Nociceptin-like immunoreactivity in autonomic nuclei of the rat spinal cord

N. J. Dun, S. L. Dun, L. L. Hwang

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


Immunohistochemical techniques were used to localize nociceptin-like immunoreactivity (NOCI-LI) in the rat spinal cords. NOCI-LI nerve fibers were distributed in three fairly well-defined regions: superficial layers of the dorsal horn, central canal area, and intermediolateral cell column (IL(p)) of lower cervical, thoracic, upper lumbar, and sacral segments of the spinal cord. A few NOCI-LI somata of small diameter were noted in the dorsal horn; NOCI-LI cell bodies were infrequently observed in the IL(p) or ventral horn. Concentration of NOCI-LI in nerve fibers of the superficial layers and in fibers projecting into the spinal sympathetic and parasympathetic nuclei suggests that the peptide may participate in sensory as well as autonomic functions.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalNeuroscience Letters
Issue number2-3
Publication statusPublished - Oct 3 1997
Externally publishedYes


  • Dorsal horn
  • Intermediolateral nucleus
  • Nociceptin
  • Opioid peptides
  • Orphanin FQ
  • Spinal autonomic nuclei

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Nociceptin-like immunoreactivity in autonomic nuclei of the rat spinal cord'. Together they form a unique fingerprint.

Cite this