New markers in pneumonia

Chao Wen Cheng, Ming Hsien Chien, Shih Chi Su, Shun Fa Yang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Pneumonia is one of the most common causes of death from infectious diseases worldwide, and the most common fatal infection acquired in hospitals. Despite advances in prevention strategies, such as antibiotic therapies and intensive care, significant improvement in the mortality rate is still lacking. This high mortality is largely due to the limitations in current clinical practices and laboratory tests, which delay the timing of adequate antibiotic therapy. In recent years, many indicators (biomarkers) are present in scenarios where infectious pathogens invade into the body. These biomarkers, as reflected in specific biological responses to infections, have been reported to demonstrate the ability to facilitate the diagnosis, risk stratification, and management of pneumonia. This review provides a schematic overview of these new potential biomarkers based on the categories of (1) microorganisms and their derivatives, (2) inflammation mediators, (3) inflammation response proteins, and (4) stress-sensing proteins. In addition, approaches to identifying new biomarkers are also briefly introduced. Although no current biomarker can solely achieve a definitive diagnosis, many of them can be complemented, rather than replaced outright, in routine clinical practices to improve decision-making processes regarding pneumonia.

Original languageEnglish
Pages (from-to)19-25
Number of pages7
JournalClinica Chimica Acta
Volume419
DOIs
Publication statusPublished - Apr 8 2013

Fingerprint

Biomarkers
Pneumonia
Inflammation Mediators
Anti-Bacterial Agents
Aptitude
Mortality
Risk Management
Schematic diagrams
Pathogens
Critical Care
Heat-Shock Proteins
Infection
Microorganisms
Communicable Diseases
Cause of Death
Decision Making
Proteins
Decision making
Derivatives
Therapeutics

Keywords

  • Biomarkers
  • Inflammation response proteins
  • Pneumonia

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

New markers in pneumonia. / Cheng, Chao Wen; Chien, Ming Hsien; Su, Shih Chi; Yang, Shun Fa.

In: Clinica Chimica Acta, Vol. 419, 08.04.2013, p. 19-25.

Research output: Contribution to journalArticle

Cheng, Chao Wen ; Chien, Ming Hsien ; Su, Shih Chi ; Yang, Shun Fa. / New markers in pneumonia. In: Clinica Chimica Acta. 2013 ; Vol. 419. pp. 19-25.
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