Neonatal capsaicin treatment alters immediate ventilatory responses to inhaled wood smoke in rats

Y. R. Kou, Y. S. Lin, C. Y. Ho, C. Z. Lin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Neonatal capsaicin treatment chronically ablates unmyelinated C fibers, yet also destroys a small amount of myelinated fibers. Inhalation of wood smoke evokes respiratory reflexes resulting from stimulation of both lung C-fiber nerve endings (unmyelinated afferents) and irritant receptors (myelinated afferents). This study investigated the influences of neonatal capsaicin treatment on the immediate ventilatory responses to inhaled wood smoke in adult rats. Inhalation of wood smoke (~6 ml) via a tracheostomy immediately triggered only an augmented inspiration in 16 rats neonatally treated with capsaicin (50 mg/kg, subcutaneous injection). In contrast, inhaled wood smoke evoked a slowing of respiration in 11 neonatal vehicle-treated rats and an augmented inspiration in another five. The inability to exhibit the slowing of respiration and the persistence of the augmented inspiration in capsaicin-treated rats are consistent with our hypothesis that these two reflex responses originate from stimulation of lung vagal C-fiber afferents and irritant receptors, respectively. Since all capsaicin-treated rats responded to smoke with an augmented inspiration, it is further suggested that neonatal capsaicin treatment selectively impairs the reflex functions of C-fiber afferents and well preserves the reflex functions of lung irritant receptors. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)115-123
Number of pages9
JournalRespiration Physiology
Volume116
Issue number2-3
DOIs
Publication statusPublished - Aug 3 1999
Externally publishedYes

Fingerprint

Capsaicin
Smoke
Unmyelinated Nerve Fibers
Reflex
Irritants
Lung
Inhalation
Respiration
Therapeutics
Nerve Endings
Tracheostomy
Subcutaneous Injections

Keywords

  • Control of breathing, pulmonary afferents
  • Irritants, wood smoke, pulmonary afferents
  • Mammals, rat
  • Pulmonary afferents, C-fibers, irritant fibers, wood smoke
  • Upper airways, irritant receptors

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Neonatal capsaicin treatment alters immediate ventilatory responses to inhaled wood smoke in rats. / Kou, Y. R.; Lin, Y. S.; Ho, C. Y.; Lin, C. Z.

In: Respiration Physiology, Vol. 116, No. 2-3, 03.08.1999, p. 115-123.

Research output: Contribution to journalArticle

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