Newly diagnosed major depressive disorder and the risk of erectile dysfunction: A population-based cohort study in Taiwan

Shiau Shian Huang, Ching Heng Lin, Chin Hong Chan, El Wui Loh, Tsuo Hung Lan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Introduction: The primary aim of this study was to explore the incidence rate of erectile dysfunction (ED) among major depressive disorder (MDD) patients in an Asian country. The second aim was to compare the risk of ED in MDD patients that were treated using antidepressants with a high risk-ED, antidepressants with a low risk-ED, or without treatment. Methods: We identified 4339 male patients with newly diagnosed MDD using the National Health Database. Four matched controls per case were selected for the study. Results: The mean age of the participants was 42.3±16.9. A higher crude HR of 3.6 (95% CI: 2.8-4.6) was seen in the male patients with MDD. After adjusting for obesity, monthly income, urbanization level, and comorbidity, the MDD patients had a 3.2-fold higher HR for an ED diagnosis than the controls. Patients with untreated depression had the highest risk of ED, compared to the control group (HR=3.9). Patients treated with IHiRA had a medium risk of developing ED (HR=3.6), and patients treated with ILoRA had the lowest risk of ED (HR: 2.5). Conclusion: This prospective cohort study found an association between ED and prior MDD. Patients with untreated depression may have the highest risk of developing ED.

Original languageEnglish
Pages (from-to)601-606
Number of pages6
JournalPsychiatry Research
Volume210
Issue number2
DOIs
Publication statusPublished - Dec 15 2013
Externally publishedYes

Fingerprint

Major Depressive Disorder
Erectile Dysfunction
Taiwan
Cohort Studies
Population
Antidepressive Agents
Depression
Urbanization
Comorbidity
Obesity
Databases
Prospective Studies
Control Groups
Incidence
Health

Keywords

  • Antidepressants
  • Erectile dysfunction
  • Major depressive disorder
  • Untreated depression

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Newly diagnosed major depressive disorder and the risk of erectile dysfunction : A population-based cohort study in Taiwan. / Huang, Shiau Shian; Lin, Ching Heng; Chan, Chin Hong; Loh, El Wui; Lan, Tsuo Hung.

In: Psychiatry Research, Vol. 210, No. 2, 15.12.2013, p. 601-606.

Research output: Contribution to journalArticle

Huang, Shiau Shian ; Lin, Ching Heng ; Chan, Chin Hong ; Loh, El Wui ; Lan, Tsuo Hung. / Newly diagnosed major depressive disorder and the risk of erectile dysfunction : A population-based cohort study in Taiwan. In: Psychiatry Research. 2013 ; Vol. 210, No. 2. pp. 601-606.
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