Neural mechanisms of impaired micturition reflex in rats with acute partial bladder outlet obstruction

C. T. Chien, H. J. Yu, T. B. Lin, C. F. Chen

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

To determine the contribution of neural elements to micturition, we evaluated, in intact rats, the cystometrogram, pelvic afferent nervous activity, pelvic efferent nervous activity and external urethral sphincter-electromyogram activity in the normal and acute partial bladder outlet obstruction states. In the normal state, in response to saline filling, mechanoreceptor-dependent pelvic afferent nervous activity gradually activated and finally triggered a voiding reflex, including four phases of detrusor contractions. Phase 1 was characterized by an initial rising intravesical pressure, Phase 2 was characterized by a series of high-frequency oscillations in intravesical pressure, Phase 3 contraction was characterized by a rebound intravesical pressure and Phase 4 contraction was characterized by a rapid fall in intravesical pressure. In the acute partial bladder outlet obstruction state, Phase 1 contraction rose and high-frequency oscillations fell in Phase 2. This voiding dysfunction is ascribed to the bursting extraurethral sphincter activity being converted to tonic extraurethral sphincter activity.In summary, the suppressed high-frequency oscillations in Phase 2 of the detrusor muscle contraction could be detrimental to efficient voidings in the acute partial bladder outlet obstructed rat. Copyright (C) 1999 IBRO.

Original languageEnglish
Pages (from-to)221-230
Number of pages10
JournalNeuroscience
Volume96
Issue number1
DOIs
Publication statusPublished - Jan 2000
Externally publishedYes

Fingerprint

Urinary Bladder Neck Obstruction
Urination
Reflex
Pressure
Mechanoreceptors
Electromyography
Urethra
Muscle Contraction
Urinary Bladder

Keywords

  • Bladder outlet obstruction
  • Cholinergic
  • High-frequency oscillation
  • Pelvic nerve
  • Purinergic

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Neural mechanisms of impaired micturition reflex in rats with acute partial bladder outlet obstruction. / Chien, C. T.; Yu, H. J.; Lin, T. B.; Chen, C. F.

In: Neuroscience, Vol. 96, No. 1, 01.2000, p. 221-230.

Research output: Contribution to journalArticle

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