Neuropathic Itch

James Meixiong, Xinzhong Dong, Hao Jui Weng

Research output: Contribution to journalReview articlepeer-review

Abstract

Neurologic insults as varied as inflammation, stroke, and fibromyalgia elicit neuropathic pain and itch. Noxious sensation results when aberrantly increased afferent signaling reaches percept-forming cortical neurons and can occur due to increased sensory signaling, decreased inhibitory signaling, or a combination of both processes. To treat these symptoms, detailed knowledge of sensory transmission, from innervated end organ to cortex, is required. Molecular, genetic, and behavioral dissection of itch in animals and patients has improved understanding of the receptors, cells, and circuits involved. In this review, we will discuss neuropathic itch with a focus on the itch-specific circuit.

Original languageEnglish
JournalCells
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 9 2020

Keywords

  • inflammation
  • neuropathy
  • pruritus

ASJC Scopus subject areas

  • Medicine(all)

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