Nicotine-induced hyperlocomotion is not modified by the estrous cycle, ovariectomy and estradiol replacement at physiological level

Dong Yih Kuo, Tzer Bin Lin, Chiun Chien Huang, Sheau Ling Duh, Jiuan Miau Liao, Juei Tang Cheng

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The present study was designed to investigate whether nicotine's effect on locomotion might be modulated by the ovarian hormone at physiological level. Rats at normal cycling of estrus and diestrus were selected for the comparison of nicotine-induced hyperlocomotion based on the document that the release of striatal dopamine was greatest at the estrous phase. Ovariectomized rats primed with or without estrogen at physiological level were also selected for comparison. Increase in spontaneous locomotion by nicotine was statistically significant at the doses of 0.15 and 0.3 mg/kg (P

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalChinese Journal of Physiology
Volume42
Issue number2
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Dopaminergic system
  • Estrous cycle
  • Locomotor behavior
  • Nicotine
  • Ovariectomy

ASJC Scopus subject areas

  • Physiology

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