Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study

Nir Lipsman; Takashi Nakao; Noriaki Kanayama; Joachim Kurt Krauss; Adam K. Anderson; Peter Giacobbe; Clement Hamani; William Duncan Hutchison; Jonathan O. Dostrovsky; Thilo Womelsdorf; Andrés M. Lozano; Georg Franz Josef Northoff

doi:10.1016/j.cortex.2014.09.008

Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study

Nir Lipsman, Takashi Nakao, Noriaki Kanayama, Joachim Kurt Krauss, Adam K. Anderson, Peter Giacobbe, Clement Hamani, William Duncan Hutchison, Jonathan O. Dostrovsky, Thilo Womelsdorf, Andrés M. Lozano, Georg Franz Josef Northoff

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

High activity of the default mode network (DMN) has been proposed to be central in processing self-relevant events. Thus far, this hypothesis of DMN function has not been tested directly using neurophysiological techniques. To test for the link between frontal midline DMN activity and self-relevant processing we measured neuronal activity (single-neurons' firing rates) in human subcallosal cingulate cortex (SCC) in the course of Deep Brain Stimulation surgery. We find that firing rates in SCC did not change during the presentation of specifically self-relevant stimuli when compared to the preceding pre-stimulus resting state level. In contrast, we observed significant changes in firing rates during other names in SCC. Such rest-self overlap seems to be specific for SCC since increase in firing rates in response to self-relevant stimuli were observed in another region, the subthalamic nucleus, in a group of Parkinson patients receiving deep brain stimulation surgery. These results suggest specific relationship between resting state and self-related activity, rest-self overlap, in specifically SCC as core region of the default-mode network. © 2014 Elsevier Ltd.

Original language	English
Pages (from-to)	139-144
Number of pages	6
Journal	Cerebral Cortex
Volume	60
DOIs	https://doi.org/10.1016/j.cortex.2014.09.008
Publication status	Published - 2014

Keywords

Deep brain stimulation
Default-mode network
Resting state
Self-relevance
Single-unit recording
Subcallosal cingulate cortex
action potential
Article
brain depth recording
brain depth stimulation
cell activity
cingulate gyrus
clinical article
comparative study
default mode network
human
nerve stimulation
subcallosal cingulate cortex
subthalamic nucleus
Depressive Disorder, Major
electroencephalography
nerve cell
Parkinson disease
pathophysiology
physiology
rest
Deep Brain Stimulation
Electroencephalography
Gyrus Cinguli
Humans
Neurons
Parkinson Disease
Rest

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Lipsman, N., Nakao, T., Kanayama, N., Krauss, J. K., Anderson, A. K., Giacobbe, P., Hamani, C., Hutchison, W. D., Dostrovsky, J. O., Womelsdorf, T., Lozano, A. M., & Northoff, G. F. J. (2014). Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study. Cerebral Cortex, 60, 139-144. https://doi.org/10.1016/j.cortex.2014.09.008

Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study. / Lipsman, Nir; Nakao, Takashi; Kanayama, Noriaki; Krauss, Joachim Kurt; Anderson, Adam K.; Giacobbe, Peter; Hamani, Clement; Hutchison, William Duncan; Dostrovsky, Jonathan O.; Womelsdorf, Thilo; Lozano, Andrés M.; Northoff, Georg Franz Josef.

In: Cerebral Cortex, Vol. 60, 2014, p. 139-144.

Research output: Contribution to journal › Article › peer-review

Lipsman, N, Nakao, T, Kanayama, N, Krauss, JK, Anderson, AK, Giacobbe, P, Hamani, C, Hutchison, WD, Dostrovsky, JO, Womelsdorf, T, Lozano, AM & Northoff, GFJ 2014, 'Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study', Cerebral Cortex, vol. 60, pp. 139-144. https://doi.org/10.1016/j.cortex.2014.09.008

Lipsman, Nir ; Nakao, Takashi ; Kanayama, Noriaki ; Krauss, Joachim Kurt ; Anderson, Adam K. ; Giacobbe, Peter ; Hamani, Clement ; Hutchison, William Duncan ; Dostrovsky, Jonathan O. ; Womelsdorf, Thilo ; Lozano, Andrés M. ; Northoff, Georg Franz Josef. / Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study. In: Cerebral Cortex. 2014 ; Vol. 60. pp. 139-144.

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title = "Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study",

abstract = "High activity of the default mode network (DMN) has been proposed to be central in processing self-relevant events. Thus far, this hypothesis of DMN function has not been tested directly using neurophysiological techniques. To test for the link between frontal midline DMN activity and self-relevant processing we measured neuronal activity (single-neurons' firing rates) in human subcallosal cingulate cortex (SCC) in the course of Deep Brain Stimulation surgery. We find that firing rates in SCC did not change during the presentation of specifically self-relevant stimuli when compared to the preceding pre-stimulus resting state level. In contrast, we observed significant changes in firing rates during other names in SCC. Such rest-self overlap seems to be specific for SCC since increase in firing rates in response to self-relevant stimuli were observed in another region, the subthalamic nucleus, in a group of Parkinson patients receiving deep brain stimulation surgery. These results suggest specific relationship between resting state and self-related activity, rest-self overlap, in specifically SCC as core region of the default-mode network. {\textcopyright} 2014 Elsevier Ltd.",

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author = "Nir Lipsman and Takashi Nakao and Noriaki Kanayama and Krauss, {Joachim Kurt} and Anderson, {Adam K.} and Peter Giacobbe and Clement Hamani and Hutchison, {William Duncan} and Dostrovsky, {Jonathan O.} and Thilo Womelsdorf and Lozano, {Andr{\'e}s M.} and Northoff, {Georg Franz Josef}",

note = "Cited By :2 Export Date: 11 May 2016 CODEN: CRTXA Correspondence Address: Northoff, G.; Mind, Brain Imaging and Neuroethics, Canada Research Chair, University of Ottawa, The Michael Smith Chair, ELJB-CIHR, Royal Ottawa Healthcare Group, University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, Room 6435, Canada References: Alcaro, A., Panksepp, J., Witczak, J., Hayes, D.J., Northoff, G., Is subcortical-cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach (2010) Neuroscience & Biobehavioral Reviews, 34 (4), pp. 592-605; Buckner, R.L., Andrews-Hanna, J.R., Schacter, D.L., The brain's default network: anatomy, function, and relevance to disease (2008) Annals of the New York Academy of Sciences, 1124, pp. 1-38; D'Argembeau, A., Collette, F., Van der Linden, M., Laureys, S., Del Fiore, G., Degueldre, C., Self-referential reflective activity and its relationship with rest: a PET study (2005) NeuroImage, 25 (2), pp. 616-624; Davis, K.D., Taylor, K.S., Hutchison, W.D., Dostrovsky, J.O., McAndrews, M.P., Richter, E.O., Human anterior cingulate cortex neurons encode cognitive and emotional demands (2005) The Journal of Neuroscience, 25 (37), pp. 8402-8406; Farb, N.A., Segal, Z.V., Mayberg, H., Bean, J., McKeon, D., Fatima, Z., Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference (2007) Social Cognitive and Affective Neuroscience, 2 (4), pp. 313-322; Grimm, S., Ernst, J., Boesiger, P., Schuepbach, D., Hell, D., Boeker, H., Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures (2009) Human Brain Mapping, 30 (8), pp. 2617-2627; Gusnard, D.A., Akbudak, E., Shulman, G.L., Raichle, M.E., Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (7), pp. 4259-4264; Hutchison, R.M., Womelsdorf, T., Gati, J.S., Leung, L.S., Menon, R.S., Everling, S., Resting-state connectivity identifies distinct functional networks in macaque cingulate cortex (2012) Cerebral Cortex, 22, pp. 1294-1308; K{\"u}hn, A.A., Hariz, M., Silberstein, P., Tisch, S., Kupsch, A., Schneider, G.H., Activation of the subthalamic region during emotional processing in Parkinson's disease (2005) Neurology, 65 (5), pp. 707-713; K{\"u}hn, S., Gallinat, J., Resting-state brain activity in schizophrenia and major depression: a quantitative meta-analysis (2013) Schizophrenia Bulletin, 39 (2), pp. 358-365. , Epub 2011 Nov 10; Lemogne, C., Delaveau, P., Freton, M., Guionnet, S., Fossati, P., Medial prefrontal cortex and the self in major depression (2012) Journal of Affective Disorders, 136 (1-2), pp. e1-e11; Lemogne, C., Mayberg, H., Bergouignan, L., Volle, E., Delaveau, P., Leh{\'e}ricy, S., Self-referential processing and the prefrontal cortex over the course of depression: a pilot study (2010) Journal of Affective Disorders, 124 (1-2), pp. 196-201; Lou, H.C., Joensson, M., Biermann-Ruben, K., Schnitzler, A., {\O}stergaard, L., Kjaer, T.W., Recurrent activity in higher order, modality non-specific brain regions: a Granger causality analysis of autobiographic memory retrieval (2011) PLoS One, 6 (7), p. e22286; Lozano, A.M., Mayberg, H.S., Giacobbe, P., Hamani, C., Craddock, R.C., Kennedy, S.H., Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression (2008) Biological Psychiatry, 64 (6), pp. 461-467; Mantini, D., Gerits, A., Nelissen, K., Durand, J.B., Joly, O., Simone, L., Default mode of brain function in monkeys (2011) The Journal of Neuroscience, 31 (36), pp. 12954-12962; Mayberg, H.S., Lozano, A.M., Voon, V., McNeely, H.E., Seminowicz, D., Hamani, C., Deep brain stimulation for treatment-resistant depression (2005) Neuron, 45 (5), pp. 651-660; van der Meer, L., Costafreda, S., Aleman, A., David, A.S., Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia (2010) Neuroscience & Biobehavioral Reviews, 34 (6), pp. 935-946; Moran, J.M., Macrae, C.N., Heatherton, T.F., Wyland, C.L., Kelley, W.M., Neuroanatomical evidence for distinct cognitive and affective components of self (2006) Journal of Cognitive Neuroscience, 18 (9), pp. 1586-1594; Northoff, G., (2014) Unlocking the brain. Volume I: Coding, , Oxford University Press, Oxford, New York; Northoff, G., (2014) Unlocking the brain. Volume II: Consciousness, , Oxford University Press, Oxford, New York; Northoff, G., Bermpohl, F., Cortical midline structures and the self (2004) Trends in Cognitive Sciences, 8 (3), pp. 102-107; Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., Panksepp, J., Self-referential processing in our brain - a meta-analysis of imaging studies on the self (2006) NeuroImage, 31 (1), pp. 440-457; Northoff, G., Qin, P., Nakao, T., Rest-stimulus interaction in the brain: a review (2010) Trends in Neurosciences, 33 (6), pp. 277-284; Northoff, G., Schneider, F., Rotte, M., Matthiae, C., Tempelmann, C., Wiebking, C., Differential parametric modulation of self-relatedness and emotions in different brain regions (2009) Human Brain Mapping, 30 (2), pp. 369-382; Northoff, G., Wiebking, C., Feinberg, T., Panksepp, J., The 'resting-state hypothesis' of major depressive disorder - a translational subcortical-cortical framework for a system disorder (2011) Neuroscience & Biobehavioral Reviews, 35 (9), pp. 1929-1945; Qin, P., Northoff, G., How is our self related to midline regions and the default-mode network? (2011) NeuroImage, 57 (3), pp. 1221-1233; Raichle, M.E., A brief history of human brain mapping (2009) Trends in Neurosciences, 32 (2), pp. 118-126; Raichle, M.E., Chapter 18: the origins of functional brain imaging in humans (2010) Handbook of Clinical Neurology, 95, pp. 257-268; Raichle, M.E., MacLeod, A.M., Snyder, A.Z., Powers, W.J., Gusnard, D.A., Shulman, G.L., A default mode of brain function (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (2), pp. 676-682; Rilling, J.K., Barks, S.K., Parr, L.A., Preuss, T.M., Faber, T.L., Pagnoni, G., A comparison of resting-state brain activity in humans and chimpanzees (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (43), pp. 17146-17151; Schneider, F., Bermpohl, F., Heinzel, A., Rotte, M., Walter, M., Tempelmann, C., The resting brain and our self: self-relatedness modulates resting state neural activity in cortical midline structures (2008) Neuroscience, 157 (1), pp. 120-131; Vanhaudenhuyse, A., Demertzi, A., Schabus, M., Noirhomme, Q., Bredart, S., Boly, M., Two distinct neuronal networks mediate the awareness of environment and of self (2011) Journal of Cognitive Neuroscience, 23 (3), pp. 570-578; Whitfield-Gabrieli, S., Moran, J.M., Nieto-Casta{\~n}{\'o}n, A., Triantafyllou, C., Saxe, R., Gabrieli, J.D., Associations and dissociations between default and self-reference networks in the human brain (2011) NeuroImage, 55 (1), pp. 225-232; Wichmann, T., Dostrovsky, J.O., Pathological basal ganglia activity in movement disorders (2011) Neuroscience, 198, pp. 232-244; Wiebking, C., Duncan, N.W., Qin, P., Hayes, D.J., Lyttelton, O., Gravel, P., External awareness and GABA - a multimodal imaging study combining fMRI and [18F]flumazenil-PET (2014) Hum Brain Mapp, 35, pp. 173-184. , Epub 2012 Sep 21",

year = "2014",

doi = "10.1016/j.cortex.2014.09.008",

language = "English",

volume = "60",

pages = "139--144",

journal = "Cortex",

issn = "1047-3211",

publisher = "Masson SpA",

}

TY - JOUR

T1 - Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study

AU - Lipsman, Nir

AU - Nakao, Takashi

AU - Kanayama, Noriaki

AU - Krauss, Joachim Kurt

AU - Anderson, Adam K.

AU - Giacobbe, Peter

AU - Hamani, Clement

AU - Hutchison, William Duncan

AU - Dostrovsky, Jonathan O.

AU - Womelsdorf, Thilo

AU - Lozano, Andrés M.

AU - Northoff, Georg Franz Josef

N1 - Cited By :2 Export Date: 11 May 2016 CODEN: CRTXA Correspondence Address: Northoff, G.; Mind, Brain Imaging and Neuroethics, Canada Research Chair, University of Ottawa, The Michael Smith Chair, ELJB-CIHR, Royal Ottawa Healthcare Group, University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, Room 6435, Canada References: Alcaro, A., Panksepp, J., Witczak, J., Hayes, D.J., Northoff, G., Is subcortical-cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach (2010) Neuroscience & Biobehavioral Reviews, 34 (4), pp. 592-605; Buckner, R.L., Andrews-Hanna, J.R., Schacter, D.L., The brain's default network: anatomy, function, and relevance to disease (2008) Annals of the New York Academy of Sciences, 1124, pp. 1-38; D'Argembeau, A., Collette, F., Van der Linden, M., Laureys, S., Del Fiore, G., Degueldre, C., Self-referential reflective activity and its relationship with rest: a PET study (2005) NeuroImage, 25 (2), pp. 616-624; Davis, K.D., Taylor, K.S., Hutchison, W.D., Dostrovsky, J.O., McAndrews, M.P., Richter, E.O., Human anterior cingulate cortex neurons encode cognitive and emotional demands (2005) The Journal of Neuroscience, 25 (37), pp. 8402-8406; Farb, N.A., Segal, Z.V., Mayberg, H., Bean, J., McKeon, D., Fatima, Z., Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference (2007) Social Cognitive and Affective Neuroscience, 2 (4), pp. 313-322; Grimm, S., Ernst, J., Boesiger, P., Schuepbach, D., Hell, D., Boeker, H., Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures (2009) Human Brain Mapping, 30 (8), pp. 2617-2627; Gusnard, D.A., Akbudak, E., Shulman, G.L., Raichle, M.E., Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (7), pp. 4259-4264; Hutchison, R.M., Womelsdorf, T., Gati, J.S., Leung, L.S., Menon, R.S., Everling, S., Resting-state connectivity identifies distinct functional networks in macaque cingulate cortex (2012) Cerebral Cortex, 22, pp. 1294-1308; Kühn, A.A., Hariz, M., Silberstein, P., Tisch, S., Kupsch, A., Schneider, G.H., Activation of the subthalamic region during emotional processing in Parkinson's disease (2005) Neurology, 65 (5), pp. 707-713; Kühn, S., Gallinat, J., Resting-state brain activity in schizophrenia and major depression: a quantitative meta-analysis (2013) Schizophrenia Bulletin, 39 (2), pp. 358-365. , Epub 2011 Nov 10; Lemogne, C., Delaveau, P., Freton, M., Guionnet, S., Fossati, P., Medial prefrontal cortex and the self in major depression (2012) Journal of Affective Disorders, 136 (1-2), pp. e1-e11; Lemogne, C., Mayberg, H., Bergouignan, L., Volle, E., Delaveau, P., Lehéricy, S., Self-referential processing and the prefrontal cortex over the course of depression: a pilot study (2010) Journal of Affective Disorders, 124 (1-2), pp. 196-201; Lou, H.C., Joensson, M., Biermann-Ruben, K., Schnitzler, A., Østergaard, L., Kjaer, T.W., Recurrent activity in higher order, modality non-specific brain regions: a Granger causality analysis of autobiographic memory retrieval (2011) PLoS One, 6 (7), p. e22286; Lozano, A.M., Mayberg, H.S., Giacobbe, P., Hamani, C., Craddock, R.C., Kennedy, S.H., Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression (2008) Biological Psychiatry, 64 (6), pp. 461-467; Mantini, D., Gerits, A., Nelissen, K., Durand, J.B., Joly, O., Simone, L., Default mode of brain function in monkeys (2011) The Journal of Neuroscience, 31 (36), pp. 12954-12962; Mayberg, H.S., Lozano, A.M., Voon, V., McNeely, H.E., Seminowicz, D., Hamani, C., Deep brain stimulation for treatment-resistant depression (2005) Neuron, 45 (5), pp. 651-660; van der Meer, L., Costafreda, S., Aleman, A., David, A.S., Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia (2010) Neuroscience & Biobehavioral Reviews, 34 (6), pp. 935-946; Moran, J.M., Macrae, C.N., Heatherton, T.F., Wyland, C.L., Kelley, W.M., Neuroanatomical evidence for distinct cognitive and affective components of self (2006) Journal of Cognitive Neuroscience, 18 (9), pp. 1586-1594; Northoff, G., (2014) Unlocking the brain. Volume I: Coding, , Oxford University Press, Oxford, New York; Northoff, G., (2014) Unlocking the brain. Volume II: Consciousness, , Oxford University Press, Oxford, New York; Northoff, G., Bermpohl, F., Cortical midline structures and the self (2004) Trends in Cognitive Sciences, 8 (3), pp. 102-107; Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., Panksepp, J., Self-referential processing in our brain - a meta-analysis of imaging studies on the self (2006) NeuroImage, 31 (1), pp. 440-457; Northoff, G., Qin, P., Nakao, T., Rest-stimulus interaction in the brain: a review (2010) Trends in Neurosciences, 33 (6), pp. 277-284; Northoff, G., Schneider, F., Rotte, M., Matthiae, C., Tempelmann, C., Wiebking, C., Differential parametric modulation of self-relatedness and emotions in different brain regions (2009) Human Brain Mapping, 30 (2), pp. 369-382; Northoff, G., Wiebking, C., Feinberg, T., Panksepp, J., The 'resting-state hypothesis' of major depressive disorder - a translational subcortical-cortical framework for a system disorder (2011) Neuroscience & Biobehavioral Reviews, 35 (9), pp. 1929-1945; Qin, P., Northoff, G., How is our self related to midline regions and the default-mode network? (2011) NeuroImage, 57 (3), pp. 1221-1233; Raichle, M.E., A brief history of human brain mapping (2009) Trends in Neurosciences, 32 (2), pp. 118-126; Raichle, M.E., Chapter 18: the origins of functional brain imaging in humans (2010) Handbook of Clinical Neurology, 95, pp. 257-268; Raichle, M.E., MacLeod, A.M., Snyder, A.Z., Powers, W.J., Gusnard, D.A., Shulman, G.L., A default mode of brain function (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (2), pp. 676-682; Rilling, J.K., Barks, S.K., Parr, L.A., Preuss, T.M., Faber, T.L., Pagnoni, G., A comparison of resting-state brain activity in humans and chimpanzees (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (43), pp. 17146-17151; Schneider, F., Bermpohl, F., Heinzel, A., Rotte, M., Walter, M., Tempelmann, C., The resting brain and our self: self-relatedness modulates resting state neural activity in cortical midline structures (2008) Neuroscience, 157 (1), pp. 120-131; Vanhaudenhuyse, A., Demertzi, A., Schabus, M., Noirhomme, Q., Bredart, S., Boly, M., Two distinct neuronal networks mediate the awareness of environment and of self (2011) Journal of Cognitive Neuroscience, 23 (3), pp. 570-578; Whitfield-Gabrieli, S., Moran, J.M., Nieto-Castañón, A., Triantafyllou, C., Saxe, R., Gabrieli, J.D., Associations and dissociations between default and self-reference networks in the human brain (2011) NeuroImage, 55 (1), pp. 225-232; Wichmann, T., Dostrovsky, J.O., Pathological basal ganglia activity in movement disorders (2011) Neuroscience, 198, pp. 232-244; Wiebking, C., Duncan, N.W., Qin, P., Hayes, D.J., Lyttelton, O., Gravel, P., External awareness and GABA - a multimodal imaging study combining fMRI and [18F]flumazenil-PET (2014) Hum Brain Mapp, 35, pp. 173-184. , Epub 2012 Sep 21

PY - 2014

Y1 - 2014

N2 - High activity of the default mode network (DMN) has been proposed to be central in processing self-relevant events. Thus far, this hypothesis of DMN function has not been tested directly using neurophysiological techniques. To test for the link between frontal midline DMN activity and self-relevant processing we measured neuronal activity (single-neurons' firing rates) in human subcallosal cingulate cortex (SCC) in the course of Deep Brain Stimulation surgery. We find that firing rates in SCC did not change during the presentation of specifically self-relevant stimuli when compared to the preceding pre-stimulus resting state level. In contrast, we observed significant changes in firing rates during other names in SCC. Such rest-self overlap seems to be specific for SCC since increase in firing rates in response to self-relevant stimuli were observed in another region, the subthalamic nucleus, in a group of Parkinson patients receiving deep brain stimulation surgery. These results suggest specific relationship between resting state and self-related activity, rest-self overlap, in specifically SCC as core region of the default-mode network. © 2014 Elsevier Ltd.

AB - High activity of the default mode network (DMN) has been proposed to be central in processing self-relevant events. Thus far, this hypothesis of DMN function has not been tested directly using neurophysiological techniques. To test for the link between frontal midline DMN activity and self-relevant processing we measured neuronal activity (single-neurons' firing rates) in human subcallosal cingulate cortex (SCC) in the course of Deep Brain Stimulation surgery. We find that firing rates in SCC did not change during the presentation of specifically self-relevant stimuli when compared to the preceding pre-stimulus resting state level. In contrast, we observed significant changes in firing rates during other names in SCC. Such rest-self overlap seems to be specific for SCC since increase in firing rates in response to self-relevant stimuli were observed in another region, the subthalamic nucleus, in a group of Parkinson patients receiving deep brain stimulation surgery. These results suggest specific relationship between resting state and self-related activity, rest-self overlap, in specifically SCC as core region of the default-mode network. © 2014 Elsevier Ltd.

KW - Deep brain stimulation

KW - Default-mode network

KW - Resting state

KW - Self-relevance

KW - Single-unit recording

KW - Subcallosal cingulate cortex

KW - action potential

KW - Article

KW - brain depth recording

KW - brain depth stimulation

KW - cell activity

KW - cingulate gyrus

KW - clinical article

KW - comparative study

KW - default mode network

KW - human

KW - nerve stimulation

KW - subcallosal cingulate cortex

KW - subthalamic nucleus

KW - Depressive Disorder, Major

KW - electroencephalography

KW - nerve cell

KW - Parkinson disease

KW - pathophysiology

KW - physiology

KW - rest

KW - Deep Brain Stimulation

KW - Electroencephalography

KW - Gyrus Cinguli

KW - Humans

KW - Neurons

KW - Parkinson Disease

KW - Rest

U2 - 10.1016/j.cortex.2014.09.008

DO - 10.1016/j.cortex.2014.09.008

M3 - Article

C2 - 25438747

VL - 60

SP - 139

EP - 144

JO - Cortex

JF - Cortex

SN - 1047-3211

ER -