both periodontal diseases and diabetes, non-surgical periodontal treatments may be helpful in their diabetic control.

Original languageEnglish
Pages (from-to)599-609
Number of pages11
JournalClinical Oral Investigations
Volume16
Issue number2
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Dental Scaling
Minocycline
Type 2 Diabetes Mellitus
Randomized Controlled Trials
Hemoglobins
Interleukin-6
Hemorrhage
Therapeutics
Interleukin-6 Receptors
Proteins
Periodontal Diseases
Biomarkers
Growth
Advanced Glycosylation End Product-Specific Receptor

Keywords

  • CRP
  • HbA1c
  • Minocycline
  • Root planning
  • sRAGE
  • Type II diabetes

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Non-surgical periodontal therapy with and without subgingival minocycline administration in patients with poorly controlled type II diabetes : A randomized controlled clinical trial. / Lin, Shih Jung; Tu, Yu Kang; Tsai, Shiow Chwen; Lai, Shih Ming; Lu, Hsein Kun.

In: Clinical Oral Investigations, Vol. 16, No. 2, 04.2012, p. 599-609.

Research output: Contribution to journalArticle

@article{e6aa18b8c53c49eba3790809776e30f4,
title = "Non-surgical periodontal therapy with and without subgingival minocycline administration in patients with poorly controlled type II diabetes: A randomized controlled clinical trial",
abstract = "The aim of this study was to evaluate changes in clinical parameters and levels of inflammatory biomarkers in plasma in periodontal patients with poorly controlled type 2 diabetes mellitus (T2DM) after non-surgical periodontal therapy. Twenty-eight poorly controlled T2DM patients were randomly assigned to treatment with scaling and root planning (SRP) and SRP + subgingival minocycline administration. Clinical parameters, including the probing depth (PD), bleeding on probing (BOP), plaque score (PS), clinical attachment level (CAL), and plasma interleukin (IL)-6, soluble receptor of advanced glycation end products (sRAGE), chronic reactive protein (CRP), and hemoglobin A1c (HbA1c) were measured before and after a 6-month treatment period. Significant changes in PD, BOP, PS, and CAL were found in both groups. The latent growth curve model showed an overall reduction in the log HbA1c level in the SRP group (-0. 082, p = 0. 033). Small changes in the log sRAGE level and log CRP level in plasma were found in both groups. IL-6 in the plasma increased in the SRP group, but slightly decreased in the SRP+minocycline group (0. 469 pg/ml, p = 0. 172). Non-surgical periodontal therapy with or without subgingival minocycline application may achieve significant periodontal improvement and moderate improvement in HbA1c, but had no significant effect on plasma levels of IL-6, CRP, or sRAGE in patients with poorly controlled T2DM. For patients with both periodontal diseases and diabetes, non-surgical periodontal treatments may be helpful in their diabetic control.",
keywords = "CRP, HbA1c, Minocycline, Root planning, sRAGE, Type II diabetes",
author = "Lin, {Shih Jung} and Tu, {Yu Kang} and Tsai, {Shiow Chwen} and Lai, {Shih Ming} and Lu, {Hsein Kun}",
year = "2012",
month = "4",
doi = "10.1007/s00784-011-0535-x",
language = "English",
volume = "16",
pages = "599--609",
journal = "Clinical Oral Investigations",
issn = "1432-6981",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Non-surgical periodontal therapy with and without subgingival minocycline administration in patients with poorly controlled type II diabetes

T2 - A randomized controlled clinical trial

AU - Lin, Shih Jung

AU - Tu, Yu Kang

AU - Tsai, Shiow Chwen

AU - Lai, Shih Ming

AU - Lu, Hsein Kun

PY - 2012/4

Y1 - 2012/4

N2 - The aim of this study was to evaluate changes in clinical parameters and levels of inflammatory biomarkers in plasma in periodontal patients with poorly controlled type 2 diabetes mellitus (T2DM) after non-surgical periodontal therapy. Twenty-eight poorly controlled T2DM patients were randomly assigned to treatment with scaling and root planning (SRP) and SRP + subgingival minocycline administration. Clinical parameters, including the probing depth (PD), bleeding on probing (BOP), plaque score (PS), clinical attachment level (CAL), and plasma interleukin (IL)-6, soluble receptor of advanced glycation end products (sRAGE), chronic reactive protein (CRP), and hemoglobin A1c (HbA1c) were measured before and after a 6-month treatment period. Significant changes in PD, BOP, PS, and CAL were found in both groups. The latent growth curve model showed an overall reduction in the log HbA1c level in the SRP group (-0. 082, p = 0. 033). Small changes in the log sRAGE level and log CRP level in plasma were found in both groups. IL-6 in the plasma increased in the SRP group, but slightly decreased in the SRP+minocycline group (0. 469 pg/ml, p = 0. 172). Non-surgical periodontal therapy with or without subgingival minocycline application may achieve significant periodontal improvement and moderate improvement in HbA1c, but had no significant effect on plasma levels of IL-6, CRP, or sRAGE in patients with poorly controlled T2DM. For patients with both periodontal diseases and diabetes, non-surgical periodontal treatments may be helpful in their diabetic control.

AB - The aim of this study was to evaluate changes in clinical parameters and levels of inflammatory biomarkers in plasma in periodontal patients with poorly controlled type 2 diabetes mellitus (T2DM) after non-surgical periodontal therapy. Twenty-eight poorly controlled T2DM patients were randomly assigned to treatment with scaling and root planning (SRP) and SRP + subgingival minocycline administration. Clinical parameters, including the probing depth (PD), bleeding on probing (BOP), plaque score (PS), clinical attachment level (CAL), and plasma interleukin (IL)-6, soluble receptor of advanced glycation end products (sRAGE), chronic reactive protein (CRP), and hemoglobin A1c (HbA1c) were measured before and after a 6-month treatment period. Significant changes in PD, BOP, PS, and CAL were found in both groups. The latent growth curve model showed an overall reduction in the log HbA1c level in the SRP group (-0. 082, p = 0. 033). Small changes in the log sRAGE level and log CRP level in plasma were found in both groups. IL-6 in the plasma increased in the SRP group, but slightly decreased in the SRP+minocycline group (0. 469 pg/ml, p = 0. 172). Non-surgical periodontal therapy with or without subgingival minocycline application may achieve significant periodontal improvement and moderate improvement in HbA1c, but had no significant effect on plasma levels of IL-6, CRP, or sRAGE in patients with poorly controlled T2DM. For patients with both periodontal diseases and diabetes, non-surgical periodontal treatments may be helpful in their diabetic control.

KW - CRP

KW - HbA1c

KW - Minocycline

KW - Root planning

KW - sRAGE

KW - Type II diabetes

UR - http://www.scopus.com/inward/record.url?scp=84858796365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858796365&partnerID=8YFLogxK

U2 - 10.1007/s00784-011-0535-x

DO - 10.1007/s00784-011-0535-x

M3 - Article

C2 - 21416238

AN - SCOPUS:84858796365

VL - 16

SP - 599

EP - 609

JO - Clinical Oral Investigations

JF - Clinical Oral Investigations

SN - 1432-6981

IS - 2

ER -