Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats

Hsiao-Chi Chuang; Hsin-Chang Chen; Pei-Jui Chai; Ho-Tang Liao; Chang-Fu Wu; Chia-Ling Chen; Ming-Kai Jhan; Hui-I Hsieh; Kuen-Yuh Wu; Ta-Fu Chen; Tsun-Jen Cheng

doi:10.1186/s12989-020-00388-6

Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats

Hsiao-Chi Chuang, Hsin-Chang Chen, Pei-Jui Chai, Ho-Tang Liao, Chang-Fu Wu, Chia-Ling Chen, Ming-Kai Jhan, Hui-I Hsieh, Kuen-Yuh Wu, Ta-Fu Chen, Tsun-Jen Cheng

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM2.5 in spontaneously hypertensive (SH) rats.

Original language	Chinese (Traditional)
Journal	Particle and Fibre Toxicology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12989-020-00388-6
Publication status	Published - 2020

Access to Document

10.1186/s12989-020-00388-6

Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats
Chuang, H. (Contributor), Chen, H. (Contributor), Chai, P. (Contributor), Liao, H. (Contributor), Wu, C. (Contributor), Chen, C. (Contributor), Jhan, M. (Contributor), Hsieh, H. (Contributor), Wu, K. (Contributor), Chen, T. (Contributor) & Cheng, T. (Contributor), Unknown Publisher, Jan 1 2020
DOI: 10.6084/m9.figshare.c.5221075.v1, https://springernature.figshare.com/collections/Neuropathology_changed_by_3-_and_6-months_low-level_PM2_5_inhalation_exposure_in_spontaneously_hypertensive_rats/5221075/1
Dataset

Cite this

Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats. / Chuang, Hsiao-Chi; Chen, Hsin-Chang; Chai, Pei-Jui; Liao, Ho-Tang; Wu, Chang-Fu; Chen, Chia-Ling; Jhan, Ming-Kai; Hsieh, Hui-I; Wu, Kuen-Yuh; Chen, Ta-Fu; Cheng, Tsun-Jen.

In: Particle and Fibre Toxicology, Vol. 17, No. 1, 2020.

Research output: Contribution to journal › Article › peer-review

@article{108fd595bcfd449b9b601fc20cd79590,

title = "Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats",

abstract = "Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM2.5 in spontaneously hypertensive (SH) rats.",

author = "Hsiao-Chi Chuang and Hsin-Chang Chen and Pei-Jui Chai and Ho-Tang Liao and Chang-Fu Wu and Chia-Ling Chen and Ming-Kai Jhan and Hui-I Hsieh and Kuen-Yuh Wu and Ta-Fu Chen and Tsun-Jen Cheng",

year = "2020",

doi = "10.1186/s12989-020-00388-6",

language = "???core.languages.zh_TW???",

volume = "17",

journal = "Particle and Fibre Toxicology",

issn = "1743-8977",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Neuropathology changed by 3- and 6-months low-level PM2.5 inhalation exposure in spontaneously hypertensive rats

AU - Chuang, Hsiao-Chi

AU - Chen, Hsin-Chang

AU - Chai, Pei-Jui

AU - Liao, Ho-Tang

AU - Wu, Chang-Fu

AU - Chen, Chia-Ling

AU - Jhan, Ming-Kai

AU - Hsieh, Hui-I

AU - Wu, Kuen-Yuh

AU - Chen, Ta-Fu

AU - Cheng, Tsun-Jen

PY - 2020

Y1 - 2020

N2 - Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM2.5 in spontaneously hypertensive (SH) rats.

AB - Epidemiological evidence has linked fine particulate matter (PM2.5) to neurodegenerative diseases; however, the toxicological evidence remains unclear. The objective of this study was to investigate the effects of PM2.5 on neuropathophysiology in a hypertensive animal model. We examined behavioral alterations (Morris water maze), lipid peroxidation (malondialdehyde (MDA)), tau and autophagy expressions, neuron death, and caspase-3 levels after 3 and 6 months of whole-body exposure to urban PM2.5 in spontaneously hypertensive (SH) rats.

U2 - 10.1186/s12989-020-00388-6

DO - 10.1186/s12989-020-00388-6

M3 - 文章

VL - 17

JO - Particle and Fibre Toxicology

JF - Particle and Fibre Toxicology

SN - 1743-8977

IS - 1

ER -