No mutation of G209A in the alpha-synuclein gene in sporadic Parkinson's disease among Taiwan Chinese

Chaur Jong Hu, Shing Ming Sung, Hsing Cheng Liu, Jan Gowth Chang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The role of genetics in Parkinson's disease (PD), previously controversial, is now supported by several studies. A major breakthrough has been the discovery of a single gene defect in familial Parkinson's disease. A single base pair change at position 209 from G to A (G209A) in the fourth exon of the α-synuclein gene has been identified in cases of familial PD. We looked for this mutation in 65 cases of sporadic PD in Taiwan Chinese patients but found none of these patients with this mutation. We conclude that mutation of G209A in the α-synuclein gene plays no role in sporadic PD among Taiwan Chinese.

Original languageEnglish
Pages (from-to)85-87
Number of pages3
JournalEuropean Neurology
Volume41
Issue number2
DOIs
Publication statusPublished - Feb 1999
Externally publishedYes

Fingerprint

alpha-Synuclein
Taiwan
Parkinson Disease
Mutation
Synucleins
Genes
Inborn Genetic Diseases
Base Pairing
Exons

Keywords

  • α-synuclein
  • Chinese
  • Parkinson's disease
  • Taiwan

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

No mutation of G209A in the alpha-synuclein gene in sporadic Parkinson's disease among Taiwan Chinese. / Hu, Chaur Jong; Sung, Shing Ming; Liu, Hsing Cheng; Chang, Jan Gowth.

In: European Neurology, Vol. 41, No. 2, 02.1999, p. 85-87.

Research output: Contribution to journalArticle

Hu, Chaur Jong ; Sung, Shing Ming ; Liu, Hsing Cheng ; Chang, Jan Gowth. / No mutation of G209A in the alpha-synuclein gene in sporadic Parkinson's disease among Taiwan Chinese. In: European Neurology. 1999 ; Vol. 41, No. 2. pp. 85-87.
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