Neuroprotective properties of nitric oxide and S-nitrosoglutathione

Pekka Rauhala, Tsugunobu Andoh, Juang-Ching Chiue

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Oxidative stress and apoptosis may play an important role in the neurodegeneration. The present paper outlines antioxidative and antiapototic mechanisms of nitric oxide and S-nitrosothiols, which could mediate neuroprotection. Nitric oxide generated by nitric oxide synthase or released from an endogenous S-nitrosothiol, S-nitrosoglutathione may up-regulate antioxidative thioredoxin system and antiapototic Bcl-2 protein through a cGMP-dependent mechanism. Moreover, nitric oxide radicals have been shown to have direct antioxidant effect through their reaction with free radicals and iron-oxygen complexes. In addition to serving as a stabilizer and carrier of nitric oxide, S-nitrosoglutathione may have protective effect through transnitrosylation reactions. Based on these new findings, a hypothesis arises that the homeostasis of nitric oxide, S-nitrosothiols, glutathione, and thioredoxin systems is important for protection against oxidative stress, apoptosis, and related neurodegenerative disorders.

Original languageEnglish
JournalToxicology and Applied Pharmacology
Volume207
Issue number2 SUPPL.
DOIs
Publication statusPublished - Sep 1 2005

Keywords

  • Apoptosis
  • Bcl-2
  • Dopamine
  • Iron
  • Neuroprotection
  • Preconditioning
  • S-nitrosothiols
  • Thioredoxin

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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