Neuroblastoma with expression of erythropoietin resulting in erythrocytosis

Lin Y. Wang, Lee Yung Shih, Shu Huey Chen, Hsi C. Liu, I. J. Chai, Der Cherng Liang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report the detection of erythropoietin mRNA in the tumor from a patient with neuroblastoma and erythrocytosis. A 2-year-old girl with neuroblastoma presented with hemoglobin 21.3 g/dL, red blood cells 8.03 x 1012/L, and hematocrit 0.641. The serum erythropoietin level was 26.54 mU/mL. The hemoglobin, hematocrit, and serum erythropoietin level were within normal ranges 3 months after surgical excision of the tumor. RT-PCR analysis showed that erythropoietin mRNA expression in the tumor tissue was as high as that of normal renal tissue. These results conclusively demonstrated that the tumor was the site of the ectopic erythropoietin production.

Original languageEnglish
Pages (from-to)649-650
Number of pages2
JournalJournal of Pediatric Hematology/Oncology
Volume25
Issue number8
DOIs
Publication statusPublished - Aug 2003
Externally publishedYes

Keywords

  • Erythrocytosis
  • Erythropoietin
  • Neuroblastoma
  • RT-PCR

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

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