Nitric oxide and upper airway

H. W. Wang, W. Y. Su

Research output: Contribution to journalArticle

Abstract

Nitric oxide is formed in cells by the enzyme known as NO synthase (NOS). Three isoforms of NOS are now known to exist. They are nNOS, iNOS and eNOS. In normal persons, a large NO production takes place in the epithelium of paranasal sinuses and this NO contributes considerably to the levels of NO found in nasally exhaled air. The high local NO concentrations in nasal airways and the sinuses may help to protect the airway against airborne infectious agent. Thus, airborne NO may represent first line of defence in the airways, possible acting on pathogens, even before they reach the mucosa. On the other hand, inhaled endogenous NO, derived from the upper airway, may be involved in regulation of pulmonary function in human.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalJournal of the Otolaryngological Society of the Republic of China
Volume33
Issue number4
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Paranasal Sinuses
Nitric Oxide Synthase
Nitric Oxide
Protein Isoforms
Mucous Membrane
Epithelium
Air
Lung
Enzymes

Keywords

  • Nitric oxide
  • Upper airway

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Nitric oxide and upper airway. / Wang, H. W.; Su, W. Y.

In: Journal of the Otolaryngological Society of the Republic of China, Vol. 33, No. 4, 1998, p. 363-367.

Research output: Contribution to journalArticle

@article{c4146a3babe44c12bbed223268f39b14,
title = "Nitric oxide and upper airway",
abstract = "Nitric oxide is formed in cells by the enzyme known as NO synthase (NOS). Three isoforms of NOS are now known to exist. They are nNOS, iNOS and eNOS. In normal persons, a large NO production takes place in the epithelium of paranasal sinuses and this NO contributes considerably to the levels of NO found in nasally exhaled air. The high local NO concentrations in nasal airways and the sinuses may help to protect the airway against airborne infectious agent. Thus, airborne NO may represent first line of defence in the airways, possible acting on pathogens, even before they reach the mucosa. On the other hand, inhaled endogenous NO, derived from the upper airway, may be involved in regulation of pulmonary function in human.",
keywords = "Nitric oxide, Upper airway",
author = "Wang, {H. W.} and Su, {W. Y.}",
year = "1998",
language = "English",
volume = "33",
pages = "363--367",
journal = "Journal of Taiwan Otolaryngology - Head and Neck Surgery",
issn = "1019-6102",
publisher = "臺灣耳鼻喉科醫學會",
number = "4",

}

TY - JOUR

T1 - Nitric oxide and upper airway

AU - Wang, H. W.

AU - Su, W. Y.

PY - 1998

Y1 - 1998

N2 - Nitric oxide is formed in cells by the enzyme known as NO synthase (NOS). Three isoforms of NOS are now known to exist. They are nNOS, iNOS and eNOS. In normal persons, a large NO production takes place in the epithelium of paranasal sinuses and this NO contributes considerably to the levels of NO found in nasally exhaled air. The high local NO concentrations in nasal airways and the sinuses may help to protect the airway against airborne infectious agent. Thus, airborne NO may represent first line of defence in the airways, possible acting on pathogens, even before they reach the mucosa. On the other hand, inhaled endogenous NO, derived from the upper airway, may be involved in regulation of pulmonary function in human.

AB - Nitric oxide is formed in cells by the enzyme known as NO synthase (NOS). Three isoforms of NOS are now known to exist. They are nNOS, iNOS and eNOS. In normal persons, a large NO production takes place in the epithelium of paranasal sinuses and this NO contributes considerably to the levels of NO found in nasally exhaled air. The high local NO concentrations in nasal airways and the sinuses may help to protect the airway against airborne infectious agent. Thus, airborne NO may represent first line of defence in the airways, possible acting on pathogens, even before they reach the mucosa. On the other hand, inhaled endogenous NO, derived from the upper airway, may be involved in regulation of pulmonary function in human.

KW - Nitric oxide

KW - Upper airway

UR - http://www.scopus.com/inward/record.url?scp=0031703712&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031703712&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031703712

VL - 33

SP - 363

EP - 367

JO - Journal of Taiwan Otolaryngology - Head and Neck Surgery

JF - Journal of Taiwan Otolaryngology - Head and Neck Surgery

SN - 1019-6102

IS - 4

ER -