New isoflavones and anti-inflammatory constituents from the fruits of Cnidium monnieri

Zong-Huei Li, Yuan Chih Chen, Tsong Long Hwang, Chih Wen Shu, Ping Jyun Sung, Yun Ping Lim, Wen Lung Kuo, Jih Jung Chen

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The fruit of Cnidium monnieri is commercially used as healthcare products for the improvement of impotence and skin diseases. Three new coumarins, 3'-O-methylmurraol (1), rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2), and (1'S,2'S)-1'-O-methylvaginol (3), have been isolated from the fruits of C. monnieri, together with 14 known compounds (4-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4-12, and 14-17 exhibited inhibition (IC50 ≤ 7.31 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 7, 9-11, 15, and 17 inhibited fMLP/CB-induced elastase release with IC50 values ≤7.83 μg/mL. This investigation reveals that bioactive isolates (especially 6, 7, 14, and 17) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.

Original languageEnglish
Pages (from-to)9566-9578
Number of pages13
JournalInternational Journal of Molecular Sciences
Volume15
Issue number6
DOIs
Publication statusPublished - Mar 28 2014

Keywords

  • Anti-inflammatory activity
  • Cnidium monnieri
  • Isoflavones
  • Structure elucidation
  • Umbelliferae

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Medicine(all)

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