No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

C. J. Hu, S. M. Sung, H. C. Liu, K. Y. Lee, W. C. Hsu, W. K. Wong, C. C. Lee, C. H. Tsai, Jan Gowth Chang

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.

Original languageEnglish
Pages (from-to)642-643
Number of pages2
JournalNeurology
Volume53
Issue number3
Publication statusPublished - Aug 11 1999
Externally publishedYes

Fingerprint

alpha-Macroglobulins
Taiwan
Gene Frequency
Nucleotides
Population
Genes
Alleles
Odds Ratio
Control Groups

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hu, C. J., Sung, S. M., Liu, H. C., Lee, K. Y., Hsu, W. C., Wong, W. K., ... Chang, J. G. (1999). No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese. Neurology, 53(3), 642-643.

No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese. / Hu, C. J.; Sung, S. M.; Liu, H. C.; Lee, K. Y.; Hsu, W. C.; Wong, W. K.; Lee, C. C.; Tsai, C. H.; Chang, Jan Gowth.

In: Neurology, Vol. 53, No. 3, 11.08.1999, p. 642-643.

Research output: Contribution to journalArticle

Hu, CJ, Sung, SM, Liu, HC, Lee, KY, Hsu, WC, Wong, WK, Lee, CC, Tsai, CH & Chang, JG 1999, 'No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese', Neurology, vol. 53, no. 3, pp. 642-643.
Hu CJ, Sung SM, Liu HC, Lee KY, Hsu WC, Wong WK et al. No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese. Neurology. 1999 Aug 11;53(3):642-643.
Hu, C. J. ; Sung, S. M. ; Liu, H. C. ; Lee, K. Y. ; Hsu, W. C. ; Wong, W. K. ; Lee, C. C. ; Tsai, C. H. ; Chang, Jan Gowth. / No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese. In: Neurology. 1999 ; Vol. 53, No. 3. pp. 642-643.
@article{78d46844ddd8459e863dee5f98d4795a,
title = "No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese",
abstract = "The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95{\%} CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.",
author = "Hu, {C. J.} and Sung, {S. M.} and Liu, {H. C.} and Lee, {K. Y.} and Hsu, {W. C.} and Wong, {W. K.} and Lee, {C. C.} and Tsai, {C. H.} and Chang, {Jan Gowth}",
year = "1999",
month = "8",
day = "11",
language = "English",
volume = "53",
pages = "642--643",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - No association of alpha-2 macroglobulin gene five-nucleotide deletion with AD in Taiwan Chinese

AU - Hu, C. J.

AU - Sung, S. M.

AU - Liu, H. C.

AU - Lee, K. Y.

AU - Hsu, W. C.

AU - Wong, W. K.

AU - Lee, C. C.

AU - Tsai, C. H.

AU - Chang, Jan Gowth

PY - 1999/8/11

Y1 - 1999/8/11

N2 - The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.

AB - The alpha-2 macroglobulin five-nucleotide deletion (A2M-2) allele frequency was not significantly higher in the AD group than the control group (0.062 versus 0.101, p > 0.1). The odds ratio for AD in individuals with the A2M-2 allele was 0.582 (95% CI, 0.25 to 1.40). These results do not support the association between A2M-2 and AD in the Chinese population, although the allele frequency of A2M-2 is lower than that found in the Caucasian population. Therefore, A2M-2 might not be a significant risk factor of AD among Taiwan Chinese.

UR - http://www.scopus.com/inward/record.url?scp=0033546616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033546616&partnerID=8YFLogxK

M3 - Article

C2 - 10449138

AN - SCOPUS:0033546616

VL - 53

SP - 642

EP - 643

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 3

ER -