Non-alcoholic cirrhosis and the risk of stroke

A 5-year follow-up study

Yi-Hua Chen, Kuan Yang Chen, Herng Ching Lin

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background/Aims: As habitual heavy alcohol consumption is one of the major causes of cirrhosis in the western world, the majority of studies on the relationship between cirrhosis and stroke have focused on patients with alcohol-related liver diseases. Using a nationwide population-based dataset, this study therefore aimed to examine the risk of stroke among non-alcoholic cirrhosis patients over a 5-year period following their diagnosis with non-alcoholic cirrhosis, as compared with the general population during the same period. Methods: We used the 'Longitudinal Health Insurance Database', derived from the Taiwan National Health Insurance program. The study cohort comprised 2336 patients with cirrhosis and the comparison cohort consisted of 11680 randomly selected subjects. Stratified Cox's proportional hazard regressions were performed to compare the 5-year stroke survival rate for the two cohorts. Results: In the total sample of 14016 patients, 1187 patients (8.5%) experienced stroke during the 5-year follow-up period: 176 from the study cohort (7.5% of the patients with cirrhosis) and 1011 from the comparison cohort (8.7% of patients without cirrhosis) (P=0.076). After adjusting for the patients' geographical location, hypertension, diabetes, coronary heart disease, heart failure, atrial fibrillation and hyperlipidaemia, the regression analysis shows that patients with cirrhosis were less likely to experience stroke compared with those without cirrhosis during the 5-year period (hazard ratio=0.59, 95% confidence interval=0.52-0.67, P

Original languageEnglish
Pages (from-to)354-360
Number of pages7
JournalLiver International
Volume31
Issue number3
DOIs
Publication statusPublished - Mar 2011

Fingerprint

Fibrosis
Stroke
National Health Programs
Cohort Studies
Western World
Health Insurance
Hyperlipidemias
Taiwan
Alcohol Drinking
Atrial Fibrillation
Population
Coronary Disease
Liver Diseases
Survival Rate
Heart Failure
Regression Analysis
Alcohols
Databases
Confidence Intervals
Hypertension

Keywords

  • Cirrhosis
  • Non-alcoholic cirrhosis
  • Stroke

ASJC Scopus subject areas

  • Hepatology

Cite this

Non-alcoholic cirrhosis and the risk of stroke : A 5-year follow-up study. / Chen, Yi-Hua; Chen, Kuan Yang; Lin, Herng Ching.

In: Liver International, Vol. 31, No. 3, 03.2011, p. 354-360.

Research output: Contribution to journalArticle

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