Neural-crest tumor presenting with chronic diarrhea: A report of three cases

Kuo Ting Tang, Hung Chang Lee, Der Cherng Liang, Shu Huey Chen, Hsi Che Liu, Jin Cherng Sheu

Research output: Contribution to journalArticle

Abstract

The association of chronic diarrhea with neural-crest tumors is uncommon. In the past 12 years, we encountered three cases of neural-crest tumors presenting initially as chronic diarrhea. The incidence of chronic diarrhea in patients with neural-crest tumors at our hospital during this period was 3.8%. These patients (two girls and one boy aged between 15 to 28 mo) presented with a 3-week to 6-month history of chronic diarrhea of unknown cause. A posterior mediastinal mass or abdominal mass found on sonography and chest roentgenography eventually led to the diagnosis of neural-crest tumor in these patients. Pathology revealed ganglioneuroblastoma in two cases and neuroblastoma in one. All three patients received chemotherapy and underwent surgery. Diarrhea ceased postoperatively in all three patients. Although one of the patients died of septic shock during chemotherapy, the other two remained free of disease at 30 and 22 months of postoperative follow-up, respectively. A high index of suspicion is needed to identify cases of neural-crest tumor from the presenting symptom of chronic diarrhea.

Original languageEnglish
Pages (from-to)864-867
Number of pages4
JournalJournal of the Formosan Medical Association = Taiwan yi zhi
Volume101
Issue number12
Publication statusPublished - Dec 1 2002
Externally publishedYes

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Diarrhea
Ganglioneuroblastoma
Drug Therapy
Septic Shock
Neuroblastoma
Radiography
Neural crest tumor
Ultrasonography
Thorax
Pathology
Incidence

Keywords

  • Chronic diarrhea
  • Neural-crest tumor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Neural-crest tumor presenting with chronic diarrhea : A report of three cases. / Tang, Kuo Ting; Lee, Hung Chang; Liang, Der Cherng; Chen, Shu Huey; Liu, Hsi Che; Sheu, Jin Cherng.

In: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 101, No. 12, 01.12.2002, p. 864-867.

Research output: Contribution to journalArticle

Tang, Kuo Ting ; Lee, Hung Chang ; Liang, Der Cherng ; Chen, Shu Huey ; Liu, Hsi Che ; Sheu, Jin Cherng. / Neural-crest tumor presenting with chronic diarrhea : A report of three cases. In: Journal of the Formosan Medical Association = Taiwan yi zhi. 2002 ; Vol. 101, No. 12. pp. 864-867.
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