NMDA inhibits oxotremorine-induced acid secretion via the NO-dependent cyclic GMP system in rat stomach

L. H. Tsai, Y. J. Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The mechanism of N-methyl-D-aspartate (NMDA) inhibits oxotremorine-induced acid secretion was examined in rat stomach, in relation to the cyclic GMP system. NMDA (10 -7 M) did not affect the spontaneous acid secretion from the everted preparations of isolated rat stomach, but inhibited the acid secretion stimulated by oxotremorine, and this effect of NMDA was antagonized by 2-amino-5-phosphonovaleric acid (AP-5), (±)3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) or N G-nitro-L-arginine (L-NNA). NMDA also elevated the cyclic GMP content of mucosal slices from rat stomach, and this effect of NMDA was antagonized by L-NNA. These results indicate that NMDA receptors are present in the rat stomach and regulate the gastric acid secretion. The mechanism underlying the effect of NMDA inhibits oxotremorine-induced acid secretion may be mediated by the NO-dependent cyclic GMP system.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalChinese Journal of Physiology
Volume44
Issue number4
Publication statusPublished - 2001

Fingerprint

Oxotremorine
Cyclic GMP
N-Methylaspartate
Stomach
Acids
2-Amino-5-phosphonovalerate
Gastric Acid
N-Methyl-D-Aspartate Receptors
Arginine

Keywords

  • Acid secretion
  • Cyclic GMP
  • N-methyl-D-aspartate (NMDA)
  • Nitric oxide

ASJC Scopus subject areas

  • Physiology

Cite this

NMDA inhibits oxotremorine-induced acid secretion via the NO-dependent cyclic GMP system in rat stomach. / Tsai, L. H.; Lee, Y. J.

In: Chinese Journal of Physiology, Vol. 44, No. 4, 2001, p. 193-198.

Research output: Contribution to journalArticle

@article{db1231aa41b043108031404c005457b4,
title = "NMDA inhibits oxotremorine-induced acid secretion via the NO-dependent cyclic GMP system in rat stomach",
abstract = "The mechanism of N-methyl-D-aspartate (NMDA) inhibits oxotremorine-induced acid secretion was examined in rat stomach, in relation to the cyclic GMP system. NMDA (10 -7 M) did not affect the spontaneous acid secretion from the everted preparations of isolated rat stomach, but inhibited the acid secretion stimulated by oxotremorine, and this effect of NMDA was antagonized by 2-amino-5-phosphonovaleric acid (AP-5), (±)3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) or N G-nitro-L-arginine (L-NNA). NMDA also elevated the cyclic GMP content of mucosal slices from rat stomach, and this effect of NMDA was antagonized by L-NNA. These results indicate that NMDA receptors are present in the rat stomach and regulate the gastric acid secretion. The mechanism underlying the effect of NMDA inhibits oxotremorine-induced acid secretion may be mediated by the NO-dependent cyclic GMP system.",
keywords = "Acid secretion, Cyclic GMP, N-methyl-D-aspartate (NMDA), Nitric oxide",
author = "Tsai, {L. H.} and Lee, {Y. J.}",
year = "2001",
language = "English",
volume = "44",
pages = "193--198",
journal = "Chinese Journal of Physiology",
issn = "0304-4920",
publisher = "Chinese Physiological Society",
number = "4",

}

TY - JOUR

T1 - NMDA inhibits oxotremorine-induced acid secretion via the NO-dependent cyclic GMP system in rat stomach

AU - Tsai, L. H.

AU - Lee, Y. J.

PY - 2001

Y1 - 2001

N2 - The mechanism of N-methyl-D-aspartate (NMDA) inhibits oxotremorine-induced acid secretion was examined in rat stomach, in relation to the cyclic GMP system. NMDA (10 -7 M) did not affect the spontaneous acid secretion from the everted preparations of isolated rat stomach, but inhibited the acid secretion stimulated by oxotremorine, and this effect of NMDA was antagonized by 2-amino-5-phosphonovaleric acid (AP-5), (±)3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) or N G-nitro-L-arginine (L-NNA). NMDA also elevated the cyclic GMP content of mucosal slices from rat stomach, and this effect of NMDA was antagonized by L-NNA. These results indicate that NMDA receptors are present in the rat stomach and regulate the gastric acid secretion. The mechanism underlying the effect of NMDA inhibits oxotremorine-induced acid secretion may be mediated by the NO-dependent cyclic GMP system.

AB - The mechanism of N-methyl-D-aspartate (NMDA) inhibits oxotremorine-induced acid secretion was examined in rat stomach, in relation to the cyclic GMP system. NMDA (10 -7 M) did not affect the spontaneous acid secretion from the everted preparations of isolated rat stomach, but inhibited the acid secretion stimulated by oxotremorine, and this effect of NMDA was antagonized by 2-amino-5-phosphonovaleric acid (AP-5), (±)3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) or N G-nitro-L-arginine (L-NNA). NMDA also elevated the cyclic GMP content of mucosal slices from rat stomach, and this effect of NMDA was antagonized by L-NNA. These results indicate that NMDA receptors are present in the rat stomach and regulate the gastric acid secretion. The mechanism underlying the effect of NMDA inhibits oxotremorine-induced acid secretion may be mediated by the NO-dependent cyclic GMP system.

KW - Acid secretion

KW - Cyclic GMP

KW - N-methyl-D-aspartate (NMDA)

KW - Nitric oxide

UR - http://www.scopus.com/inward/record.url?scp=0035668693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035668693&partnerID=8YFLogxK

M3 - Article

VL - 44

SP - 193

EP - 198

JO - Chinese Journal of Physiology

JF - Chinese Journal of Physiology

SN - 0304-4920

IS - 4

ER -