No evidence for linkage of long QT syndrome and chromosome 11p15.5 markers in a Chinese family

evidence for genetic heterogeneity

Yu Lin Ko, Shih Ann Chen, Tang K. Tang, Jiunn Lee Lin, Chern En Chiang, Jin Jer Chen, Ming Sheng Teng, Mau Song Chang, Wen Pin Lien, Cheng Wen Wu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Recently the defective gene locus in seven Caucasian families with the Romano-Ward form of long QT syndrome (LQT) has been mapped to chromosome 11p. To understand the molecular basis of LQT in Chinese, a three-generation family was investigated. Fourteen family members were studied and five individuals were diagnosed to be affected, according to electrocardiographic criteria. Two genomic DNA probes (c-Ha-ras-3′-HVR and insulin-5′-HVR) and one tetranucleotide repeat polymorphism (THZ) derived from chromosome 11p15.5 loci and previously demonstrated to be closely linked to LQT were used as probes to analyze this family. A lod score of less than -2 was noted for all three polymorphisms. Our data show that there was no evidence of linkage between these three loci and the gene for LQT in this studied family. We believe that this result provides additional evidence for genetic heterogeneity of LQT.

Original languageEnglish
Pages (from-to)364-366
Number of pages3
JournalHuman Genetics
Volume94
Issue number4
DOIs
Publication statusPublished - Oct 1 1994
Externally publishedYes

Fingerprint

Long QT Syndrome
Genetic Heterogeneity
Genetic Markers
Chromosomes
Lod Score
DNA Probes
Microsatellite Repeats
Genes
Insulin

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

No evidence for linkage of long QT syndrome and chromosome 11p15.5 markers in a Chinese family : evidence for genetic heterogeneity. / Ko, Yu Lin; Chen, Shih Ann; Tang, Tang K.; Lin, Jiunn Lee; Chiang, Chern En; Chen, Jin Jer; Teng, Ming Sheng; Chang, Mau Song; Lien, Wen Pin; Wu, Cheng Wen.

In: Human Genetics, Vol. 94, No. 4, 01.10.1994, p. 364-366.

Research output: Contribution to journalArticle

Ko, YL, Chen, SA, Tang, TK, Lin, JL, Chiang, CE, Chen, JJ, Teng, MS, Chang, MS, Lien, WP & Wu, CW 1994, 'No evidence for linkage of long QT syndrome and chromosome 11p15.5 markers in a Chinese family: evidence for genetic heterogeneity', Human Genetics, vol. 94, no. 4, pp. 364-366. https://doi.org/10.1007/BF00201594
Ko, Yu Lin ; Chen, Shih Ann ; Tang, Tang K. ; Lin, Jiunn Lee ; Chiang, Chern En ; Chen, Jin Jer ; Teng, Ming Sheng ; Chang, Mau Song ; Lien, Wen Pin ; Wu, Cheng Wen. / No evidence for linkage of long QT syndrome and chromosome 11p15.5 markers in a Chinese family : evidence for genetic heterogeneity. In: Human Genetics. 1994 ; Vol. 94, No. 4. pp. 364-366.
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