Neuronal variability of Resting State activity in Eating Disorders: increase and decoupling in Ventral Attention Network and relation with clinical symptoms

Angela V. Spalatro, Federico Amianto, Zirui Huang, Federico D'Agata, Mauro Bergui, Giovanni Abbate Daga, Secondo Fassino, Georg Northoff

Research output: Contribution to journalArticle

Abstract

Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.

LanguageEnglish
Pages10-17
Number of pages8
JournalEuropean Psychiatry
Volume55
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

Fingerprint

Appetite Depressants
Bulimia Nervosa
Anorexia Nervosa
Psychometrics
Feeding and Eating Disorders
Biomarkers
Magnetic Resonance Imaging
Oxygen
Therapeutics

Keywords

  • Eating Disorders
  • Inhibitory control
  • Interoceptive awareness
  • Neuronal variability
  • Ventral Attention Network

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Neuronal variability of Resting State activity in Eating Disorders : increase and decoupling in Ventral Attention Network and relation with clinical symptoms. / Spalatro, Angela V.; Amianto, Federico; Huang, Zirui; D'Agata, Federico; Bergui, Mauro; Abbate Daga, Giovanni; Fassino, Secondo; Northoff, Georg.

In: European Psychiatry, Vol. 55, 01.01.2019, p. 10-17.

Research output: Contribution to journalArticle

Spalatro, Angela V. ; Amianto, Federico ; Huang, Zirui ; D'Agata, Federico ; Bergui, Mauro ; Abbate Daga, Giovanni ; Fassino, Secondo ; Northoff, Georg. / Neuronal variability of Resting State activity in Eating Disorders : increase and decoupling in Ventral Attention Network and relation with clinical symptoms. In: European Psychiatry. 2019 ; Vol. 55. pp. 10-17.
@article{56a7e0496587460a8eedc35049a3887b,
title = "Neuronal variability of Resting State activity in Eating Disorders: increase and decoupling in Ventral Attention Network and relation with clinical symptoms",
abstract = "Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.",
keywords = "Eating Disorders, Inhibitory control, Interoceptive awareness, Neuronal variability, Ventral Attention Network",
author = "Spalatro, {Angela V.} and Federico Amianto and Zirui Huang and Federico D'Agata and Mauro Bergui and {Abbate Daga}, Giovanni and Secondo Fassino and Georg Northoff",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.eurpsy.2018.08.005",
language = "English",
volume = "55",
pages = "10--17",
journal = "European Psychiatry",
issn = "0924-9338",
publisher = "Elsevier Masson",

}

TY - JOUR

T1 - Neuronal variability of Resting State activity in Eating Disorders

T2 - European Psychiatry

AU - Spalatro, Angela V.

AU - Amianto, Federico

AU - Huang, Zirui

AU - D'Agata, Federico

AU - Bergui, Mauro

AU - Abbate Daga, Giovanni

AU - Fassino, Secondo

AU - Northoff, Georg

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.

AB - Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.

KW - Eating Disorders

KW - Inhibitory control

KW - Interoceptive awareness

KW - Neuronal variability

KW - Ventral Attention Network

UR - http://www.scopus.com/inward/record.url?scp=85055546625&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055546625&partnerID=8YFLogxK

U2 - 10.1016/j.eurpsy.2018.08.005

DO - 10.1016/j.eurpsy.2018.08.005

M3 - Article

VL - 55

SP - 10

EP - 17

JO - European Psychiatry

JF - European Psychiatry

SN - 0924-9338

ER -