New use for old drugs: The protective effect of risperidone on colorectal cancer

Vincent Chin Hung Chen, Yi Hsuan Hsieh, Tzu Chin Lin, Mong Liang Lu, Yin To Liao, Yao Hsu Yang, Tsai Ching Hsu, Robert Stewart, Jun Cheng Weng, Min Jing Lee, Wei Che Chiu, Bor Show Tzang

Research output: Contribution to journalArticle

Abstract

Background: The potential of old drugs in novel indications is being greatly valued. We propose a triple-model study involving population-based, cell, and animal studies to investigate the effects of risperidone, a type of second-generation antipsychotic (SGA) drug, on colorectal cancer. Methods: We used data from Taiwan’s National Health Insurance Research Database between 1997 and 2013 to compare 101,989 patients with colorectal cancer and 101,989 controls. Conditional logistic regression analyses were used to explore the association between SGA exposure and the risk of colorectal cancer. The following bench studies were performed to evaluate the findings of the population-based study. Results: We found that SGAs had been less commonly used in colorectal cancer patients than in controls. The colorectal cancer risk was reduced with an increase in the cumulative defined daily dose (cDDD) of SGAs. The adjusted odds ratio of antipsychotic use for cDDD days was 0.32 (95% CI: 0.25–0.42). Risperidone exhibited the most prominent tumor inhibition effect in a cell screen study. Bench data revealed that risperidone significantly induced apoptosis and elevated intracellular ROS in human SW480 cells and suppressed the proliferation of the xenografted SW480 tumor in nude mice. Conclusion: This triple-model study demonstrates the association between risperidone usage and a lower risk of colorectal cancer.

Original languageEnglish
Article number1560
Pages (from-to)1-16
Number of pages16
JournalCancers
Volume12
Issue number6
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Antipsychotics
  • Colorectal cancer
  • Risperidone
  • SW480
  • Taiwan National Health Insurance

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Chen, V. C. H., Hsieh, Y. H., Lin, T. C., Lu, M. L., Liao, Y. T., Yang, Y. H., Hsu, T. C., Stewart, R., Weng, J. C., Lee, M. J., Chiu, W. C., & Tzang, B. S. (2020). New use for old drugs: The protective effect of risperidone on colorectal cancer. Cancers, 12(6), 1-16. [1560]. https://doi.org/10.3390/cancers12061560