Neural substrates of respiratory sensory gating: A human fMRI study

Pei Ying S. Chan, Chia Hsiung Cheng, Yu Ting Wu, Changwei W. Wu, Ai Ling Hsu, Chia Yih Liu, Ho Ling Liu, Paul W. Davenport

Research output: Contribution to journalArticlepeer-review

Abstract

The involvement of neural substrates in respiratory sensory gating remained unclear. This study aimed to investigate cortical and subcortical activations associated with respiratory sensory gating by using functional magnetic resonance imaging. First, we hypothesized that paired occlusions would induce neural activation in cortical and subcortical areas, including the thalamus and sensorimotor cortices. Secondly, we hypothesized that, in terms of parameter estimates in the general linear model, the activation effect size β ratios (βpairedsingle) would be less than 2 due to central neural gating mechanism. Forty-six healthy participants were included in the study. Our analyses showed that the βpaired/βsingle ratios for the supramarginal gyrus, basal ganglia, thalamus, and middle frontal gyrus were less than 2. In conclusion, our results demonstrated a non-linear relationship regarding brain neural activations in response to paired versus single occlusions, suggesting that respiratory sensory information is gated at the subcortical and cortical levels.

Original languageEnglish
Article number108277
JournalBiological Psychology
Volume169
DOIs
Publication statusPublished - Mar 2022

Keywords

  • Cortical and subcortical substrates
  • Human fMRI
  • Paired inspiratory occlusions
  • Respiratory sensation
  • Respiratory sensory gating

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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