New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives

Kwang Poo Chang, Bala K. Kolli, Ramesh B. Batchu, Hui Wen Chen, Larry Ming C Chow, Robert Elliott, Jonathan F. Head, Chia Kwung Fan, Chen Hsiung Hung, Dar Der Ji, Zhao Rong Lun, Laura Manna, Yoshitsugu Matsumoto, Dennis K P Ng, Camila I. De Oliveira, Sayonara Melo, Yusuf Ozbel, Ahmet Özbilgin, Joseph Reynolds, Chizu Sanjoba & 9 others Shin Hong Shiao, Nang Yao Shih, Chi Wei Tsai, Maria Da Graça H Vicente, Charles H. Barré, Petr Volf, Yueh Lung Wu, Chao Lan Yu, Xiao Nong Zhou

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Light is known to excite photosensitizers (PS) to produce cytotoxic reactive oxygen species (ROS) in the presence of oxygen. This modality is attractive for designing control measures against animal diseases and pests. Many PS have a proven safety record. Also, the ROS cytotoxicity selects no resistant mutants, unlike other drugs and pesticides. Photodynamic therapy (PDT) refers to the use of PS as light activable tumoricides, microbicides and pesticides in medicine and agriculture. Here we describe "photodynamic vaccination" (PDV) that uses PDT-inactivation of parasites, i.e. Leishmania as whole-cell vaccines against leishmaniasis, and as a universal carrier to deliver transgenic add-on vaccines against other infectious and malignant diseases. The efficacy of Leishmania for vaccine delivery makes use of their inherent attributes to parasitize antigen (vaccine)-presenting cells. Inactivation of Leishmania by PDT provides safety for their use. This is accomplished in two different ways: (i) chemical engineering of PS to enhance their uptake, e.g. Si-phthalocyanines; and (ii) transgenic approach to render Leishmania inducible for porphyrinogenesis. Three different schemes of Leishmania-based PDV are presented diagrammatically to depict the cellular events resulting in cell-mediated immunity, as seen experimentally against leishmaniasis and Leishmania-delivered antigen in vitro and in vivo. Safety versus efficacy evaluations are under way for PDT-inactivated Leishmania, including those further processed to facilitate their storage and transport. Leishmania transfected to express cancer and viral vaccine candidates are being prepared accordingly for experimental trials. We have begun to examine PS-mediated photodynamic insecticides (PDI). Mosquito cells take up rose bengal/cyanosine, rendering them light-sensitive to undergo disintegration in vitro, thereby providing a cellular basis for the larvicidal activity seen by the same treatments. Ineffectiveness of phthalocyanines and porphyrins for PDI underscores its requirement for different PS. Differential uptake of PS by insect versus other cells to account for this difference is under study. The ongoing work is patterned after the one-world approach by enlisting the participation of experts in medicinal chemistry, cell/molecular biology, immunology, parasitology, entomology, cancer research, tropical medicine and veterinary medicine. The availability of multidisciplinary expertise is indispensable for implementation of the necessary studies to move the project toward product development.

Original languageEnglish
Article number396
JournalParasites and Vectors
Volume9
Issue number1
DOIs
Publication statusPublished - Jul 13 2016
Externally publishedYes

Fingerprint

Insect Vectors
Disease Vectors
Animal Diseases
Photosensitizing Agents
Leishmania
Photochemotherapy
Leishmaniasis Vaccines
Insecticides
Safety
Light
Pesticides
Reactive Oxygen Species
Vaccination
Vaccines
Entomology
Viral Vaccines
Chemical Engineering
Tropical Medicine
Rose Bengal
Parasitology

Keywords

  • Leishmania
  • Mosquito
  • Photodynamic insecticide
  • Photodynamic therapy
  • Photodynamic vaccination
  • Photosensitizers

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. / Chang, Kwang Poo; Kolli, Bala K.; Batchu, Ramesh B.; Chen, Hui Wen; Chow, Larry Ming C; Elliott, Robert; Head, Jonathan F.; Fan, Chia Kwung; Hung, Chen Hsiung; Ji, Dar Der; Lun, Zhao Rong; Manna, Laura; Matsumoto, Yoshitsugu; Ng, Dennis K P; De Oliveira, Camila I.; Melo, Sayonara; Ozbel, Yusuf; Özbilgin, Ahmet; Reynolds, Joseph; Sanjoba, Chizu; Shiao, Shin Hong; Shih, Nang Yao; Tsai, Chi Wei; Vicente, Maria Da Graça H; Barré, Charles H.; Volf, Petr; Wu, Yueh Lung; Yu, Chao Lan; Zhou, Xiao Nong.

In: Parasites and Vectors, Vol. 9, No. 1, 396, 13.07.2016.

Research output: Contribution to journalReview article

Chang, KP, Kolli, BK, Batchu, RB, Chen, HW, Chow, LMC, Elliott, R, Head, JF, Fan, CK, Hung, CH, Ji, DD, Lun, ZR, Manna, L, Matsumoto, Y, Ng, DKP, De Oliveira, CI, Melo, S, Ozbel, Y, Özbilgin, A, Reynolds, J, Sanjoba, C, Shiao, SH, Shih, NY, Tsai, CW, Vicente, MDGH, Barré, CH, Volf, P, Wu, YL, Yu, CL & Zhou, XN 2016, 'New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives', Parasites and Vectors, vol. 9, no. 1, 396. https://doi.org/10.1186/s13071-016-1674-3
Chang, Kwang Poo ; Kolli, Bala K. ; Batchu, Ramesh B. ; Chen, Hui Wen ; Chow, Larry Ming C ; Elliott, Robert ; Head, Jonathan F. ; Fan, Chia Kwung ; Hung, Chen Hsiung ; Ji, Dar Der ; Lun, Zhao Rong ; Manna, Laura ; Matsumoto, Yoshitsugu ; Ng, Dennis K P ; De Oliveira, Camila I. ; Melo, Sayonara ; Ozbel, Yusuf ; Özbilgin, Ahmet ; Reynolds, Joseph ; Sanjoba, Chizu ; Shiao, Shin Hong ; Shih, Nang Yao ; Tsai, Chi Wei ; Vicente, Maria Da Graça H ; Barré, Charles H. ; Volf, Petr ; Wu, Yueh Lung ; Yu, Chao Lan ; Zhou, Xiao Nong. / New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. In: Parasites and Vectors. 2016 ; Vol. 9, No. 1.
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AU - Chang, Kwang Poo

AU - Kolli, Bala K.

AU - Batchu, Ramesh B.

AU - Chen, Hui Wen

AU - Chow, Larry Ming C

AU - Elliott, Robert

AU - Head, Jonathan F.

AU - Fan, Chia Kwung

AU - Hung, Chen Hsiung

AU - Ji, Dar Der

AU - Lun, Zhao Rong

AU - Manna, Laura

AU - Matsumoto, Yoshitsugu

AU - Ng, Dennis K P

AU - De Oliveira, Camila I.

AU - Melo, Sayonara

AU - Ozbel, Yusuf

AU - Özbilgin, Ahmet

AU - Reynolds, Joseph

AU - Sanjoba, Chizu

AU - Shiao, Shin Hong

AU - Shih, Nang Yao

AU - Tsai, Chi Wei

AU - Vicente, Maria Da Graça H

AU - Barré, Charles H.

AU - Volf, Petr

AU - Wu, Yueh Lung

AU - Yu, Chao Lan

AU - Zhou, Xiao Nong

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KW - Mosquito

KW - Photodynamic insecticide

KW - Photodynamic therapy

KW - Photodynamic vaccination

KW - Photosensitizers

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