New application of heparin-bonded extracorporeal membrane oxygenation in difficult neurosurgery

Yih Sharng Chen, Wen Je Ko, Fang Yue Lin, Shu Chien Huang, Shoei Shen Wang, Yong Kwang Tu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We wished to evaluate the safety and the advantages of using heparin-bonded extracorporeal membrane oxygenation (ECMO) to replace conventional cardiopulmonary bypass (CPB) in deep hypothermic circulation for complex cerebral aneurysm surgery. Heparin-bonded ECMO without the bridging tube and the cardiotomy reservoir was set up through the femoral vessels. Limited heparin was infused. In deep hypothermia, the ECMO blood flow was temporarily decreased as low as the neurosurgeons' request. It was applied to 4 patients with difficult intracranial aneurysms who were selected for the procedure. Clipping, wrapping, or vascular bypass was implemented to manage the aneurysms under deep hypothermia. The total heparin dosage used in the whole procedure was 9,875 ± 1,625 U, and the mean ECMO time was 270 ± 105 min. The blood consumption was packed red blood cell 3.0 ± 0.5 U and fresh frozen plasma 3.8 ± 2.3 U. Compared with our previous experiences using conventional CPB, ECMO did need less heparin and blood transfusions. Clipping was applied in 2 patients, wrapping in 1, and venous graft interposition was performed in 1. Mortality occurred in 1 patient (25%) due to brain herniation. This preliminary study suggested that the heparin-bonded ECMO without reservoir in deep hypothermia could be safe in cerebral aneurysm surgery under a low flow circuit.

Original languageEnglish
Pages (from-to)627-632
Number of pages6
JournalArtificial Organs
Volume25
Issue number8
DOIs
Publication statusPublished - Sep 17 2001
Externally publishedYes

Fingerprint

Neurosurgery
Extracorporeal Membrane Oxygenation
Oxygenation
Heparin
Hypothermia
Membranes
Intracranial Aneurysm
Blood
Cardiopulmonary Bypass
Surgery
Thigh
Grafts
Blood Transfusion
Aneurysm
Blood Vessels
Brain
Erythrocytes
Cells
Transplants
Plasmas

Keywords

  • Cardiopulmonary bypass
  • Cerebral aneurysm
  • Extracorporeal membrane oxygenation

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

New application of heparin-bonded extracorporeal membrane oxygenation in difficult neurosurgery. / Chen, Yih Sharng; Ko, Wen Je; Lin, Fang Yue; Huang, Shu Chien; Wang, Shoei Shen; Tu, Yong Kwang.

In: Artificial Organs, Vol. 25, No. 8, 17.09.2001, p. 627-632.

Research output: Contribution to journalArticle

Chen, Yih Sharng ; Ko, Wen Je ; Lin, Fang Yue ; Huang, Shu Chien ; Wang, Shoei Shen ; Tu, Yong Kwang. / New application of heparin-bonded extracorporeal membrane oxygenation in difficult neurosurgery. In: Artificial Organs. 2001 ; Vol. 25, No. 8. pp. 627-632.
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