Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study

Nir Lipsman, Takashi Nakao, Noriaki Kanayama, Joachim Kurt Krauss, Adam K. Anderson, Peter Giacobbe, Clement Hamani, William Duncan Hutchison, Jonathan O. Dostrovsky, Thilo Womelsdorf, Andrés M. Lozano, Georg Franz Josef Northoff

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

High activity of the default mode network (DMN) has been proposed to be central in processing self-relevant events. Thus far, this hypothesis of DMN function has not been tested directly using neurophysiological techniques. To test for the link between frontal midline DMN activity and self-relevant processing we measured neuronal activity (single-neurons' firing rates) in human subcallosal cingulate cortex (SCC) in the course of Deep Brain Stimulation surgery. We find that firing rates in SCC did not change during the presentation of specifically self-relevant stimuli when compared to the preceding pre-stimulus resting state level. In contrast, we observed significant changes in firing rates during other names in SCC. Such rest-self overlap seems to be specific for SCC since increase in firing rates in response to self-relevant stimuli were observed in another region, the subthalamic nucleus, in a group of Parkinson patients receiving deep brain stimulation surgery. These results suggest specific relationship between resting state and self-related activity, rest-self overlap, in specifically SCC as core region of the default-mode network. © 2014 Elsevier Ltd.
Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalCerebral Cortex
Volume60
DOIs
Publication statusPublished - 2014

Keywords

  • Deep brain stimulation
  • Default-mode network
  • Resting state
  • Self-relevance
  • Single-unit recording
  • Subcallosal cingulate cortex
  • action potential
  • Article
  • brain depth recording
  • brain depth stimulation
  • cell activity
  • cingulate gyrus
  • clinical article
  • comparative study
  • default mode network
  • human
  • nerve stimulation
  • subcallosal cingulate cortex
  • subthalamic nucleus
  • Depressive Disorder, Major
  • electroencephalography
  • nerve cell
  • Parkinson disease
  • pathophysiology
  • physiology
  • rest
  • Deep Brain Stimulation
  • Electroencephalography
  • Gyrus Cinguli
  • Humans
  • Neurons
  • Parkinson Disease
  • Rest

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    Lipsman, N., Nakao, T., Kanayama, N., Krauss, J. K., Anderson, A. K., Giacobbe, P., Hamani, C., Hutchison, W. D., Dostrovsky, J. O., Womelsdorf, T., Lozano, A. M., & Northoff, G. F. J. (2014). Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study. Cerebral Cortex, 60, 139-144. https://doi.org/10.1016/j.cortex.2014.09.008