Nitric oxide is associated with poor embryo quality and pregnancy outcome in in vitro fertilization cycles

Tsung Hsien Lee, Ming Yih Wu, Mei Jou Chen, Kuang Han Chao, Hong Nerng Ho, Yu Shih Yang

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Objective To evaluate the association between follicular and serum nitric oxide (NO) levels and embryo development and outcome in IVF. Design Prospective, case-control study. Setting University hospital, tertiary medical center. Patient(s) Eighteen patients with tubal or peritoneal factor infertility and 18 female partners from couples with male factor infertility underwent controlled ovarian stimulation and IVF/intracytoplasmic sperm injection (ICSI). Intervention(s) Controlled ovarian stimulation and oocyte retrieval followed by IVF/ICSI and embryo culture. Main outcome measure(s) Degree of fragmentation of embryos and pregnancy rate. Result(s) Higher follicular NO levels were associated with advanced fragmentation of embryos. Follicular soluble Fas could not prevent embryo fragmentation. Higher serum NO levels were found among nonpregnant patients with tubal or peritoneal factor infertility. No elevated serum NO levels were found in the female partners from couples with male factor infertility. Conclusion(s) Up-regulation of serum NO is associated with implantation failure in patients with tubal or peritoneal factor infertility.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalFertility and Sterility
Volume82
Issue number1
DOIs
Publication statusPublished - Jul 1 2004
Externally publishedYes

Fingerprint

Female Infertility
Ovarian Follicle
Intracytoplasmic Sperm Injections
Ovulation Induction
Male Infertility
Fertilization in Vitro
Pregnancy Outcome
Infertility
Case-Control Studies
Nitric Oxide
Embryonic Structures
Prospective Studies
Pregnancy
Serum
Oocyte Retrieval
Pregnancy Rate
Embryonic Development
Up-Regulation
Outcome Assessment (Health Care)

Keywords

  • embryo quality
  • nitric oxide
  • pregnancy
  • soluble Fas
  • Tubal infertility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Nitric oxide is associated with poor embryo quality and pregnancy outcome in in vitro fertilization cycles. / Lee, Tsung Hsien; Wu, Ming Yih; Chen, Mei Jou; Chao, Kuang Han; Ho, Hong Nerng; Yang, Yu Shih.

In: Fertility and Sterility, Vol. 82, No. 1, 01.07.2004, p. 126-131.

Research output: Contribution to journalArticle

Lee, Tsung Hsien ; Wu, Ming Yih ; Chen, Mei Jou ; Chao, Kuang Han ; Ho, Hong Nerng ; Yang, Yu Shih. / Nitric oxide is associated with poor embryo quality and pregnancy outcome in in vitro fertilization cycles. In: Fertility and Sterility. 2004 ; Vol. 82, No. 1. pp. 126-131.
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