Nephrotic Syndrome Associated With a Clonal T-Cell Leukemia of Large Granular Lymphocytes With Cytotoxic Function

Stephen V. Orman, Geraldine P. Schechter, Jacqueline Whang Peng, John Guccion, Clara Chan, Richard S. Schulof, Robert J. Shalhoub

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• A 51-year-old man presented with a T-cell leukemia of large granular lymphocytes and rapidly developed a nephrotic syndrome due to presumptive minimal-change glomerulopathy. The E-rosette+, la+ cells demonstrated cytotoxic activity similar to that of natural killer lymphocytes but lacked other T-subset markers, except that one third of them bore Fc(IgG) receptors. Cytogenetic analysis revealed loss of chromosome 10 and the translocation (1;10)(p11;q11) in all metaphases. Regression of the leukemia after chemotherapy was accompanied by a dramatic resolution of the nephrotic syndrome, suggesting that the activated granular lymphocytes induced the renal lesion. The close association of a clonal T-lymphoproliferative disorder with minimal-change nephrotic syndrome lends further support to current views implicating activated T cells or their products in the pathogenesis of this glomerulopathy.

Original languageEnglish
Pages (from-to)1827-1829
Number of pages3
JournalArchives of Internal Medicine
Issue number9
Publication statusPublished - Jan 1 1986
Externally publishedYes


ASJC Scopus subject areas

  • Internal Medicine

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