Neuropsychiatric symptoms in Alzheimer's disease are related to functional connectivity alterations in the salience network

Marcio L F Balthazar, Fabrício R S Pereira, Tátila M. Lopes, Elvis L. da Silva, Ana Carolina Coan, Brunno M. Campos, Niall W. Duncan, Florindo Stella, Georg Northoff, Benito P. Damasceno, Fernando Cendes

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Neuropsychiatric syndromes are highly prevalent in Alzheimer's disease (AD), but their neurobiology is not completely understood. New methods in functional magnetic resonance imaging, such as intrinsic functional connectivity or "resting-state" analysis, may help to clarify this issue. Using such approaches, alterations in the default-mode and salience networks (SNs) have been described in Alzheimer's, although their relationship with specific symptoms remains unclear. We therefore carried out resting-state functional connectivity analysis with 20 patients with mild to moderate AD, and correlated their scores on neuropsychiatric inventory syndromes (apathy, hyperactivity, affective syndrome, and psychosis) with maps of connectivity in the default mode network and SN. In addition, we compared network connectivity in these patients with that in 17 healthy elderly control subjects. All analyses were controlled for gray matter density and other potential confounds. Alzheimer's patients showed increased functional connectivity within the SN compared with controls (right anterior cingulate cortex and left medial frontal gyrus), along with reduced functional connectivity in the default-mode network (bilateral precuneus). A correlation between increased connectivity in anterior cingulate cortex and right insula areas of the SN and hyperactivity syndrome (agitation, irritability, aberrant motor behavior, euphoria, and disinhibition) was found. These findings demonstrate an association between specific network changes in AD and particular neuropsychiatric symptom types. This underlines the potential clinical significance of resting state alterations in future diagnosis and therapy.

Original languageEnglish
Pages (from-to)1237-1246
Number of pages10
JournalHuman Brain Mapping
Volume35
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Alzheimer Disease
Gyrus Cinguli
Psychotic Affective Disorders
Apathy
Parietal Lobe
Neurobiology
Prefrontal Cortex
Magnetic Resonance Imaging
Equipment and Supplies
Therapeutics

Keywords

  • Alzheimer's disease
  • Default mode network
  • Functional connectivity
  • Neuropsychiatric symptoms
  • Salience network

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Medicine(all)

Cite this

Balthazar, M. L. F., Pereira, F. R. S., Lopes, T. M., da Silva, E. L., Coan, A. C., Campos, B. M., ... Cendes, F. (2014). Neuropsychiatric symptoms in Alzheimer's disease are related to functional connectivity alterations in the salience network. Human Brain Mapping, 35(4), 1237-1246. https://doi.org/10.1002/hbm.22248

Neuropsychiatric symptoms in Alzheimer's disease are related to functional connectivity alterations in the salience network. / Balthazar, Marcio L F; Pereira, Fabrício R S; Lopes, Tátila M.; da Silva, Elvis L.; Coan, Ana Carolina; Campos, Brunno M.; Duncan, Niall W.; Stella, Florindo; Northoff, Georg; Damasceno, Benito P.; Cendes, Fernando.

In: Human Brain Mapping, Vol. 35, No. 4, 2014, p. 1237-1246.

Research output: Contribution to journalArticle

Balthazar, MLF, Pereira, FRS, Lopes, TM, da Silva, EL, Coan, AC, Campos, BM, Duncan, NW, Stella, F, Northoff, G, Damasceno, BP & Cendes, F 2014, 'Neuropsychiatric symptoms in Alzheimer's disease are related to functional connectivity alterations in the salience network', Human Brain Mapping, vol. 35, no. 4, pp. 1237-1246. https://doi.org/10.1002/hbm.22248
Balthazar, Marcio L F ; Pereira, Fabrício R S ; Lopes, Tátila M. ; da Silva, Elvis L. ; Coan, Ana Carolina ; Campos, Brunno M. ; Duncan, Niall W. ; Stella, Florindo ; Northoff, Georg ; Damasceno, Benito P. ; Cendes, Fernando. / Neuropsychiatric symptoms in Alzheimer's disease are related to functional connectivity alterations in the salience network. In: Human Brain Mapping. 2014 ; Vol. 35, No. 4. pp. 1237-1246.
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