No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis

Y. T. Chang, W. R. Lee, C. W. Yu, H. N. Liu, M. W. Lin, C. H. Huang, C. C. Chen, D. D. Lee, W. J. Wang, Jun-Hung Hu, S. F. Tsai

Research output: Contribution to journalArticle

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Abstract

Background. Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, the IL-4 receptor, IL-13, and signal transducer and activator 6 (STAT6) may contribute to susceptibility of AD. To date, no cytokine gene polymorphism study has been conducted on Chinese patients with AD. Aims. To determine whether genetic polymorphisms of the cytokine genes might influence the development of AD. Methods. DNA samples were obtained from 94 patients and 186 control subjects. Using direct sequencing and microsatellite genotyping, we examined 22 polymorphisms in eight cytokine genes including the genes for IL-4, -10, -12B and -13, the IL-4 receptor, tumour necrosis factor (TNF)-α, STAT6, and interferon (IFN)-γ. Results. No significantly different allelic and genotypic distributions of the cytokine gene polymorphisms could be found between patients and controls. Moreover, no association was observed with disease onset, gender, the presence of elevated serum total IgE level or blood eosinophilia. Conclusion. Our study suggests that the analysed genetic polymorphisms of cytokine genes do not appear to be associated with AD susceptibility in our Chinese population.

Original languageEnglish
Pages (from-to)419-423
Number of pages5
JournalClinical and Experimental Dermatology
Volume31
Issue number3
DOIs
Publication statusPublished - May 2006

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Atopic Dermatitis
Cytokines
Genes
Genetic Polymorphisms
Transducers
Interleukin-4
Type II Interleukin-4 Receptors
Interleukin-4 Receptors
Th2 Cells
Interleukin-13
Eosinophilia
Skin Diseases
Interleukin-10
Microsatellite Repeats
Interferons
Immunoglobulin E
Tumor Necrosis Factor-alpha
DNA
Serum
Population

ASJC Scopus subject areas

  • Dermatology

Cite this

No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis. / Chang, Y. T.; Lee, W. R.; Yu, C. W.; Liu, H. N.; Lin, M. W.; Huang, C. H.; Chen, C. C.; Lee, D. D.; Wang, W. J.; Hu, Jun-Hung; Tsai, S. F.

In: Clinical and Experimental Dermatology, Vol. 31, No. 3, 05.2006, p. 419-423.

Research output: Contribution to journalArticle

Chang, YT, Lee, WR, Yu, CW, Liu, HN, Lin, MW, Huang, CH, Chen, CC, Lee, DD, Wang, WJ, Hu, J-H & Tsai, SF 2006, 'No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis', Clinical and Experimental Dermatology, vol. 31, no. 3, pp. 419-423. https://doi.org/10.1111/j.1365-2230.2006.02124.x
Chang, Y. T. ; Lee, W. R. ; Yu, C. W. ; Liu, H. N. ; Lin, M. W. ; Huang, C. H. ; Chen, C. C. ; Lee, D. D. ; Wang, W. J. ; Hu, Jun-Hung ; Tsai, S. F. / No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis. In: Clinical and Experimental Dermatology. 2006 ; Vol. 31, No. 3. pp. 419-423.
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