Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 139-144 |
| Number of pages | 6 |
| Journal | Cerebral Cortex |
| Volume | 60 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Deep brain stimulation
- Default-mode network
- Resting state
- Self-relevance
- Single-unit recording
- Subcallosal cingulate cortex
- action potential
- Article
- brain depth recording
- brain depth stimulation
- cell activity
- cingulate gyrus
- clinical article
- comparative study
- default mode network
- human
- nerve stimulation
- subcallosal cingulate cortex
- subthalamic nucleus
- Depressive Disorder, Major
- electroencephalography
- nerve cell
- Parkinson disease
- pathophysiology
- physiology
- rest
- Deep Brain Stimulation
- Electroencephalography
- Gyrus Cinguli
- Humans
- Neurons
- Parkinson Disease
- Rest
Cite this
Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study. / Lipsman, Nir; Nakao, Takashi; Kanayama, Noriaki; Krauss, Joachim Kurt; Anderson, Adam K.; Giacobbe, Peter; Hamani, Clement; Hutchison, William Duncan; Dostrovsky, Jonathan O.; Womelsdorf, Thilo; Lozano, Andrés M.; Northoff, Georg Franz Josef.
In: Cerebral Cortex, Vol. 60, 2014, p. 139-144.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Neural overlap between resting state and self-relevant activity in human subcallosal cingulate cortex - Single unit recording in an intracranial study
AU - Lipsman, Nir
AU - Nakao, Takashi
AU - Kanayama, Noriaki
AU - Krauss, Joachim Kurt
AU - Anderson, Adam K.
AU - Giacobbe, Peter
AU - Hamani, Clement
AU - Hutchison, William Duncan
AU - Dostrovsky, Jonathan O.
AU - Womelsdorf, Thilo
AU - Lozano, Andrés M.
AU - Northoff, Georg Franz Josef
N1 - Cited By :2 Export Date: 11 May 2016 CODEN: CRTXA Correspondence Address: Northoff, G.; Mind, Brain Imaging and Neuroethics, Canada Research Chair, University of Ottawa, The Michael Smith Chair, ELJB-CIHR, Royal Ottawa Healthcare Group, University of Ottawa Institute of Mental Health Research, 1145 Carling Avenue, Room 6435, Canada References: Alcaro, A., Panksepp, J., Witczak, J., Hayes, D.J., Northoff, G., Is subcortical-cortical midline activity in depression mediated by glutamate and GABA? A cross-species translational approach (2010) Neuroscience & Biobehavioral Reviews, 34 (4), pp. 592-605; Buckner, R.L., Andrews-Hanna, J.R., Schacter, D.L., The brain's default network: anatomy, function, and relevance to disease (2008) Annals of the New York Academy of Sciences, 1124, pp. 1-38; D'Argembeau, A., Collette, F., Van der Linden, M., Laureys, S., Del Fiore, G., Degueldre, C., Self-referential reflective activity and its relationship with rest: a PET study (2005) NeuroImage, 25 (2), pp. 616-624; Davis, K.D., Taylor, K.S., Hutchison, W.D., Dostrovsky, J.O., McAndrews, M.P., Richter, E.O., Human anterior cingulate cortex neurons encode cognitive and emotional demands (2005) The Journal of Neuroscience, 25 (37), pp. 8402-8406; Farb, N.A., Segal, Z.V., Mayberg, H., Bean, J., McKeon, D., Fatima, Z., Attending to the present: mindfulness meditation reveals distinct neural modes of self-reference (2007) Social Cognitive and Affective Neuroscience, 2 (4), pp. 313-322; Grimm, S., Ernst, J., Boesiger, P., Schuepbach, D., Hell, D., Boeker, H., Increased self-focus in major depressive disorder is related to neural abnormalities in subcortical-cortical midline structures (2009) Human Brain Mapping, 30 (8), pp. 2617-2627; Gusnard, D.A., Akbudak, E., Shulman, G.L., Raichle, M.E., Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (7), pp. 4259-4264; Hutchison, R.M., Womelsdorf, T., Gati, J.S., Leung, L.S., Menon, R.S., Everling, S., Resting-state connectivity identifies distinct functional networks in macaque cingulate cortex (2012) Cerebral Cortex, 22, pp. 1294-1308; Kühn, A.A., Hariz, M., Silberstein, P., Tisch, S., Kupsch, A., Schneider, G.H., Activation of the subthalamic region during emotional processing in Parkinson's disease (2005) Neurology, 65 (5), pp. 707-713; Kühn, S., Gallinat, J., Resting-state brain activity in schizophrenia and major depression: a quantitative meta-analysis (2013) Schizophrenia Bulletin, 39 (2), pp. 358-365. , Epub 2011 Nov 10; Lemogne, C., Delaveau, P., Freton, M., Guionnet, S., Fossati, P., Medial prefrontal cortex and the self in major depression (2012) Journal of Affective Disorders, 136 (1-2), pp. e1-e11; Lemogne, C., Mayberg, H., Bergouignan, L., Volle, E., Delaveau, P., Lehéricy, S., Self-referential processing and the prefrontal cortex over the course of depression: a pilot study (2010) Journal of Affective Disorders, 124 (1-2), pp. 196-201; Lou, H.C., Joensson, M., Biermann-Ruben, K., Schnitzler, A., Østergaard, L., Kjaer, T.W., Recurrent activity in higher order, modality non-specific brain regions: a Granger causality analysis of autobiographic memory retrieval (2011) PLoS One, 6 (7), p. e22286; Lozano, A.M., Mayberg, H.S., Giacobbe, P., Hamani, C., Craddock, R.C., Kennedy, S.H., Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression (2008) Biological Psychiatry, 64 (6), pp. 461-467; Mantini, D., Gerits, A., Nelissen, K., Durand, J.B., Joly, O., Simone, L., Default mode of brain function in monkeys (2011) The Journal of Neuroscience, 31 (36), pp. 12954-12962; Mayberg, H.S., Lozano, A.M., Voon, V., McNeely, H.E., Seminowicz, D., Hamani, C., Deep brain stimulation for treatment-resistant depression (2005) Neuron, 45 (5), pp. 651-660; van der Meer, L., Costafreda, S., Aleman, A., David, A.S., Self-reflection and the brain: a theoretical review and meta-analysis of neuroimaging studies with implications for schizophrenia (2010) Neuroscience & Biobehavioral Reviews, 34 (6), pp. 935-946; Moran, J.M., Macrae, C.N., Heatherton, T.F., Wyland, C.L., Kelley, W.M., Neuroanatomical evidence for distinct cognitive and affective components of self (2006) Journal of Cognitive Neuroscience, 18 (9), pp. 1586-1594; Northoff, G., (2014) Unlocking the brain. Volume I: Coding, , Oxford University Press, Oxford, New York; Northoff, G., (2014) Unlocking the brain. Volume II: Consciousness, , Oxford University Press, Oxford, New York; Northoff, G., Bermpohl, F., Cortical midline structures and the self (2004) Trends in Cognitive Sciences, 8 (3), pp. 102-107; Northoff, G., Heinzel, A., de Greck, M., Bermpohl, F., Dobrowolny, H., Panksepp, J., Self-referential processing in our brain - a meta-analysis of imaging studies on the self (2006) NeuroImage, 31 (1), pp. 440-457; Northoff, G., Qin, P., Nakao, T., Rest-stimulus interaction in the brain: a review (2010) Trends in Neurosciences, 33 (6), pp. 277-284; Northoff, G., Schneider, F., Rotte, M., Matthiae, C., Tempelmann, C., Wiebking, C., Differential parametric modulation of self-relatedness and emotions in different brain regions (2009) Human Brain Mapping, 30 (2), pp. 369-382; Northoff, G., Wiebking, C., Feinberg, T., Panksepp, J., The 'resting-state hypothesis' of major depressive disorder - a translational subcortical-cortical framework for a system disorder (2011) Neuroscience & Biobehavioral Reviews, 35 (9), pp. 1929-1945; Qin, P., Northoff, G., How is our self related to midline regions and the default-mode network? (2011) NeuroImage, 57 (3), pp. 1221-1233; Raichle, M.E., A brief history of human brain mapping (2009) Trends in Neurosciences, 32 (2), pp. 118-126; Raichle, M.E., Chapter 18: the origins of functional brain imaging in humans (2010) Handbook of Clinical Neurology, 95, pp. 257-268; Raichle, M.E., MacLeod, A.M., Snyder, A.Z., Powers, W.J., Gusnard, D.A., Shulman, G.L., A default mode of brain function (2001) Proceedings of the National Academy of Sciences of the United States of America, 98 (2), pp. 676-682; Rilling, J.K., Barks, S.K., Parr, L.A., Preuss, T.M., Faber, T.L., Pagnoni, G., A comparison of resting-state brain activity in humans and chimpanzees (2007) Proceedings of the National Academy of Sciences of the United States of America, 104 (43), pp. 17146-17151; Schneider, F., Bermpohl, F., Heinzel, A., Rotte, M., Walter, M., Tempelmann, C., The resting brain and our self: self-relatedness modulates resting state neural activity in cortical midline structures (2008) Neuroscience, 157 (1), pp. 120-131; Vanhaudenhuyse, A., Demertzi, A., Schabus, M., Noirhomme, Q., Bredart, S., Boly, M., Two distinct neuronal networks mediate the awareness of environment and of self (2011) Journal of Cognitive Neuroscience, 23 (3), pp. 570-578; Whitfield-Gabrieli, S., Moran, J.M., Nieto-Castañón, A., Triantafyllou, C., Saxe, R., Gabrieli, J.D., Associations and dissociations between default and self-reference networks in the human brain (2011) NeuroImage, 55 (1), pp. 225-232; Wichmann, T., Dostrovsky, J.O., Pathological basal ganglia activity in movement disorders (2011) Neuroscience, 198, pp. 232-244; Wiebking, C., Duncan, N.W., Qin, P., Hayes, D.J., Lyttelton, O., Gravel, P., External awareness and GABA - a multimodal imaging study combining fMRI and [18F]flumazenil-PET (2014) Hum Brain Mapp, 35, pp. 173-184. , Epub 2012 Sep 21
PY - 2014
Y1 - 2014
N2 - High activity of the default mode network (DMN) has been proposed to be central in processing self-relevant events. Thus far, this hypothesis of DMN function has not been tested directly using neurophysiological techniques. To test for the link between frontal midline DMN activity and self-relevant processing we measured neuronal activity (single-neurons' firing rates) in human subcallosal cingulate cortex (SCC) in the course of Deep Brain Stimulation surgery. We find that firing rates in SCC did not change during the presentation of specifically self-relevant stimuli when compared to the preceding pre-stimulus resting state level. In contrast, we observed significant changes in firing rates during other names in SCC. Such rest-self overlap seems to be specific for SCC since increase in firing rates in response to self-relevant stimuli were observed in another region, the subthalamic nucleus, in a group of Parkinson patients receiving deep brain stimulation surgery. These results suggest specific relationship between resting state and self-related activity, rest-self overlap, in specifically SCC as core region of the default-mode network. © 2014 Elsevier Ltd.
AB - High activity of the default mode network (DMN) has been proposed to be central in processing self-relevant events. Thus far, this hypothesis of DMN function has not been tested directly using neurophysiological techniques. To test for the link between frontal midline DMN activity and self-relevant processing we measured neuronal activity (single-neurons' firing rates) in human subcallosal cingulate cortex (SCC) in the course of Deep Brain Stimulation surgery. We find that firing rates in SCC did not change during the presentation of specifically self-relevant stimuli when compared to the preceding pre-stimulus resting state level. In contrast, we observed significant changes in firing rates during other names in SCC. Such rest-self overlap seems to be specific for SCC since increase in firing rates in response to self-relevant stimuli were observed in another region, the subthalamic nucleus, in a group of Parkinson patients receiving deep brain stimulation surgery. These results suggest specific relationship between resting state and self-related activity, rest-self overlap, in specifically SCC as core region of the default-mode network. © 2014 Elsevier Ltd.
KW - Deep brain stimulation
KW - Default-mode network
KW - Resting state
KW - Self-relevance
KW - Single-unit recording
KW - Subcallosal cingulate cortex
KW - action potential
KW - Article
KW - brain depth recording
KW - brain depth stimulation
KW - cell activity
KW - cingulate gyrus
KW - clinical article
KW - comparative study
KW - default mode network
KW - human
KW - nerve stimulation
KW - subcallosal cingulate cortex
KW - subthalamic nucleus
KW - Depressive Disorder, Major
KW - electroencephalography
KW - nerve cell
KW - Parkinson disease
KW - pathophysiology
KW - physiology
KW - rest
KW - Deep Brain Stimulation
KW - Electroencephalography
KW - Gyrus Cinguli
KW - Humans
KW - Neurons
KW - Parkinson Disease
KW - Rest
U2 - 10.1016/j.cortex.2014.09.008
DO - 10.1016/j.cortex.2014.09.008
M3 - Article
C2 - 25438747
VL - 60
SP - 139
EP - 144
JO - Cortex
JF - Cortex
SN - 1047-3211
ER -