A diagnosis of new-onset diabetes after transplantation (NODAT) is a common complication after kidney transplantation. Most importantly, NODAT affects graft and patient survival, and increases the incidence of post-transplant cardiovascular disease. In this review paper, non-modifiable and modifiable risk factors for NODAT are discussed. In addition, pre-transplant evaluation and post-transplant monitoring of glucose and management of immunosuppression are discussed. If early detection of risk factor for new-onset diabetes, the timely prevention and clinical management, reduce complications, it will help to improve the long-term survival after kidney transplantation.