Neonatal nociception elevated baseline blood pressure and attenuated cardiovascular responsiveness to noxious stress in adult rats

Ya Chun Chu, Cheryl C H Yang, Ho Tien Lin, Pin Tarng Chen, Kuang Yi Chang, Shun Chin Yang, Terry B J Kuo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Neonatal nociception has significant long-term effects on sensory perception in adult animals. Although neonatal adverse experience affect future responsiveness to stressors is documented, little is known about the involvement of early nociceptive experiences in the susceptibility to subsequent nociceptive stress exposure during adulthood. The aim of this study is to explore the developmental change in cardiovascular regulating activity in adult rats that had been subjected to neonatal nociceptive insults. To address this question, we treated neonatal rats with an intraplantar injection of saline (control) or carrageenan at postnatal day 1. The carrageenan-treated rats exhibited generalized hypoalgesia at basal state, and localized hyperalgesia after re-nociceptive challenge induced by intraplantar injections of complete Freund's adjuvant (CFA) as adults. Then we recorded baseline cardiovascular variables and 24-h responsiveness to an injection of CFA in the free-moving adult rats with telemetric technique. The carrageenan-treated rats showed significantly higher basal blood pressures (110.3±3.16 vs. control 97.0±4.28mmHg). In control animals, baroreceptor reflex sensitivity (BRS) decreased, sympathetic vasomotor activity increased, and parasympathetic activity was inhibited after CFA injection. Blood pressure elevation was evident (107.0±2.75 vs. pre-injection 97.0±4.28mmHg). Comparatively, the carrageenan-treated rats showed a higher BRS (BrrLF 1.03±0.09 vs. control 0.70±0.06ms/mmHg) and higher parasympathetic activity [0.93±0.17 vs. control 0.32±0.02ln(ms2)] after CFA injection. The change in blood pressure is negligible (111.9±4.05 vs. pre-injection 110.3±3.16mmHg). Our research has shown that neonatal nociception alters future pain sensation, raises basal blood pressure level, and attenuates cardiovascular responsiveness to nociceptive stress in adult rats.

Original languageEnglish
Pages (from-to)421-426
Number of pages6
JournalInternational Journal of Developmental Neuroscience
Volume30
Issue number6
DOIs
Publication statusPublished - Oct 2012
Externally publishedYes

Fingerprint

Nociception
Blood Pressure
Freund's Adjuvant
Carrageenan
Injections
Baroreflex
Hyperalgesia
Hypertension
Pain
Research

Keywords

  • Autonomic system
  • Blood pressure
  • Heart rate variability
  • Neonatal pain
  • Neural development

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience

Cite this

Neonatal nociception elevated baseline blood pressure and attenuated cardiovascular responsiveness to noxious stress in adult rats. / Chu, Ya Chun; Yang, Cheryl C H; Lin, Ho Tien; Chen, Pin Tarng; Chang, Kuang Yi; Yang, Shun Chin; Kuo, Terry B J.

In: International Journal of Developmental Neuroscience, Vol. 30, No. 6, 10.2012, p. 421-426.

Research output: Contribution to journalArticle

Chu, Ya Chun ; Yang, Cheryl C H ; Lin, Ho Tien ; Chen, Pin Tarng ; Chang, Kuang Yi ; Yang, Shun Chin ; Kuo, Terry B J. / Neonatal nociception elevated baseline blood pressure and attenuated cardiovascular responsiveness to noxious stress in adult rats. In: International Journal of Developmental Neuroscience. 2012 ; Vol. 30, No. 6. pp. 421-426.
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