New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum

Safwan Safwan, Shih Wei Wang, George Hsiao, Sui Wen Hsiao, Su Jung Hsu, Tzong Huei Lee, Ching Kuo Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Eight trichothecenes, including four new compounds 1–4 and four known entities 5–8, together with one known cyclonerane (9) were isolated from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. The structures of 1–9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against all three cancer cell lines with the IC50 values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 µM, respectively. Compounds 1–2, 4–6, and 7–8 potently inhibited LPS-induced NO production, and compounds 5 and 8 showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes.

Original languageEnglish
Article number80
JournalMarine Drugs
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 2022

Keywords

  • Cytotoxic activities
  • Endophytic fungus
  • Marine alga
  • Trichoderma brevicompactum
  • Trichothecenes

ASJC Scopus subject areas

  • Drug Discovery

Fingerprint

Dive into the research topics of 'New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum'. Together they form a unique fingerprint.

Cite this