NMR chemical shift assignments of a complex between SUMO-1 and SIM peptide derived from the C-terminus of Daxx

Mandar T. Naik, Che Chang Chang, Nandita M. Naik, Camy C H Kung, Hsiu Ming Shih, Tai Huang Huang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Small Ubiquitin-like MOdifiers (SUMOs) are ubiquitin-like proteins known to covalently modify large number of cellular proteins. The mammalian SUMO family includes four paralogues, SUMO-1 through SUMO-4. Death-associated protein-6, Daxx, is a 740 residue important transcription corepressor known to represses transcriptional potential of several sumolyted transcription factors. Daxx also plays important role in apoptosis. Both terminals of Daxx harbor separate SUMO Interaction Motifs (SIM), which mediate its interaction with SUMO and hence the sumolyted transcription factors. The C-terminal SIM of Daxx preferentially binds SUMO-1. Practically complete 1H, 13C and 15N resonance assignments for the complex between SUMO-1 and 20 residue Daxx C-terminal SIM peptide are reported here.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalBiomolecular NMR Assignments
Volume5
Issue number1
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

Fingerprint

Chemical shift
Ubiquitin
Nuclear magnetic resonance
Peptides
Transcription Factors
Ubiquitins
Co-Repressor Proteins
polypeptide C
Transcription
Ports and harbors
Proteins
Apoptosis

Keywords

  • Daxx
  • Promyelocytic leukemia
  • SUMO
  • SUMO interaction motif

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

Cite this

NMR chemical shift assignments of a complex between SUMO-1 and SIM peptide derived from the C-terminus of Daxx. / Naik, Mandar T.; Chang, Che Chang; Naik, Nandita M.; Kung, Camy C H; Shih, Hsiu Ming; Huang, Tai Huang.

In: Biomolecular NMR Assignments, Vol. 5, No. 1, 04.2011, p. 75-77.

Research output: Contribution to journalArticle

Naik, Mandar T. ; Chang, Che Chang ; Naik, Nandita M. ; Kung, Camy C H ; Shih, Hsiu Ming ; Huang, Tai Huang. / NMR chemical shift assignments of a complex between SUMO-1 and SIM peptide derived from the C-terminus of Daxx. In: Biomolecular NMR Assignments. 2011 ; Vol. 5, No. 1. pp. 75-77.
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