New abietane-type diterpenoids from the bark of cryptomeria japonica

Chi I. Chang, Jih Jung Chen, Chin Hsu, Cheng Chi Chen, Wei Yi Cheng, Sheng Yang Wang, Ching Kuo Lee, Ming Jen Cheng, Yueh Hsiung Kuo

Research output: Contribution to journalArticle

Abstract

Two new abietane-type diterpenoids, 15-hydroxy-12-O-methylsugiol (1) and 2?-hydroxy-12-O-methylsugiol (2) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. Compounds 2 showed 13.5% inhibition towards xanthine oxidase enzyme at the concentration of 75 μM.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalNatural Product Communications
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Abietane
  • Cryptomeria japonica
  • Cupressaceae
  • Diterpenoid
  • Traditional herbal medicine

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

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  • Cite this

    Chang, C. I., Chen, J. J., Hsu, C., Chen, C. C., Cheng, W. Y., Wang, S. Y., Lee, C. K., Cheng, M. J., & Kuo, Y. H. (2019). New abietane-type diterpenoids from the bark of cryptomeria japonica. Natural Product Communications, 14(1), 97-100. https://doi.org/10.1177/1934578X1901400125