Newly diagnosed erectile dysfunction and risk of depression: A population-based 5-year follow-up study in taiwan

Ping-Song Chou, Wei-Po Chou, Ming-Chao Chen, Chiou-Lian Lai, Yu-Ching Wen, Kun-Chieh Yeh, Wei Pin Chang, Yii-Her Chou

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Introduction: Depression might increase the risk of erectile dysfunction (ED), and ED might further exacerbate depression. The causal relationship between these two diseases remains controversial. In addition, limited evidence is available regarding the age-dependent and time-dependent effects on the association of depression and ED. Aim: We investigated the hypothesis that ED increases the risk of depression by using a nationwide Taiwanese population-based claims database. In addition, we assessed the age-dependent and time-dependent effects on the association of depression and ED. Methods: A longitudinal cohort study was conducted to determine the association between patients with ED and depression development during a 5-year follow-up period, using claims data from the Taiwanese National Health Insurance Research Database. Main Outcome Measures: The study cohort comprised patients who were diagnosed with ED during 1997 to 2005 (N=2,527). For a comparison cohort, 5 age- and sex-matched patients for every patient in the study cohort were selected using random sampling (N=12,635). All of the patients were followed-up for 5 years from the date of cohort entry to identify the development of depression. Results: The main finding of this study was that patients with ED are at an increased risk of developing depression. The adjusted hazard ratio (AHR) for depression was 2.24-fold higher in the patients with ED than in the comparison cohort (95% confidence interval [CI]: 1.83-2.74; P
Original languageEnglish
Pages (from-to)804-812
Number of pages9
JournalJournal of Sexual Medicine
Volume12
Issue number3
DOIs
Publication statusPublished - 2015

Fingerprint

Erectile Dysfunction
Taiwan
Depression
Population
Cohort Studies
Databases
National Health Programs
Longitudinal Studies
Outcome Assessment (Health Care)
Confidence Intervals
Research

Keywords

  • Depression
  • Erectile dysfunction
  • Population-based study
  • Taiwan national health insurance research database
  • Taiwan population
  • adult
  • aged
  • Article
  • cohort analysis
  • comparative study
  • depression
  • diabetes mellitus
  • erectile dysfunction
  • follow up
  • human
  • hyperlipidemia
  • hypertension
  • ICD-9-CM
  • major clinical study
  • male
  • middle aged
  • national health insurance
  • priority journal
  • Taiwanese
  • urbanization
  • Cardiovascular Diseases
  • comorbidity
  • health survey
  • incidence
  • longitudinal study
  • metabolic syndrome X
  • pathophysiology
  • psychology
  • risk factor
  • Taiwan
  • antidepressant agent
  • Adult
  • Aged
  • Antidepressive Agents
  • Cohort Studies
  • Comorbidity
  • Erectile Dysfunction
  • Follow-Up Studies
  • Humans
  • Hypertension
  • Incidence
  • Longitudinal Studies
  • Male
  • Metabolic Syndrome X
  • Middle Aged
  • Population Surveillance
  • Risk Factors

Cite this

Newly diagnosed erectile dysfunction and risk of depression: A population-based 5-year follow-up study in taiwan. / Chou, Ping-Song; Chou, Wei-Po; Chen, Ming-Chao; Lai, Chiou-Lian; Wen, Yu-Ching; Yeh, Kun-Chieh; Chang, Wei Pin; Chou, Yii-Her.

In: Journal of Sexual Medicine, Vol. 12, No. 3, 2015, p. 804-812.

Research output: Contribution to journalArticle

Chou, Ping-Song ; Chou, Wei-Po ; Chen, Ming-Chao ; Lai, Chiou-Lian ; Wen, Yu-Ching ; Yeh, Kun-Chieh ; Chang, Wei Pin ; Chou, Yii-Her. / Newly diagnosed erectile dysfunction and risk of depression: A population-based 5-year follow-up study in taiwan. In: Journal of Sexual Medicine. 2015 ; Vol. 12, No. 3. pp. 804-812.
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abstract = "Introduction: Depression might increase the risk of erectile dysfunction (ED), and ED might further exacerbate depression. The causal relationship between these two diseases remains controversial. In addition, limited evidence is available regarding the age-dependent and time-dependent effects on the association of depression and ED. Aim: We investigated the hypothesis that ED increases the risk of depression by using a nationwide Taiwanese population-based claims database. In addition, we assessed the age-dependent and time-dependent effects on the association of depression and ED. Methods: A longitudinal cohort study was conducted to determine the association between patients with ED and depression development during a 5-year follow-up period, using claims data from the Taiwanese National Health Insurance Research Database. Main Outcome Measures: The study cohort comprised patients who were diagnosed with ED during 1997 to 2005 (N=2,527). For a comparison cohort, 5 age- and sex-matched patients for every patient in the study cohort were selected using random sampling (N=12,635). All of the patients were followed-up for 5 years from the date of cohort entry to identify the development of depression. Results: The main finding of this study was that patients with ED are at an increased risk of developing depression. The adjusted hazard ratio (AHR) for depression was 2.24-fold higher in the patients with ED than in the comparison cohort (95{\%} confidence interval [CI]: 1.83-2.74; P",
keywords = "Depression, Erectile dysfunction, Population-based study, Taiwan national health insurance research database, Taiwan population, adult, aged, Article, cohort analysis, comparative study, depression, diabetes mellitus, erectile dysfunction, follow up, human, hyperlipidemia, hypertension, ICD-9-CM, major clinical study, male, middle aged, national health insurance, priority journal, Taiwanese, urbanization, Cardiovascular Diseases, comorbidity, health survey, incidence, longitudinal study, metabolic syndrome X, pathophysiology, psychology, risk factor, Taiwan, antidepressant agent, Adult, Aged, Antidepressive Agents, Cohort Studies, Comorbidity, Erectile Dysfunction, Follow-Up Studies, Humans, Hypertension, Incidence, Longitudinal Studies, Male, Metabolic Syndrome X, Middle Aged, Population Surveillance, Risk Factors",
author = "Ping-Song Chou and Wei-Po Chou and Ming-Chao Chen and Chiou-Lian Lai and Yu-Ching Wen and Kun-Chieh Yeh and Chang, {Wei Pin} and Yii-Her Chou",
note = "被引用次數:1 Export Date: 25 March 2016 通訊地址: Chou, Y.-H.; Department of Urology, Kaohsiung Medical University Hospital, No.100, Tzyou 1st Road, Taiwan 化學物質/CAS: Antidepressive Agents 參考文獻: Impotence. NIH consensus development panel on impotence (1993) JAMA, 270, pp. 83-90; Lewis, R.W., Epidemiology of sexual dysfunction in Asia compared to the rest of the world (2011) Asian J Androl, 13, pp. 152-158; Giuliano, F., Droupy, S., Erectile dysfunction (2013) Prog Urol, 23, pp. 629-637; Melman, A., Gingell, J.C., The epidemiology and pathophysiology of erectile dysfunction (1999) J Urol, 161, pp. 5-11; Araujo, A.B., Durante, R., Feldman, H.A., Goldstein, I., McKinlay, J.B., The relationship between depressive symptoms and male erectile dysfunction: Cross-sectional results from the Massachusetts Male Aging Study (1998) Psychosom Med, 60, pp. 458-465; Shabsigh, R., Klein, L.T., Seidman, S., Kaplan, S.A., Lehrhoff, B.J., Ritter, J.S., Increased incidence of depressive symptoms in men with erectile dysfunction (1998) Urology, 52, pp. 848-852; Seftel, A.D., Sun, P., Swindle, R., The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction (2004) J Urol, 171, pp. 2341-2345; Nicolosi, A., Moreira Jr, E.D., Villa, M., Glasser, D.B., A population study of the association between sexual function, sexual satisfaction and depressive symptoms in men (2004) J Affect Disord, 82, pp. 235-243; Huang, S.S., Lin, C.H., Chan, C.H., Loh, E.-W., Lan, T.H., Newly diagnosed major depressive disorder and the risk of erectile dysfunction: A population-based cohort study in Taiwan (2013) Psychiatry Res, 210, pp. 601-606; Shiri, R., Koskimaki, J., Tammela, T.L., Hakkinen, J., Auvinen, A., Hakama, M., Bidirectional relationship between depression and erectile dysfunction (2007) J Urol, 177, pp. 669-673; Shabsigh, R., Arver, S., Channer, K.S., Eardley, I., Fabbri, A., Gooren, L., Heufelder, A., Zitzmann, M., The triad of erectile dysfunction, hypogonadism and the metabolic syndrome (2008) Int J Clin Pract, 62, pp. 791-798; Tsujimura, A., The relationship between testosterone deficiency and men's health (2013) World J Mens Health, 31, pp. 126-135; Hwang, T.I., Lin, Y.C., The relationship between hypogonadism and erectile dysfunction (2008) Int J Impot Res, 20, pp. 231-235; Shi, Z., Araujo, A.B., Martin, S., O'Loughlin, P., Wittert, G.A., Longitudinal changes in testosterone over five years in community-dwelling men (2013) J Clin Endocrinol Metab, 98, pp. 3289-3297; Khera, M., Patients with testosterone deficit syndrome and depression (2013) Arch Esp Urol, 66, pp. 729-736; Joshi, D., van Schoor, N.M., de Ronde, W., Schaap, L.A., Comijs, H.C., Beekman, A.T., Lips, P., Low free testosterone levels are associated with prevalence and incidence of depressive symptoms in older men (2010) Clin Endocrinol (Oxf), 72, pp. 232-240; Lasaite, L., Ceponis, J., Preiksa, R.T., Zilaitiene, B., Impaired emotional state, quality of life and cognitive functions in young hypogonadal men (2013) Andrologia; Corona, G., Mannucci, E., Jannini, E.A., Lotti, F., Ricca, V., Monami, M., Boddi, V., Maggi, M., Hypoprolactinemia: A new clinical syndrome in patients with sexual dysfunction (2009) J Sex Med, 6, pp. 1457-1466; Corona, G., Wu, F.C., Rastrelli, G., Lee, D.M., Forti, G., O'Connor, D.B., O'Neill, T.W., Maggi, M., Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: The European Male Aging Study (EMAS) (2014) J Sex Med, 11, pp. 240-253; Yao, F., Huang, Y., Zhang, Y., Dong, Y., Ma, H., Deng, C., Lin, H., Lu, K., Subclinical endothelial dysfunction and low-grade inflammation play roles in the development of erectile dysfunction in young men with low risk of coronary heart disease (2012) Int J Androl, 35, pp. 653-659; Vlachopoulos, C., Aznaouridis, K., Ioakeimidis, N., Rokkas, K., Vasiliadou, C., Alexopoulos, N., Stefanadi, E., Stefanadis, C., Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease (2006) Eur Heart J, 27, pp. 2640-2648; Ara{\~n}a Rosa{\'i}nz Mde, J., Ojeda, M.O., Acosta, J.R., El{\'i}as-Calles, L.C., Gonz{\'a}lez, N.O., Herrera, O.T., Garc{\'i}a {\'A}lvarez, C.T., Vald{\'e}s, R.F., Imbalanced low-grade inflammation and endothelial activation in patients with type 2 diabetes mellitus and erectile dysfunction (2011) J Sex Med, 8, pp. 2017-2030; Cooper, D.C., Tomfohr, L.M., Milic, M.S., Natarajan, L., Bardwell, W.A., Ziegler, M.G., Dimsdale, J.E., Depressed mood and flow-mediated dilation: A systematic review and meta-analysis (2011) Psychosom Med, 73, pp. 360-369; Pizzi, C., Manzoli, L., Mancini, S., Costa, G.M., Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate variability, markers of inflammation, and endothelial function (2008) Eur Heart J, 29, pp. 1110-1117; Raedler, T.J., Inflammatory mechanisms in major depressive disorder (2011) Curr Opin Psychiatry, 24, pp. 519-525; Patel, A., Review: The role of inflammation in depression (2013) Psychiatr Danub, 25 (3), pp. S216-S223; Vlachopoulos, C., Ioakeimidis, N., Terentes-Printzios, D., Stefanadis, C., The triad: Erectile dysfunction-endothelial dysfunction-cardiovascular disease (2008) Curr Pharm Des, 14, pp. 3700-3714; Gandaglia, G., Briganti, A., Jackson, G., Kloner, R.A., Montorsi, F., Montorsi, P., Vlachopoulos, C.A., Systematic review of the association between erectile dysfunction and cardiovascular disease (2013) Eur Urol, 65, pp. 968-978; Meng, L., Chen, D., Yang, Y., Zheng, Y., Hui, R., Depression increases the risk of hypertension incidence: A meta-analysis of prospective cohort studies (2012) J Hypertens, 30, pp. 842-851; van Dooren, F.E., Nefs, G., Schram, M.T., Verhey, F.R., Denollet, J., Pouwer, F., Depression and risk of mortality in people with diabetes mellitus: A systematic review and meta-analysis (2013) PLoS ONE, 8, p. e57058; Nouwen, A., Winkley, K., Twisk, J., Lloyd, C.E., Peyrot, M., Ismail, K., Pouwer, F., Type 2 diabetes mellitus as a risk factor for the onset of depression: A systematic review and meta-analysis (2010) Diabetologia, 53, pp. 2480-2486; Pan, A., Keum, N., Okereke, O.I., Sun, Q., Kivimaki, M., Rubin, R.R., Hu, F.B., Bidirectional association between depression and metabolic syndrome: A systematic review and meta-analysis of epidemiological studies (2012) Diabetes Care, 35, pp. 1171-1180; Pan, A., Sun, Q., Okereke, O.I., Rexrode, K.M., Hu, F.B., Depression and risk of stroke morbidity and mortality: A meta-analysis and systematic review (2011) JAMA, 306, pp. 1241-1249; Goldstein, I., The mutually reinforcing triad of depressive symptoms, cardiovascular disease, and erectile dysfunction (2000) Am J Cardiol, 86 A (2), pp. 41F-45F; Lee, J.Y., Joo, K.J., Kim, J.T., Cho, S.T., Cho, D.S., Won, Y.Y., Choi, J.B., Heart rate variability in men with erectile dysfunction (2011) Int Neurourol J, 15, pp. 87-91; Lau, J.T., Kim, J.H., Tsui, H.Y., Prevalence of male and female sexual problems, perceptions related to sex and association with quality of life in a Chinese population: A population-based study (2005) Int J Impot Res, 17, pp. 494-505; Sanchez-Cruz, J.J., Cabrera-Leon, A., Martin-Morales, A., Fernandez, A., Burgos, R., Rejas, J., Male erectile dysfunction and health-related quality of life (2003) Eur Urol, 44, pp. 245-253; Litwin, M.S., Nied, R.J., Dhanani, N., Health-related quality of life in men with erectile dysfunction (1998) J Gen Intern Med, 13, pp. 159-166; Seidman, S.N., Roose, S.P., Menza, M.A., Shabsigh, R., Rosen, R.C., Treatment of erectile dysfunction in men with depressive symptoms: Results of a placebo-controlled trial with sildenafil citrate (2001) Am J Psychiatry, 158, pp. 1623-1630",
year = "2015",
doi = "10.1111/jsm.12792",
language = "English",
volume = "12",
pages = "804--812",
journal = "Journal of Sexual Medicine",
issn = "1743-6095",
publisher = "Blackwell Publishing Ltd",
number = "3",

}

TY - JOUR

T1 - Newly diagnosed erectile dysfunction and risk of depression: A population-based 5-year follow-up study in taiwan

AU - Chou, Ping-Song

AU - Chou, Wei-Po

AU - Chen, Ming-Chao

AU - Lai, Chiou-Lian

AU - Wen, Yu-Ching

AU - Yeh, Kun-Chieh

AU - Chang, Wei Pin

AU - Chou, Yii-Her

N1 - 被引用次數:1 Export Date: 25 March 2016 通訊地址: Chou, Y.-H.; Department of Urology, Kaohsiung Medical University Hospital, No.100, Tzyou 1st Road, Taiwan 化學物質/CAS: Antidepressive Agents 參考文獻: Impotence. NIH consensus development panel on impotence (1993) JAMA, 270, pp. 83-90; Lewis, R.W., Epidemiology of sexual dysfunction in Asia compared to the rest of the world (2011) Asian J Androl, 13, pp. 152-158; Giuliano, F., Droupy, S., Erectile dysfunction (2013) Prog Urol, 23, pp. 629-637; Melman, A., Gingell, J.C., The epidemiology and pathophysiology of erectile dysfunction (1999) J Urol, 161, pp. 5-11; Araujo, A.B., Durante, R., Feldman, H.A., Goldstein, I., McKinlay, J.B., The relationship between depressive symptoms and male erectile dysfunction: Cross-sectional results from the Massachusetts Male Aging Study (1998) Psychosom Med, 60, pp. 458-465; Shabsigh, R., Klein, L.T., Seidman, S., Kaplan, S.A., Lehrhoff, B.J., Ritter, J.S., Increased incidence of depressive symptoms in men with erectile dysfunction (1998) Urology, 52, pp. 848-852; Seftel, A.D., Sun, P., Swindle, R., The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction (2004) J Urol, 171, pp. 2341-2345; Nicolosi, A., Moreira Jr, E.D., Villa, M., Glasser, D.B., A population study of the association between sexual function, sexual satisfaction and depressive symptoms in men (2004) J Affect Disord, 82, pp. 235-243; Huang, S.S., Lin, C.H., Chan, C.H., Loh, E.-W., Lan, T.H., Newly diagnosed major depressive disorder and the risk of erectile dysfunction: A population-based cohort study in Taiwan (2013) Psychiatry Res, 210, pp. 601-606; Shiri, R., Koskimaki, J., Tammela, T.L., Hakkinen, J., Auvinen, A., Hakama, M., Bidirectional relationship between depression and erectile dysfunction (2007) J Urol, 177, pp. 669-673; Shabsigh, R., Arver, S., Channer, K.S., Eardley, I., Fabbri, A., Gooren, L., Heufelder, A., Zitzmann, M., The triad of erectile dysfunction, hypogonadism and the metabolic syndrome (2008) Int J Clin Pract, 62, pp. 791-798; Tsujimura, A., The relationship between testosterone deficiency and men's health (2013) World J Mens Health, 31, pp. 126-135; Hwang, T.I., Lin, Y.C., The relationship between hypogonadism and erectile dysfunction (2008) Int J Impot Res, 20, pp. 231-235; Shi, Z., Araujo, A.B., Martin, S., O'Loughlin, P., Wittert, G.A., Longitudinal changes in testosterone over five years in community-dwelling men (2013) J Clin Endocrinol Metab, 98, pp. 3289-3297; Khera, M., Patients with testosterone deficit syndrome and depression (2013) Arch Esp Urol, 66, pp. 729-736; Joshi, D., van Schoor, N.M., de Ronde, W., Schaap, L.A., Comijs, H.C., Beekman, A.T., Lips, P., Low free testosterone levels are associated with prevalence and incidence of depressive symptoms in older men (2010) Clin Endocrinol (Oxf), 72, pp. 232-240; Lasaite, L., Ceponis, J., Preiksa, R.T., Zilaitiene, B., Impaired emotional state, quality of life and cognitive functions in young hypogonadal men (2013) Andrologia; Corona, G., Mannucci, E., Jannini, E.A., Lotti, F., Ricca, V., Monami, M., Boddi, V., Maggi, M., Hypoprolactinemia: A new clinical syndrome in patients with sexual dysfunction (2009) J Sex Med, 6, pp. 1457-1466; Corona, G., Wu, F.C., Rastrelli, G., Lee, D.M., Forti, G., O'Connor, D.B., O'Neill, T.W., Maggi, M., Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: The European Male Aging Study (EMAS) (2014) J Sex Med, 11, pp. 240-253; Yao, F., Huang, Y., Zhang, Y., Dong, Y., Ma, H., Deng, C., Lin, H., Lu, K., Subclinical endothelial dysfunction and low-grade inflammation play roles in the development of erectile dysfunction in young men with low risk of coronary heart disease (2012) Int J Androl, 35, pp. 653-659; Vlachopoulos, C., Aznaouridis, K., Ioakeimidis, N., Rokkas, K., Vasiliadou, C., Alexopoulos, N., Stefanadi, E., Stefanadis, C., Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease (2006) Eur Heart J, 27, pp. 2640-2648; Araña Rosaínz Mde, J., Ojeda, M.O., Acosta, J.R., Elías-Calles, L.C., González, N.O., Herrera, O.T., García Álvarez, C.T., Valdés, R.F., Imbalanced low-grade inflammation and endothelial activation in patients with type 2 diabetes mellitus and erectile dysfunction (2011) J Sex Med, 8, pp. 2017-2030; Cooper, D.C., Tomfohr, L.M., Milic, M.S., Natarajan, L., Bardwell, W.A., Ziegler, M.G., Dimsdale, J.E., Depressed mood and flow-mediated dilation: A systematic review and meta-analysis (2011) Psychosom Med, 73, pp. 360-369; Pizzi, C., Manzoli, L., Mancini, S., Costa, G.M., Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate variability, markers of inflammation, and endothelial function (2008) Eur Heart J, 29, pp. 1110-1117; Raedler, T.J., Inflammatory mechanisms in major depressive disorder (2011) Curr Opin Psychiatry, 24, pp. 519-525; Patel, A., Review: The role of inflammation in depression (2013) Psychiatr Danub, 25 (3), pp. S216-S223; Vlachopoulos, C., Ioakeimidis, N., Terentes-Printzios, D., Stefanadis, C., The triad: Erectile dysfunction-endothelial dysfunction-cardiovascular disease (2008) Curr Pharm Des, 14, pp. 3700-3714; Gandaglia, G., Briganti, A., Jackson, G., Kloner, R.A., Montorsi, F., Montorsi, P., Vlachopoulos, C.A., Systematic review of the association between erectile dysfunction and cardiovascular disease (2013) Eur Urol, 65, pp. 968-978; Meng, L., Chen, D., Yang, Y., Zheng, Y., Hui, R., Depression increases the risk of hypertension incidence: A meta-analysis of prospective cohort studies (2012) J Hypertens, 30, pp. 842-851; van Dooren, F.E., Nefs, G., Schram, M.T., Verhey, F.R., Denollet, J., Pouwer, F., Depression and risk of mortality in people with diabetes mellitus: A systematic review and meta-analysis (2013) PLoS ONE, 8, p. e57058; Nouwen, A., Winkley, K., Twisk, J., Lloyd, C.E., Peyrot, M., Ismail, K., Pouwer, F., Type 2 diabetes mellitus as a risk factor for the onset of depression: A systematic review and meta-analysis (2010) Diabetologia, 53, pp. 2480-2486; Pan, A., Keum, N., Okereke, O.I., Sun, Q., Kivimaki, M., Rubin, R.R., Hu, F.B., Bidirectional association between depression and metabolic syndrome: A systematic review and meta-analysis of epidemiological studies (2012) Diabetes Care, 35, pp. 1171-1180; Pan, A., Sun, Q., Okereke, O.I., Rexrode, K.M., Hu, F.B., Depression and risk of stroke morbidity and mortality: A meta-analysis and systematic review (2011) JAMA, 306, pp. 1241-1249; Goldstein, I., The mutually reinforcing triad of depressive symptoms, cardiovascular disease, and erectile dysfunction (2000) Am J Cardiol, 86 A (2), pp. 41F-45F; Lee, J.Y., Joo, K.J., Kim, J.T., Cho, S.T., Cho, D.S., Won, Y.Y., Choi, J.B., Heart rate variability in men with erectile dysfunction (2011) Int Neurourol J, 15, pp. 87-91; Lau, J.T., Kim, J.H., Tsui, H.Y., Prevalence of male and female sexual problems, perceptions related to sex and association with quality of life in a Chinese population: A population-based study (2005) Int J Impot Res, 17, pp. 494-505; Sanchez-Cruz, J.J., Cabrera-Leon, A., Martin-Morales, A., Fernandez, A., Burgos, R., Rejas, J., Male erectile dysfunction and health-related quality of life (2003) Eur Urol, 44, pp. 245-253; Litwin, M.S., Nied, R.J., Dhanani, N., Health-related quality of life in men with erectile dysfunction (1998) J Gen Intern Med, 13, pp. 159-166; Seidman, S.N., Roose, S.P., Menza, M.A., Shabsigh, R., Rosen, R.C., Treatment of erectile dysfunction in men with depressive symptoms: Results of a placebo-controlled trial with sildenafil citrate (2001) Am J Psychiatry, 158, pp. 1623-1630

PY - 2015

Y1 - 2015

N2 - Introduction: Depression might increase the risk of erectile dysfunction (ED), and ED might further exacerbate depression. The causal relationship between these two diseases remains controversial. In addition, limited evidence is available regarding the age-dependent and time-dependent effects on the association of depression and ED. Aim: We investigated the hypothesis that ED increases the risk of depression by using a nationwide Taiwanese population-based claims database. In addition, we assessed the age-dependent and time-dependent effects on the association of depression and ED. Methods: A longitudinal cohort study was conducted to determine the association between patients with ED and depression development during a 5-year follow-up period, using claims data from the Taiwanese National Health Insurance Research Database. Main Outcome Measures: The study cohort comprised patients who were diagnosed with ED during 1997 to 2005 (N=2,527). For a comparison cohort, 5 age- and sex-matched patients for every patient in the study cohort were selected using random sampling (N=12,635). All of the patients were followed-up for 5 years from the date of cohort entry to identify the development of depression. Results: The main finding of this study was that patients with ED are at an increased risk of developing depression. The adjusted hazard ratio (AHR) for depression was 2.24-fold higher in the patients with ED than in the comparison cohort (95% confidence interval [CI]: 1.83-2.74; P

AB - Introduction: Depression might increase the risk of erectile dysfunction (ED), and ED might further exacerbate depression. The causal relationship between these two diseases remains controversial. In addition, limited evidence is available regarding the age-dependent and time-dependent effects on the association of depression and ED. Aim: We investigated the hypothesis that ED increases the risk of depression by using a nationwide Taiwanese population-based claims database. In addition, we assessed the age-dependent and time-dependent effects on the association of depression and ED. Methods: A longitudinal cohort study was conducted to determine the association between patients with ED and depression development during a 5-year follow-up period, using claims data from the Taiwanese National Health Insurance Research Database. Main Outcome Measures: The study cohort comprised patients who were diagnosed with ED during 1997 to 2005 (N=2,527). For a comparison cohort, 5 age- and sex-matched patients for every patient in the study cohort were selected using random sampling (N=12,635). All of the patients were followed-up for 5 years from the date of cohort entry to identify the development of depression. Results: The main finding of this study was that patients with ED are at an increased risk of developing depression. The adjusted hazard ratio (AHR) for depression was 2.24-fold higher in the patients with ED than in the comparison cohort (95% confidence interval [CI]: 1.83-2.74; P

KW - Depression

KW - Erectile dysfunction

KW - Population-based study

KW - Taiwan national health insurance research database

KW - Taiwan population

KW - adult

KW - aged

KW - Article

KW - cohort analysis

KW - comparative study

KW - depression

KW - diabetes mellitus

KW - erectile dysfunction

KW - follow up

KW - human

KW - hyperlipidemia

KW - hypertension

KW - ICD-9-CM

KW - major clinical study

KW - male

KW - middle aged

KW - national health insurance

KW - priority journal

KW - Taiwanese

KW - urbanization

KW - Cardiovascular Diseases

KW - comorbidity

KW - health survey

KW - incidence

KW - longitudinal study

KW - metabolic syndrome X

KW - pathophysiology

KW - psychology

KW - risk factor

KW - Taiwan

KW - antidepressant agent

KW - Adult

KW - Aged

KW - Antidepressive Agents

KW - Cohort Studies

KW - Comorbidity

KW - Erectile Dysfunction

KW - Follow-Up Studies

KW - Humans

KW - Hypertension

KW - Incidence

KW - Longitudinal Studies

KW - Male

KW - Metabolic Syndrome X

KW - Middle Aged

KW - Population Surveillance

KW - Risk Factors

U2 - 10.1111/jsm.12792

DO - 10.1111/jsm.12792

M3 - Article

VL - 12

SP - 804

EP - 812

JO - Journal of Sexual Medicine

JF - Journal of Sexual Medicine

SN - 1743-6095

IS - 3

ER -