Nephrotic Syndrome Associated With a Clonal T-Cell Leukemia of Large Granular Lymphocytes With Cytotoxic Function

Stephen V. Orman, Geraldine P. Schechter, Jacqueline Whang Peng, John Guccion, Clara Chan, Richard S. Schulof, Robert J. Shalhoub

Research output: Contribution to journalArticle

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Abstract

• A 51-year-old man presented with a T-cell leukemia of large granular lymphocytes and rapidly developed a nephrotic syndrome due to presumptive minimal-change glomerulopathy. The E-rosette+, la+ cells demonstrated cytotoxic activity similar to that of natural killer lymphocytes but lacked other T-subset markers, except that one third of them bore Fc(IgG) receptors. Cytogenetic analysis revealed loss of chromosome 10 and the translocation (1;10)(p11;q11) in all metaphases. Regression of the leukemia after chemotherapy was accompanied by a dramatic resolution of the nephrotic syndrome, suggesting that the activated granular lymphocytes induced the renal lesion. The close association of a clonal T-lymphoproliferative disorder with minimal-change nephrotic syndrome lends further support to current views implicating activated T cells or their products in the pathogenesis of this glomerulopathy.

Original languageEnglish
Pages (from-to)1827-1829
Number of pages3
JournalArchives of Internal Medicine
Volume146
Issue number9
DOIs
Publication statusPublished - Jan 1 1986
Externally publishedYes

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Large Granular Lymphocytic Leukemia
Lipoid Nephrosis
Nephrotic Syndrome
Lymphocytes
IgG Receptors
Chromosomes, Human, Pair 10
Lymphoproliferative Disorders
Fc Receptors
Cytogenetic Analysis
Metaphase
Leukemia
T-Lymphocytes
Kidney
Drug Therapy

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Nephrotic Syndrome Associated With a Clonal T-Cell Leukemia of Large Granular Lymphocytes With Cytotoxic Function. / Orman, Stephen V.; Schechter, Geraldine P.; Whang Peng, Jacqueline; Guccion, John; Chan, Clara; Schulof, Richard S.; Shalhoub, Robert J.

In: Archives of Internal Medicine, Vol. 146, No. 9, 01.01.1986, p. 1827-1829.

Research output: Contribution to journalArticle

Orman, Stephen V. ; Schechter, Geraldine P. ; Whang Peng, Jacqueline ; Guccion, John ; Chan, Clara ; Schulof, Richard S. ; Shalhoub, Robert J. / Nephrotic Syndrome Associated With a Clonal T-Cell Leukemia of Large Granular Lymphocytes With Cytotoxic Function. In: Archives of Internal Medicine. 1986 ; Vol. 146, No. 9. pp. 1827-1829.
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AU - Chan, Clara

AU - Schulof, Richard S.

AU - Shalhoub, Robert J.

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