Newly diagnosed erectile dysfunction and risk of depression: A population-based 5-year follow-up study in taiwan

Ping-Song Chou, Wei-Po Chou, Ming-Chao Chen, Chiou-Lian Lai, Yu-Ching Wen, Kun-Chieh Yeh, Wei Pin Chang, Yii-Her Chou

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Introduction: Depression might increase the risk of erectile dysfunction (ED), and ED might further exacerbate depression. The causal relationship between these two diseases remains controversial. In addition, limited evidence is available regarding the age-dependent and time-dependent effects on the association of depression and ED. Aim: We investigated the hypothesis that ED increases the risk of depression by using a nationwide Taiwanese population-based claims database. In addition, we assessed the age-dependent and time-dependent effects on the association of depression and ED. Methods: A longitudinal cohort study was conducted to determine the association between patients with ED and depression development during a 5-year follow-up period, using claims data from the Taiwanese National Health Insurance Research Database. Main Outcome Measures: The study cohort comprised patients who were diagnosed with ED during 1997 to 2005 (N=2,527). For a comparison cohort, 5 age- and sex-matched patients for every patient in the study cohort were selected using random sampling (N=12,635). All of the patients were followed-up for 5 years from the date of cohort entry to identify the development of depression. Results: The main finding of this study was that patients with ED are at an increased risk of developing depression. The adjusted hazard ratio (AHR) for depression was 2.24-fold higher in the patients with ED than in the comparison cohort (95% confidence interval [CI]: 1.83-2.74; P
Original languageEnglish
Pages (from-to)804-812
Number of pages9
JournalJournal of Sexual Medicine
Volume12
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Depression
  • Erectile dysfunction
  • Population-based study
  • Taiwan national health insurance research database
  • Taiwan population
  • adult
  • aged
  • Article
  • cohort analysis
  • comparative study
  • depression
  • diabetes mellitus
  • erectile dysfunction
  • follow up
  • human
  • hyperlipidemia
  • hypertension
  • ICD-9-CM
  • major clinical study
  • male
  • middle aged
  • national health insurance
  • priority journal
  • Taiwanese
  • urbanization
  • Cardiovascular Diseases
  • comorbidity
  • health survey
  • incidence
  • longitudinal study
  • metabolic syndrome X
  • pathophysiology
  • psychology
  • risk factor
  • Taiwan
  • antidepressant agent
  • Adult
  • Aged
  • Antidepressive Agents
  • Cohort Studies
  • Comorbidity
  • Erectile Dysfunction
  • Follow-Up Studies
  • Humans
  • Hypertension
  • Incidence
  • Longitudinal Studies
  • Male
  • Metabolic Syndrome X
  • Middle Aged
  • Population Surveillance
  • Risk Factors

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