Neuroprotective activity of vitis thunbergii var. taiwaniana extracts in vitro and in vivo

Chung Kwe Wang, Lih Geeng Chen, Chi Luan Wen, Wen Chi Hou, Ling Fang Hung, Shish Jung Yen, Yi Jyun Shen, Shyr Yi Lin, Yu Chih Liang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Vitis thunbergii var. taiwaniana (VTT) is a wild grape native to Taiwan, where it has been used as a folk medicine. In this study, we found that the branch and leaf ethanol extracts of VTT significantly inhibited the inducible nitric oxide (NO) synthase protein expression and NO production in BV2 microglia. Using primary neuronal cells, kainic acid (KA) significantly increased hydrogen peroxide production in a dose-dependent manner. All four ethanol extracts of VTT significantly decreased hydrogen peroxide production. However, only root and branch ethanol extracts were able to prevent the neuronal cell death induced by KA in vitro. In the animal study, administration of all four plant part extracts of VTT delayed the onset of seizure and decreased the hippocampus neuronal cell loss, and the neuroprotective activity could be ranked as follows: branch∼leaf> root > trunk. The results suggest that VTT extracts have a potential to prevent neurodegeneration through the antioxidative activity by their ability to inhibit NO and hydrogen peroxide production.

Original languageEnglish
Pages (from-to)170-178
Number of pages9
JournalJournal of Medicinal Food
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 1 2010

Keywords

  • Kainic acid
  • Microglia
  • Neuronal cells
  • Vitis thunbergii var. taiwaniana

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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