New cytotoxic briaran diterpenes from the formosan gorgonian Briareum sp.

Jyh Horng Sheu, Ping Jyun Sung, Li Huei Huang, Shu Fang Lee, Tzuhua Wu, Bih Yuan Chang, Chang Yih Duh, Lee Shing Fang, Keryea Soong, Tsong Jen Lee

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Abstract

Three new briaran diterpenes, 2β-acetoxy-2-(debutyryloxy)stecholide E (3), 9-deacetylstylatulide lactone (4), and 4β-acetoxy-9-deacetylstylatulide lactone (5), and two known diterpenes, brianthein W (1) and 9- deacetylbriareolide H (2), have been isolated from a Briareum sp. of gorgonian. The structures and relative stereochemistry of these compounds were determined by spectroscopic and chemical methods. Diterpenes 2-4 and the corresponding 9-acetyl derivatives 6, 7, and 12 exhibited cytotoxicity toward various cancer cell lines.

Original languageEnglish
Pages (from-to)935-938
Number of pages4
JournalJournal of Natural Products
Volume59
Issue number10
DOIs
Publication statusPublished - Oct 1 1996

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ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Sheu, J. H., Sung, P. J., Huang, L. H., Lee, S. F., Wu, T., Chang, B. Y., Duh, C. Y., Fang, L. S., Soong, K., & Lee, T. J. (1996). New cytotoxic briaran diterpenes from the formosan gorgonian Briareum sp. Journal of Natural Products, 59(10), 935-938. https://doi.org/10.1021/np960218s