Neuroinflammation in animal models of traumatic brain injury

Chong Chi Chiu, Yi En Liao, Ling Yu Yang, Jing Ya Wang, David Tweedie, Hanuma K. Karnati, Nigel H Greig, Jia-Yi Wang

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Traumatic brain injury (TBI) is a leading cause of mortality and morbidity worldwide. Neuroinflammation is prominent in the short and long-term consequences of neuronal injuries that occur after TBI. Neuroinflammation involves the activation of glia, including microglia and astrocytes, to release inflammatory mediators within the brain, and the subsequent recruitment of peripheral immune cells. Various animal models of TBI have been developed that have proved valuable to elucidate the pathophysiology of the disorder and to assess the safety and efficacy of novel therapies prior to clinical trials. These models provide an excellent platform to delineate key injury mechanisms that associate with types of injury (concussion, contusion, and penetration injuries) that occur clinically for the investigation of mild, moderate, and severe forms of TBI. Additionally, TBI modeling in genetically engineered mice, in particular, has aided the identification of key molecules and pathways for putative injury mechanisms, as targets for development of novel therapies for human TBI. This Review details the evidence showing that neuroinflammation, characterized by the activation of microglia and astrocytes and elevated production of inflammatory mediators, is a critical process occurring in various TBI animal models, provides a broad overview of commonly used animal models of TBI, and overviews representative techniques to quantify markers of the brain inflammatory process. A better understanding of neuroinflammation could open therapeutic avenues for abrogation of secondary cell death and behavioral symptoms that may mediate the progression of TBI.

Original languageEnglish
Pages (from-to)38-49
Number of pages12
JournalJournal of Neuroscience Methods
Volume272
DOIs
Publication statusPublished - Oct 15 2016

Fingerprint

Animal Models
Wounds and Injuries
Microglia
Astrocytes
Traumatic Brain Injury
Behavioral Symptoms
Contusions
Brain
Neuroglia
Cell Death
Therapeutics
Clinical Trials
Morbidity
Safety
Mortality

Keywords

  • Astrocytes
  • Controlled cortical impact
  • Glia cells
  • Lateralfluid percussion
  • Measurements evaluating neuroinflammation
  • Microglia
  • Neuroinflammation
  • Traumatic brain injury (TBI)
  • Weight-drop impact

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Chiu, C. C., Liao, Y. E., Yang, L. Y., Wang, J. Y., Tweedie, D., Karnati, H. K., ... Wang, J-Y. (2016). Neuroinflammation in animal models of traumatic brain injury. Journal of Neuroscience Methods, 272, 38-49. https://doi.org/10.1016/j.jneumeth.2016.06.018

Neuroinflammation in animal models of traumatic brain injury. / Chiu, Chong Chi; Liao, Yi En; Yang, Ling Yu; Wang, Jing Ya; Tweedie, David; Karnati, Hanuma K.; Greig, Nigel H; Wang, Jia-Yi.

In: Journal of Neuroscience Methods, Vol. 272, 15.10.2016, p. 38-49.

Research output: Contribution to journalArticle

Chiu, CC, Liao, YE, Yang, LY, Wang, JY, Tweedie, D, Karnati, HK, Greig, NH & Wang, J-Y 2016, 'Neuroinflammation in animal models of traumatic brain injury', Journal of Neuroscience Methods, vol. 272, pp. 38-49. https://doi.org/10.1016/j.jneumeth.2016.06.018
Chiu CC, Liao YE, Yang LY, Wang JY, Tweedie D, Karnati HK et al. Neuroinflammation in animal models of traumatic brain injury. Journal of Neuroscience Methods. 2016 Oct 15;272:38-49. https://doi.org/10.1016/j.jneumeth.2016.06.018
Chiu, Chong Chi ; Liao, Yi En ; Yang, Ling Yu ; Wang, Jing Ya ; Tweedie, David ; Karnati, Hanuma K. ; Greig, Nigel H ; Wang, Jia-Yi. / Neuroinflammation in animal models of traumatic brain injury. In: Journal of Neuroscience Methods. 2016 ; Vol. 272. pp. 38-49.
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