Night time resistance exercise alters muscular IL-6-related protein signaling, but not muscle growth after 10 weeks of resistance training in male rats

Chung Pu Chi, Chieh Wen Hou, Yu You Wu, Tong Hong Wang, Szu Hsien Yu

Research output: Contribution to journalArticle

Abstract

The present study investigated the time-of-day effects on acute response and chronic adaptations to resistance exercise (RE) in rat skeletal muscle. Male rats were divided into Early and Late training groups and performed climbing RE during the first or last hour of the active (dark) period, respectively. The first experiment measured muscle mass and strength after a 10-week climbing training program. The second experiment examined inflammatory signaling response and satellite cell (SC) numbers following an acute bout of RE. The results showed no significant differences between rats training at early and late active periods in relative muscle weight (muscle-to-weight ratio), cross sectional area (CSA) and strength. The acute study observed increased STAT1 phosphorylation, oxidative stress (2-thiobarbituric acid reacting substances, TBARS), SCs (Pax7+), neutrophils (His48+) and macrophages (CD68+), and decreased interleukin 6 (IL-6) protein expression of skeletal muscle relative to non-exercise control after an acute bout of RE. Interestingly, higher plasma IL-6 and STAT3 phosphorylation response was observed in the late training group when compared to the early training group after an acute bout of RE. The results of this study suggest that animals can adapt to resistance training at different time-of-day, by modulating inflammatory signaling of skeletal muscle.

Original languageEnglish
Pages (from-to)89-98
Number of pages10
JournalGeneral Physiology and Biophysics
Volume39
Issue number1
DOIs
Publication statusPublished - Jan 1 2020

Keywords

  • Circadian variation
  • Satellite cell
  • Training adaptation

ASJC Scopus subject areas

  • Biophysics
  • Physiology

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