New isoflavones and anti-inflammatory constituents from the fruits of Cnidium monnieri

Zong-Huei Li, Yuan Chih Chen, Tsong Long Hwang, Chih Wen Shu, Ping Jyun Sung, Yun Ping Lim, Wen Lung Kuo, Jih Jung Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The fruit of Cnidium monnieri is commercially used as healthcare products for the improvement of impotence and skin diseases. Three new coumarins, 3'-O-methylmurraol (1), rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2), and (1'S,2'S)-1'-O-methylvaginol (3), have been isolated from the fruits of C. monnieri, together with 14 known compounds (4-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4-12, and 14-17 exhibited inhibition (IC50 ≤ 7.31 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 7, 9-11, 15, and 17 inhibited fMLP/CB-induced elastase release with IC50 values ≤7.83 μg/mL. This investigation reveals that bioactive isolates (especially 6, 7, 14, and 17) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.

Original languageEnglish
Pages (from-to)9566-9578
Number of pages13
JournalInternational Journal of Molecular Sciences
Volume15
Issue number6
DOIs
Publication statusPublished - Mar 28 2014

Fingerprint

leucyl-phenylalanine
Cnidium
Cytochalasin B
Isoflavones
phenylalanine
fruits
Fruits
Phenylalanine
Inhibitory Concentration 50
Fruit
Anti-Inflammatory Agents
neutrophils
Coumarins
inorganic peroxides
Pancreatic Elastase
Erectile Dysfunction
activity (biology)
Skin Diseases
Superoxides
Skin

Keywords

  • Anti-inflammatory activity
  • Cnidium monnieri
  • Isoflavones
  • Structure elucidation
  • Umbelliferae

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Medicine(all)

Cite this

Li, Z-H., Chen, Y. C., Hwang, T. L., Shu, C. W., Sung, P. J., Lim, Y. P., ... Chen, J. J. (2014). New isoflavones and anti-inflammatory constituents from the fruits of Cnidium monnieri. International Journal of Molecular Sciences, 15(6), 9566-9578. https://doi.org/10.3390/ijms15069566

New isoflavones and anti-inflammatory constituents from the fruits of Cnidium monnieri. / Li, Zong-Huei; Chen, Yuan Chih; Hwang, Tsong Long; Shu, Chih Wen; Sung, Ping Jyun; Lim, Yun Ping; Kuo, Wen Lung; Chen, Jih Jung.

In: International Journal of Molecular Sciences, Vol. 15, No. 6, 28.03.2014, p. 9566-9578.

Research output: Contribution to journalArticle

Li, Z-H, Chen, YC, Hwang, TL, Shu, CW, Sung, PJ, Lim, YP, Kuo, WL & Chen, JJ 2014, 'New isoflavones and anti-inflammatory constituents from the fruits of Cnidium monnieri', International Journal of Molecular Sciences, vol. 15, no. 6, pp. 9566-9578. https://doi.org/10.3390/ijms15069566
Li, Zong-Huei ; Chen, Yuan Chih ; Hwang, Tsong Long ; Shu, Chih Wen ; Sung, Ping Jyun ; Lim, Yun Ping ; Kuo, Wen Lung ; Chen, Jih Jung. / New isoflavones and anti-inflammatory constituents from the fruits of Cnidium monnieri. In: International Journal of Molecular Sciences. 2014 ; Vol. 15, No. 6. pp. 9566-9578.
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