Non-muscular invasive bladder cancer: Re-envisioning therapeutic journey from traditional to regenerative interventions

Kuan Wei Shih, Wei Chieh Chen, Ching Hsin Chang, Ting En Tai, Jeng Cheng Wu, Andy C. Huang, Ming Che Liu

Research output: Contribution to journalReview articlepeer-review

Abstract

Non-muscular invasive bladder cancer (NMIBC) is one of the most common cancer and major cause of economical and health burden in developed countries. Progression of NMIBC has been characterized as low-grade (Ta) and high grade (carcinoma in situ and T1). The current surgical intervention for NMIBC includes transurethral resection of bladder tumor; however, its recurrence still remains a challenge. The BCG-based immunotherapy is much effective against low-grade NMIBC. BCG increases the influx of T cells at bladder cancer site and inhibits proliferation of bladder cancer cells. The chemotherapy is another traditional approach to address NMIBC by supplementing BCG. Notwithstanding, these current therapeutic measures possess limited efficacy in controlling NMIBC, and do not provide comprehensive long-term relief. Hence, biomaterials and scaffolds seem an effective medium to deliver therapeutic agents for restructuring bladder post-treatment. The regenerative therapies such as stem cells and PRP have also been explored for possible solution to NMIBC. Based on above-mentioned approaches, we have comprehensively analyzed therapeutic journey from traditional to regenerative interventions for the treatment of NMIBC.

Original languageEnglish
Pages (from-to)868-885
Number of pages18
JournalAging and Disease
Volume12
Issue number3
DOIs
Publication statusPublished - Jun 1 2021

Keywords

  • BCG
  • Bladder cancer
  • NMIBC
  • PRP
  • Stem cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cell Biology

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