Neuroprotective mechanism of BNG-1 against focal cerebral ischemia: A neuroimaging and neurotrophin study

Nai Fang Chi, Ho Ling Liu, Jen Tsung Yang, Jr Rung Lin, Shu Li Liao, Bo Han Peng, Yen Tung Lee, Tsong Hai Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

BNG-1 is a herb complex used in traditional Chinese medicine to treat stroke. In this study, we attempted to identify the neuroprotective mechanism of BNG-1 by using neuroimaging and neurotrophin analyses of a stroke animal model. Rats were treated with either saline or BNG-1 for 7 d after 60-min middle cerebral artery occlusion by filament model. The temporal change of magnetic resonance (MR) imaging of brain was studied using a 7 Tesla MR imaging (MRI) system and the temporal expressions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in brain were analyzed before operation and at 4 h, 2 d, and 7 d after operation. Compared with the saline group, the BNG-1 group exhibited a smaller infarction volume in the cerebral cortex in T2 image from as early as 4 h to 7 d, less edema in the cortex in diffusion weighted image from 2 to 7 d, earlier reduction of postischemic hyperperfusion in both the cortex and striatum in perfusion image at 4 h, and earlier normalization of the ischemic pattern in the striatum in susceptibility weighted image at 2 d. NT-3 and BDNF levels were higher in the BNG-1 group than the saline group at 7 d. We concluded that the protective effect of BNG-1 against cerebral ischemic injury might act through improving cerebral hemodynamics and recovering neurotrophin generation.

Original languageEnglish
Article numbere114909
JournalPLoS One
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 15 2014

Fingerprint

Neuroimaging
Neurotrophin 3
neurotrophins
Brain-Derived Neurotrophic Factor
Nerve Growth Factors
Magnetic resonance
ischemia
Brain Ischemia
Brain
Stroke
Magnetic Resonance Imaging
Middle Cerebral Artery Infarction
Chinese Traditional Medicine
Hemodynamics
Nerve Growth Factor
Imaging systems
Cerebral Cortex
Infarction
Medicine
brain

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Neuroprotective mechanism of BNG-1 against focal cerebral ischemia : A neuroimaging and neurotrophin study. / Chi, Nai Fang; Liu, Ho Ling; Yang, Jen Tsung; Lin, Jr Rung; Liao, Shu Li; Peng, Bo Han; Lee, Yen Tung; Lee, Tsong Hai.

In: PLoS One, Vol. 9, No. 12, e114909, 15.12.2014.

Research output: Contribution to journalArticle

Chi, Nai Fang ; Liu, Ho Ling ; Yang, Jen Tsung ; Lin, Jr Rung ; Liao, Shu Li ; Peng, Bo Han ; Lee, Yen Tung ; Lee, Tsong Hai. / Neuroprotective mechanism of BNG-1 against focal cerebral ischemia : A neuroimaging and neurotrophin study. In: PLoS One. 2014 ; Vol. 9, No. 12.
@article{31c1061487984d13ae7921f4fefc63d8,
title = "Neuroprotective mechanism of BNG-1 against focal cerebral ischemia: A neuroimaging and neurotrophin study",
abstract = "BNG-1 is a herb complex used in traditional Chinese medicine to treat stroke. In this study, we attempted to identify the neuroprotective mechanism of BNG-1 by using neuroimaging and neurotrophin analyses of a stroke animal model. Rats were treated with either saline or BNG-1 for 7 d after 60-min middle cerebral artery occlusion by filament model. The temporal change of magnetic resonance (MR) imaging of brain was studied using a 7 Tesla MR imaging (MRI) system and the temporal expressions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in brain were analyzed before operation and at 4 h, 2 d, and 7 d after operation. Compared with the saline group, the BNG-1 group exhibited a smaller infarction volume in the cerebral cortex in T2 image from as early as 4 h to 7 d, less edema in the cortex in diffusion weighted image from 2 to 7 d, earlier reduction of postischemic hyperperfusion in both the cortex and striatum in perfusion image at 4 h, and earlier normalization of the ischemic pattern in the striatum in susceptibility weighted image at 2 d. NT-3 and BDNF levels were higher in the BNG-1 group than the saline group at 7 d. We concluded that the protective effect of BNG-1 against cerebral ischemic injury might act through improving cerebral hemodynamics and recovering neurotrophin generation.",
author = "Chi, {Nai Fang} and Liu, {Ho Ling} and Yang, {Jen Tsung} and Lin, {Jr Rung} and Liao, {Shu Li} and Peng, {Bo Han} and Lee, {Yen Tung} and Lee, {Tsong Hai}",
year = "2014",
month = "12",
day = "15",
doi = "10.1371/journal.pone.0114909",
language = "English",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

TY - JOUR

T1 - Neuroprotective mechanism of BNG-1 against focal cerebral ischemia

T2 - A neuroimaging and neurotrophin study

AU - Chi, Nai Fang

AU - Liu, Ho Ling

AU - Yang, Jen Tsung

AU - Lin, Jr Rung

AU - Liao, Shu Li

AU - Peng, Bo Han

AU - Lee, Yen Tung

AU - Lee, Tsong Hai

PY - 2014/12/15

Y1 - 2014/12/15

N2 - BNG-1 is a herb complex used in traditional Chinese medicine to treat stroke. In this study, we attempted to identify the neuroprotective mechanism of BNG-1 by using neuroimaging and neurotrophin analyses of a stroke animal model. Rats were treated with either saline or BNG-1 for 7 d after 60-min middle cerebral artery occlusion by filament model. The temporal change of magnetic resonance (MR) imaging of brain was studied using a 7 Tesla MR imaging (MRI) system and the temporal expressions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in brain were analyzed before operation and at 4 h, 2 d, and 7 d after operation. Compared with the saline group, the BNG-1 group exhibited a smaller infarction volume in the cerebral cortex in T2 image from as early as 4 h to 7 d, less edema in the cortex in diffusion weighted image from 2 to 7 d, earlier reduction of postischemic hyperperfusion in both the cortex and striatum in perfusion image at 4 h, and earlier normalization of the ischemic pattern in the striatum in susceptibility weighted image at 2 d. NT-3 and BDNF levels were higher in the BNG-1 group than the saline group at 7 d. We concluded that the protective effect of BNG-1 against cerebral ischemic injury might act through improving cerebral hemodynamics and recovering neurotrophin generation.

AB - BNG-1 is a herb complex used in traditional Chinese medicine to treat stroke. In this study, we attempted to identify the neuroprotective mechanism of BNG-1 by using neuroimaging and neurotrophin analyses of a stroke animal model. Rats were treated with either saline or BNG-1 for 7 d after 60-min middle cerebral artery occlusion by filament model. The temporal change of magnetic resonance (MR) imaging of brain was studied using a 7 Tesla MR imaging (MRI) system and the temporal expressions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in brain were analyzed before operation and at 4 h, 2 d, and 7 d after operation. Compared with the saline group, the BNG-1 group exhibited a smaller infarction volume in the cerebral cortex in T2 image from as early as 4 h to 7 d, less edema in the cortex in diffusion weighted image from 2 to 7 d, earlier reduction of postischemic hyperperfusion in both the cortex and striatum in perfusion image at 4 h, and earlier normalization of the ischemic pattern in the striatum in susceptibility weighted image at 2 d. NT-3 and BDNF levels were higher in the BNG-1 group than the saline group at 7 d. We concluded that the protective effect of BNG-1 against cerebral ischemic injury might act through improving cerebral hemodynamics and recovering neurotrophin generation.

UR - http://www.scopus.com/inward/record.url?scp=84918504385&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84918504385&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0114909

DO - 10.1371/journal.pone.0114909

M3 - Article

C2 - 25506838

AN - SCOPUS:84918504385

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

M1 - e114909

ER -