Neuromodulation in Beta-Band Power Between Movement Execution and Inhibition in the Human Hippocampus

Roberto Martin del Campo-Vera, Austin M. Tang, Angad S. Gogia, Kuang Hsuan Chen, Rinu Sebastian, Zachary D. Gilbert, George Nune, Charles Y. Liu, Spencer Kellis, Brian Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: The hippocampus is thought to be involved in movement, but its precise role in movement execution and inhibition has not been well studied. Previous work with direct neural recordings has found beta-band (13–30 Hz) modulation in both movement execution and inhibition throughout the motor system, but the role of beta-band modulation in the hippocampus during movement inhibition is not well understood. Here, we perform a Go/No-Go reaching task in ten patients with medically refractory epilepsy to study human hippocampal beta-power changes during movement. Materials and Methods: Ten epilepsy patients (5 female; ages 21–46) were implanted with intracranial depth electrodes for seizure monitoring and localization. Local field potentials were sampled at 2000 Hz during a Go/No-Go movement task. Comparison of beta-band power between Go and No-Go conditions was conducted using Wilcoxon signed-rank hypothesis testing for each patient. Sub-analyses were conducted to assess differences in the anterior vs. posterior contacts, ipsilateral vs. contralateral contacts, and male vs. female beta power values. Results: Eight out of ten patients showed significant beta-power decreases during the Go movement response (p < 0.05) compared to baseline. Eight out of ten patients also showed significant beta power increases in the No-Go condition, occurring in the absence of movement. No significant differences were noted between ipsilateral vs. contralateral contacts, nor in anterior vs. posterior hippocampal contacts. Female participants had a higher task success rate than males and had significantly greater beta-power increases in the No-Go condition (p < 0.001). Conclusion: These findings indicate that increases in hippocampal beta power are associated with movement inhibition. To the best of our knowledge, this study is the first to report this phenomenon in the human hippocampus. The beta band may represent a state-change signal involved in motor processing. Future focus on the beta band in understanding human motor and impulse control will be vital.

Original languageEnglish
JournalNeuromodulation
DOIs
Publication statusAccepted/In press - 2021
Externally publishedYes

Keywords

  • Beta-band
  • hippocampus
  • human
  • modulation
  • motor inhibition
  • power spectrum
  • stereo EEG

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

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