Abstract

The objectives of this study were (1) to investigate the incidence of adverse pregnancy outcomes among the epileptic and general populations, including small for gestational age (SGA), low birth weight (LBW) and preterm delivery, using two large-scale nationwide population-based databases, and (2) to compare the risk of these adverse pregnancy outcomes between epileptic women who did and who did not receive antiepileptic drug (AED) treatment during pregnancy. This study used two national datasets: the National Health Insurance Research Dataset and birth certificate registry. We identified a total of 1,182 women who gave birth from 2001 to 2003 in Taiwan who had been diagnosed with epilepsy within the 2 years preceding the index delivery, together with 5,910 matched women as a comparison cohort. Multivariate logistic regression analyses were performed for estimation of risk. We found that approximately 14% of women with epilepsy received AED treatment during gestation. The adjusted odds of LBW, preterm births and SGA for epileptic women not receiving AED treatment during pregnancy were 1.31 (95% CI, 1.02-1.68), 1.35 (95% CI, 1.07-1.71) and 1.23 (95% CI, 1.03-1.46) times that of women without epilepsy, respectively. In contrast, no significant difference in the risk of LBW infants, preterm births and SGA babies was observed between epileptic mothers receiving AED treatment during pregnancy and women without epilepsy. Our study documents an increased risk of adverse pregnancy outcomes for epileptic women who do not receive AED treatment during pregnancy, but none for epileptic women who do receive treatment.

Original languageEnglish
Pages (from-to)1742-1749
Number of pages8
JournalJournal of Neurology
Volume256
Issue number10
DOIs
Publication statusPublished - Oct 2009

Fingerprint

Pregnancy Outcome
Anticonvulsants
Epilepsy
Low Birth Weight Infant
Pregnancy
Gestational Age
Premature Birth
Therapeutics
Birth Certificates
National Health Programs
Taiwan
Population
Registries
Logistic Models
Regression Analysis
Mothers
Parturition
Databases
Incidence
Research

Keywords

  • Epilepsy
  • Pregnancy outcome
  • Preterm birth

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

No increase in adverse pregnancy outcomes for women receiving antiepileptic drugs. / Lin, Hsiu Li; Chen, Yi Hua; Lin, Hsiu Chen; Lin, Herng Ching.

In: Journal of Neurology, Vol. 256, No. 10, 10.2009, p. 1742-1749.

Research output: Contribution to journalArticle

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