No increased risk of adverse pregnancy outcomes for women with myasthenia gravis: A nationwide population-based study

J. C. Wen, T. C. Liu, Y. H. Chen, S. F. Chen, H. C. Lin, W. C. Tsai

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: This study aims to examine the risk of adverse pregnancy outcomes [low birthweight (LBW), preterm birth, cesarean sections (CS) and babies born small for gestational age (SGA)] in pregnant women with myasthenia gravis (MG), using a 3-year population-based database, taking characteristics of infant and mother into consideration. Methods: This study used two nationwide population-based datasets: the Taiwan National Health Insurance Research Dataset and the Taiwan birth certificate registry. We identified 163 pregnant women with MG during 2001-2003 as the study cohort and 815 randomly selected pregnant women as a comparison cohort. Conditional logistic regression analyses were performed. Results: The results showed that, although these patterns did not reach a statistically significant level, mothers with MG had higher percentages of LBW (6.8%, vs. 5.6%), SGA (17.8%, vs. 14.1%) and cesarean deliveries (44.8%, vs. 37.4%), except for preterm births (8.1%, vs. 8.1%). After adjusting for highest maternal education level, marital status, family monthly income and infant gender and parity, the odds ratios (OR) of LBW, preterm birth, SGA infants, and cesarean delivery for mothers with MG were 1.19 (95% CI = 0.60-2.38), 1.00 (95% CI = 0.54-1.87), 1.30 (95% CI = 0.83-2.04), and 1.33 (95% CI = 0.94-1.88), respectively, as compared to unaffected mothers. Conclusions: We conclude that there were no statistically significant differences in the risk of having preterm, LBW, SGA infants and cesarean deliveries between women with and without MG.

Original languageEnglish
Pages (from-to)889-894
Number of pages6
JournalEuropean Journal of Neurology
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 2009

Fingerprint

Myasthenia Gravis
Pregnancy Outcome
Mothers
Premature Birth
Small for Gestational Age Infant
Pregnant Women
Population
Taiwan
Gestational Age
Birth Certificates
Marital Status
National Health Programs
Parity
Cesarean Section
Registries
Cohort Studies
Logistic Models
Odds Ratio
Regression Analysis
Databases

Keywords

  • Adverse pregnancy outcome
  • Low birthweight
  • Myasthenia gravis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

No increased risk of adverse pregnancy outcomes for women with myasthenia gravis : A nationwide population-based study. / Wen, J. C.; Liu, T. C.; Chen, Y. H.; Chen, S. F.; Lin, H. C.; Tsai, W. C.

In: European Journal of Neurology, Vol. 16, No. 8, 08.2009, p. 889-894.

Research output: Contribution to journalArticle

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abstract = "Background: This study aims to examine the risk of adverse pregnancy outcomes [low birthweight (LBW), preterm birth, cesarean sections (CS) and babies born small for gestational age (SGA)] in pregnant women with myasthenia gravis (MG), using a 3-year population-based database, taking characteristics of infant and mother into consideration. Methods: This study used two nationwide population-based datasets: the Taiwan National Health Insurance Research Dataset and the Taiwan birth certificate registry. We identified 163 pregnant women with MG during 2001-2003 as the study cohort and 815 randomly selected pregnant women as a comparison cohort. Conditional logistic regression analyses were performed. Results: The results showed that, although these patterns did not reach a statistically significant level, mothers with MG had higher percentages of LBW (6.8{\%}, vs. 5.6{\%}), SGA (17.8{\%}, vs. 14.1{\%}) and cesarean deliveries (44.8{\%}, vs. 37.4{\%}), except for preterm births (8.1{\%}, vs. 8.1{\%}). After adjusting for highest maternal education level, marital status, family monthly income and infant gender and parity, the odds ratios (OR) of LBW, preterm birth, SGA infants, and cesarean delivery for mothers with MG were 1.19 (95{\%} CI = 0.60-2.38), 1.00 (95{\%} CI = 0.54-1.87), 1.30 (95{\%} CI = 0.83-2.04), and 1.33 (95{\%} CI = 0.94-1.88), respectively, as compared to unaffected mothers. Conclusions: We conclude that there were no statistically significant differences in the risk of having preterm, LBW, SGA infants and cesarean deliveries between women with and without MG.",
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