Neuropsychological functions and quality of life in survived patients with intracranial germ cell tumors after treatment

Shih Yuan Liang, Tsui Fen Yang, Yi Wei Chen, Muh Lii Liang, Hsin Hung Chen, Kai Ping Chang, Ian Kai Shan, Ying Sheue Chen, Tai-Tong Wong

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background. The notable survival chances of intracranial germ cell tumors (icGCTs) lead to a rising concern over long-term neurocognitive outcome. Yet, prior evidence related to this issue fails to provide a comprehensive examination of the effects of tumor location and radiotherapy. We attempt to explore their impacts on the neuropsychological functions and life quality in children with icGCT after multimodality treatments. Methods. Aretrospective reviewof 56 patients diagnosed with icGCTs at age,20 and treated at theTaipeiVeterans General Hospital was provided. Intelligence, memory, visual organization, attention, and executive function were assessed by neurocognitive tests; adaptation to life, emotional and behavioral changes, interpersonal relationships, and impact on the family were evaluated by parentreport instruments. Effects of tumor locations (germinomas and nongerminomatous malignant germ cell tumors in the pineal, suprasellar, and basal ganglia) and irradiation on these measurements were examined. Results. Patients with tumors in the basal ganglia region had lower full-scale IQs than those with tumors in the pineal or suprasellar regions. Subscores of intelligence scale and short-term retention of verbal and visual stimuli showed evident group differences, as did the quality oflife and adaptive skills, particularly in psychosocial domains. Patients treated with whole-ventricular irradiation had better outcomes. Extensive irradiation field and high irradiation dosage influenced intellectual functions, concept crystallization, executive function, and memory. Conclusions. Tumor location and irradiation field/dosage appear to be the crucial factors related to certain neuropsychological, emotional, and behavioral dysfunctions that in turn alter the quality of life in children with icGCTs who survive after treatment.

Original languageEnglish
Pages (from-to)1543-1551
Number of pages9
JournalNeuro-Oncology
Volume15
Issue number11
DOIs
Publication statusPublished - Dec 1 2013
Externally publishedYes

Fingerprint

Germ Cell and Embryonal Neoplasms
Quality of Life
Executive Function
Basal Ganglia
Intelligence
Neoplasms
Germinoma
Pinealoma
Therapeutics
Crystallization
General Hospitals
Radiotherapy
Organizations
Survival

Keywords

  • Basal ganglia
  • Intracranial germ cell tumors
  • Neurocognitive functions
  • Quality of life
  • Whole ventricular irradiation

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology
  • Cancer Research

Cite this

Neuropsychological functions and quality of life in survived patients with intracranial germ cell tumors after treatment. / Liang, Shih Yuan; Yang, Tsui Fen; Chen, Yi Wei; Liang, Muh Lii; Chen, Hsin Hung; Chang, Kai Ping; Shan, Ian Kai; Chen, Ying Sheue; Wong, Tai-Tong.

In: Neuro-Oncology, Vol. 15, No. 11, 01.12.2013, p. 1543-1551.

Research output: Contribution to journalArticle

Liang, SY, Yang, TF, Chen, YW, Liang, ML, Chen, HH, Chang, KP, Shan, IK, Chen, YS & Wong, T-T 2013, 'Neuropsychological functions and quality of life in survived patients with intracranial germ cell tumors after treatment', Neuro-Oncology, vol. 15, no. 11, pp. 1543-1551. https://doi.org/10.1093/neuonc/not127
Liang, Shih Yuan ; Yang, Tsui Fen ; Chen, Yi Wei ; Liang, Muh Lii ; Chen, Hsin Hung ; Chang, Kai Ping ; Shan, Ian Kai ; Chen, Ying Sheue ; Wong, Tai-Tong. / Neuropsychological functions and quality of life in survived patients with intracranial germ cell tumors after treatment. In: Neuro-Oncology. 2013 ; Vol. 15, No. 11. pp. 1543-1551.
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abstract = "Background. The notable survival chances of intracranial germ cell tumors (icGCTs) lead to a rising concern over long-term neurocognitive outcome. Yet, prior evidence related to this issue fails to provide a comprehensive examination of the effects of tumor location and radiotherapy. We attempt to explore their impacts on the neuropsychological functions and life quality in children with icGCT after multimodality treatments. Methods. Aretrospective reviewof 56 patients diagnosed with icGCTs at age,20 and treated at theTaipeiVeterans General Hospital was provided. Intelligence, memory, visual organization, attention, and executive function were assessed by neurocognitive tests; adaptation to life, emotional and behavioral changes, interpersonal relationships, and impact on the family were evaluated by parentreport instruments. Effects of tumor locations (germinomas and nongerminomatous malignant germ cell tumors in the pineal, suprasellar, and basal ganglia) and irradiation on these measurements were examined. Results. Patients with tumors in the basal ganglia region had lower full-scale IQs than those with tumors in the pineal or suprasellar regions. Subscores of intelligence scale and short-term retention of verbal and visual stimuli showed evident group differences, as did the quality oflife and adaptive skills, particularly in psychosocial domains. Patients treated with whole-ventricular irradiation had better outcomes. Extensive irradiation field and high irradiation dosage influenced intellectual functions, concept crystallization, executive function, and memory. Conclusions. Tumor location and irradiation field/dosage appear to be the crucial factors related to certain neuropsychological, emotional, and behavioral dysfunctions that in turn alter the quality of life in children with icGCTs who survive after treatment.",
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AU - Yang, Tsui Fen

AU - Chen, Yi Wei

AU - Liang, Muh Lii

AU - Chen, Hsin Hung

AU - Chang, Kai Ping

AU - Shan, Ian Kai

AU - Chen, Ying Sheue

AU - Wong, Tai-Tong

PY - 2013/12/1

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N2 - Background. The notable survival chances of intracranial germ cell tumors (icGCTs) lead to a rising concern over long-term neurocognitive outcome. Yet, prior evidence related to this issue fails to provide a comprehensive examination of the effects of tumor location and radiotherapy. We attempt to explore their impacts on the neuropsychological functions and life quality in children with icGCT after multimodality treatments. Methods. Aretrospective reviewof 56 patients diagnosed with icGCTs at age,20 and treated at theTaipeiVeterans General Hospital was provided. Intelligence, memory, visual organization, attention, and executive function were assessed by neurocognitive tests; adaptation to life, emotional and behavioral changes, interpersonal relationships, and impact on the family were evaluated by parentreport instruments. Effects of tumor locations (germinomas and nongerminomatous malignant germ cell tumors in the pineal, suprasellar, and basal ganglia) and irradiation on these measurements were examined. Results. Patients with tumors in the basal ganglia region had lower full-scale IQs than those with tumors in the pineal or suprasellar regions. Subscores of intelligence scale and short-term retention of verbal and visual stimuli showed evident group differences, as did the quality oflife and adaptive skills, particularly in psychosocial domains. Patients treated with whole-ventricular irradiation had better outcomes. Extensive irradiation field and high irradiation dosage influenced intellectual functions, concept crystallization, executive function, and memory. Conclusions. Tumor location and irradiation field/dosage appear to be the crucial factors related to certain neuropsychological, emotional, and behavioral dysfunctions that in turn alter the quality of life in children with icGCTs who survive after treatment.

AB - Background. The notable survival chances of intracranial germ cell tumors (icGCTs) lead to a rising concern over long-term neurocognitive outcome. Yet, prior evidence related to this issue fails to provide a comprehensive examination of the effects of tumor location and radiotherapy. We attempt to explore their impacts on the neuropsychological functions and life quality in children with icGCT after multimodality treatments. Methods. Aretrospective reviewof 56 patients diagnosed with icGCTs at age,20 and treated at theTaipeiVeterans General Hospital was provided. Intelligence, memory, visual organization, attention, and executive function were assessed by neurocognitive tests; adaptation to life, emotional and behavioral changes, interpersonal relationships, and impact on the family were evaluated by parentreport instruments. Effects of tumor locations (germinomas and nongerminomatous malignant germ cell tumors in the pineal, suprasellar, and basal ganglia) and irradiation on these measurements were examined. Results. Patients with tumors in the basal ganglia region had lower full-scale IQs than those with tumors in the pineal or suprasellar regions. Subscores of intelligence scale and short-term retention of verbal and visual stimuli showed evident group differences, as did the quality oflife and adaptive skills, particularly in psychosocial domains. Patients treated with whole-ventricular irradiation had better outcomes. Extensive irradiation field and high irradiation dosage influenced intellectual functions, concept crystallization, executive function, and memory. Conclusions. Tumor location and irradiation field/dosage appear to be the crucial factors related to certain neuropsychological, emotional, and behavioral dysfunctions that in turn alter the quality of life in children with icGCTs who survive after treatment.

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KW - Quality of life

KW - Whole ventricular irradiation

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